Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer

Dong Kee Yi, In Cheol Sun, Ju Hee Ryu, Heebeom Koo, Chul Wan Park, In Chan Youn, Kuiwon Choi, Ick Chan Kwon, Kwang Meyung Kim, Cheol Hee Ahn

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76 Citations (Scopus)

Abstract

Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy.

Original languageEnglish
Pages (from-to)2173-2177
Number of pages5
JournalBioconjugate Chemistry
Volume21
Issue number12
DOIs
Publication statusPublished - 2010 Dec 15
Externally publishedYes

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ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Organic Chemistry
  • Pharmaceutical Science
  • Biomedical Engineering
  • Pharmacology

Cite this

Yi, D. K., Sun, I. C., Ryu, J. H., Koo, H., Park, C. W., Youn, I. C., Choi, K., Kwon, I. C., Kim, K. M., & Ahn, C. H. (2010). Matrix metalloproteinase sensitive gold nanorod for simultaneous bioimaging and photothermal therapy of cancer. Bioconjugate Chemistry, 21(12), 2173-2177. https://doi.org/10.1021/bc100308p