Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer

Dong Kee Yi, In Cheol Sun, Ju Hee Ryu, Heebeom Koo, Chul Wan Park, In Chan Youn, Kuiwon Choi, Ick Chan Kwon, Kwang Meyung Kim, Cheol Hee Ahn

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy.

Original languageEnglish
Pages (from-to)2173-2177
Number of pages5
JournalBioconjugate Chemistry
Volume21
Issue number12
DOIs
Publication statusPublished - 2010 Dec 15
Externally publishedYes

Fingerprint

Nanotubes
Metalloproteases
Matrix Metalloproteinases
Nanorods
Gold
Neoplasms
Therapeutics
Imaging techniques
Lasers
Hot Temperature

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Organic Chemistry
  • Pharmaceutical Science
  • Biomedical Engineering
  • Pharmacology

Cite this

Yi, D. K., Sun, I. C., Ryu, J. H., Koo, H., Park, C. W., Youn, I. C., ... Ahn, C. H. (2010). Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer. Bioconjugate Chemistry, 21(12), 2173-2177. https://doi.org/10.1021/bc100308p

Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer. / Yi, Dong Kee; Sun, In Cheol; Ryu, Ju Hee; Koo, Heebeom; Park, Chul Wan; Youn, In Chan; Choi, Kuiwon; Kwon, Ick Chan; Kim, Kwang Meyung; Ahn, Cheol Hee.

In: Bioconjugate Chemistry, Vol. 21, No. 12, 15.12.2010, p. 2173-2177.

Research output: Contribution to journalArticle

Yi, DK, Sun, IC, Ryu, JH, Koo, H, Park, CW, Youn, IC, Choi, K, Kwon, IC, Kim, KM & Ahn, CH 2010, 'Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer', Bioconjugate Chemistry, vol. 21, no. 12, pp. 2173-2177. https://doi.org/10.1021/bc100308p
Yi, Dong Kee ; Sun, In Cheol ; Ryu, Ju Hee ; Koo, Heebeom ; Park, Chul Wan ; Youn, In Chan ; Choi, Kuiwon ; Kwon, Ick Chan ; Kim, Kwang Meyung ; Ahn, Cheol Hee. / Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer. In: Bioconjugate Chemistry. 2010 ; Vol. 21, No. 12. pp. 2173-2177.
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AU - Youn, In Chan

AU - Choi, Kuiwon

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