Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity

Gi Hoon Son, Dongho Geum, Sooyoung Chung, Joo Kim Eun, Ji Hoon Jo, Chang Mee Kim, Ho Lee Kun, Hyun Kim, Sukwoo Choi, Taek Kim Hyun, Chang Joong Lee, Kyungjin Kim

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Stress in adulthood can have a profound effect on physiology and behavior, but the extent to which prolonged maternal stress affects the brain function of offspring when they are adult remains primarily unknown. In the present work, chronic immobilization stress to pregnant mice affected fetal growth and development. When pups born from stressed mice were reared to adulthood in an environment identical to that of nonstressed controls, several physiological parameters were essentially unaltered. However, spatial learning and memory was significantly impaired in the maternally stressed offspring in adulthood. Furthermore, electrophysiological examination revealed a significant reduction in NMDA receptor-mediated long-term potentiation in the CA1 area of hippocampal slices. Subsequent biochemical analysis demonstrated a substantial decrease in NR1 and NR2B subunits of the NMDA receptor in synapses of the hippocampus, and the interaction between these two subunits appeared to be reduced. These results suggest that prolonged maternal stress leads to long-lasting malfunction of the hippocampus, which extends to and is manifested in adulthood.

Original languageEnglish
Pages (from-to)3309-3318
Number of pages10
JournalJournal of Neuroscience
Volume26
Issue number12
DOIs
Publication statusPublished - 2006 Mar 22

Fingerprint

Neuronal Plasticity
Fetal Development
N-Methyl-D-Aspartate Receptors
Hippocampus
Mothers
Learning
Long-Term Potentiation
Growth and Development
Immobilization
Synapses
Brain
NR2B NMDA receptor
Spatial Memory
Spatial Learning
NR1 NMDA receptor

Keywords

  • Hippocampus
  • Learning and memory
  • Long-term potentiation
  • LTP
  • Maternal stress
  • NMDA receptor
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity. / Son, Gi Hoon; Geum, Dongho; Chung, Sooyoung; Eun, Joo Kim; Jo, Ji Hoon; Kim, Chang Mee; Kun, Ho Lee; Kim, Hyun; Choi, Sukwoo; Hyun, Taek Kim; Lee, Chang Joong; Kim, Kyungjin.

In: Journal of Neuroscience, Vol. 26, No. 12, 22.03.2006, p. 3309-3318.

Research output: Contribution to journalArticle

Son, Gi Hoon ; Geum, Dongho ; Chung, Sooyoung ; Eun, Joo Kim ; Jo, Ji Hoon ; Kim, Chang Mee ; Kun, Ho Lee ; Kim, Hyun ; Choi, Sukwoo ; Hyun, Taek Kim ; Lee, Chang Joong ; Kim, Kyungjin. / Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity. In: Journal of Neuroscience. 2006 ; Vol. 26, No. 12. pp. 3309-3318.
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