Mathematical and computational modeling of drug release from an ocular iontophoretic drug delivery device

Jahed Naghipoor, Negin Jafary, Timon Rabczuk

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The advancement of computational technology has helped the modeling of controlled drug delivery into the biological tissues. One example is the modeling of the drug release into the human eye. Due to natural protective barriers of the eye, ocular drug delivery is considered as a major challenge in the development of treatments for diseases affecting different segments of the eye. In this work, the drug release from a current-mediated drug delivery device into the human eye is mathematically modeled and numerically simulated. The heat conduction, the flow of the aqueous humor in the anterior and posterior cavities are considered in the modeling. The heat distribution in different segments of the eye in the standing and supine positions is considered to study the thermal safety of the device. The effect of the voltage strength on the heat elevation of the eye segments is investigated. Numerical experiments highlight that ocular iontophoresis drug delivery system does not produce significant thermal damage and it is thermally safe for the eye. The mechanism of the drug release from the drug reservoir into different segments of the human eye is also studied. The observations show that the drug distribution in the standing position is asymmetric while the drug distribution in the supine position is symmetric.

Original languageEnglish
Pages (from-to)1035-1049
Number of pages15
JournalInternational Journal of Heat and Mass Transfer
Volume123
DOIs
Publication statusPublished - 2018 Aug 1
Externally publishedYes

Keywords

  • Electric field
  • Fluid flow
  • Iontophoretic ocular drug delivery
  • Numerical simulation
  • Temperature

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Mechanical Engineering
  • Fluid Flow and Transfer Processes

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