Maturation and migration of dendritic cells upon stimulation with heat-killed tumor cells

Hyojeong Kim, Taek Joon Yoon, Sung Won Lee, Daesun Yun, Ji Yeon Kim, Kwang Soon Shin, Se-Ho Park, Seokmann Hong

Research output: Contribution to journalArticle

Abstract

Recently it has been reported that immunization with heat-killed tumor cells (HK vaccine) induces anti-tumor immune responses in mice. To investigate how HK vaccine elicits anti-tumor specific adaptive immunity, we examined the effect of HK vaccination on innate immune cells such as dendritic cells (DCs), which are essential for the generation of adaptive immunity. Upon stimulation with HK vaccine, DCs matured to promote not only the up-regulation of co-stimulatory molecules but also secretion of cytokine IL12. Furthermore, HK vaccine-treated DCs migrated more efficiently to draining lymph nodes compared with untreated ones. Taken together, HK vaccine can be useful as an adjuvant to activate DCs for anti-tumor immune responses.

Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalAnimal Cells and Systems
Volume16
Issue number3
DOIs
Publication statusPublished - 2012 Jun 1

Fingerprint

dendritic cells
Dendritic Cells
Tumors
Vaccines
Hot Temperature
Cells
vaccines
heat
Adaptive Immunity
Neoplasms
neoplasms
immune response
Immunization
Interleukin-12
adjuvants
lymph nodes
immunization
Vaccination
cytokines
Up-Regulation

Keywords

  • dendritic cells
  • heat-killed tumor cells
  • interleukin 12

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Animal Science and Zoology

Cite this

Kim, H., Yoon, T. J., Lee, S. W., Yun, D., Kim, J. Y., Shin, K. S., ... Hong, S. (2012). Maturation and migration of dendritic cells upon stimulation with heat-killed tumor cells. Animal Cells and Systems, 16(3), 215-223. https://doi.org/10.1080/19768354.2011.630411

Maturation and migration of dendritic cells upon stimulation with heat-killed tumor cells. / Kim, Hyojeong; Yoon, Taek Joon; Lee, Sung Won; Yun, Daesun; Kim, Ji Yeon; Shin, Kwang Soon; Park, Se-Ho; Hong, Seokmann.

In: Animal Cells and Systems, Vol. 16, No. 3, 01.06.2012, p. 215-223.

Research output: Contribution to journalArticle

Kim, Hyojeong ; Yoon, Taek Joon ; Lee, Sung Won ; Yun, Daesun ; Kim, Ji Yeon ; Shin, Kwang Soon ; Park, Se-Ho ; Hong, Seokmann. / Maturation and migration of dendritic cells upon stimulation with heat-killed tumor cells. In: Animal Cells and Systems. 2012 ; Vol. 16, No. 3. pp. 215-223.
@article{6348bbda601d406d9c28973a9fd5b6da,
title = "Maturation and migration of dendritic cells upon stimulation with heat-killed tumor cells",
abstract = "Recently it has been reported that immunization with heat-killed tumor cells (HK vaccine) induces anti-tumor immune responses in mice. To investigate how HK vaccine elicits anti-tumor specific adaptive immunity, we examined the effect of HK vaccination on innate immune cells such as dendritic cells (DCs), which are essential for the generation of adaptive immunity. Upon stimulation with HK vaccine, DCs matured to promote not only the up-regulation of co-stimulatory molecules but also secretion of cytokine IL12. Furthermore, HK vaccine-treated DCs migrated more efficiently to draining lymph nodes compared with untreated ones. Taken together, HK vaccine can be useful as an adjuvant to activate DCs for anti-tumor immune responses.",
keywords = "dendritic cells, heat-killed tumor cells, interleukin 12",
author = "Hyojeong Kim and Yoon, {Taek Joon} and Lee, {Sung Won} and Daesun Yun and Kim, {Ji Yeon} and Shin, {Kwang Soon} and Se-Ho Park and Seokmann Hong",
year = "2012",
month = "6",
day = "1",
doi = "10.1080/19768354.2011.630411",
language = "English",
volume = "16",
pages = "215--223",
journal = "Animal Cells and Systems",
issn = "1976-8354",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

TY - JOUR

T1 - Maturation and migration of dendritic cells upon stimulation with heat-killed tumor cells

AU - Kim, Hyojeong

AU - Yoon, Taek Joon

AU - Lee, Sung Won

AU - Yun, Daesun

AU - Kim, Ji Yeon

AU - Shin, Kwang Soon

AU - Park, Se-Ho

AU - Hong, Seokmann

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Recently it has been reported that immunization with heat-killed tumor cells (HK vaccine) induces anti-tumor immune responses in mice. To investigate how HK vaccine elicits anti-tumor specific adaptive immunity, we examined the effect of HK vaccination on innate immune cells such as dendritic cells (DCs), which are essential for the generation of adaptive immunity. Upon stimulation with HK vaccine, DCs matured to promote not only the up-regulation of co-stimulatory molecules but also secretion of cytokine IL12. Furthermore, HK vaccine-treated DCs migrated more efficiently to draining lymph nodes compared with untreated ones. Taken together, HK vaccine can be useful as an adjuvant to activate DCs for anti-tumor immune responses.

AB - Recently it has been reported that immunization with heat-killed tumor cells (HK vaccine) induces anti-tumor immune responses in mice. To investigate how HK vaccine elicits anti-tumor specific adaptive immunity, we examined the effect of HK vaccination on innate immune cells such as dendritic cells (DCs), which are essential for the generation of adaptive immunity. Upon stimulation with HK vaccine, DCs matured to promote not only the up-regulation of co-stimulatory molecules but also secretion of cytokine IL12. Furthermore, HK vaccine-treated DCs migrated more efficiently to draining lymph nodes compared with untreated ones. Taken together, HK vaccine can be useful as an adjuvant to activate DCs for anti-tumor immune responses.

KW - dendritic cells

KW - heat-killed tumor cells

KW - interleukin 12

UR - http://www.scopus.com/inward/record.url?scp=84863436244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863436244&partnerID=8YFLogxK

U2 - 10.1080/19768354.2011.630411

DO - 10.1080/19768354.2011.630411

M3 - Article

VL - 16

SP - 215

EP - 223

JO - Animal Cells and Systems

JF - Animal Cells and Systems

SN - 1976-8354

IS - 3

ER -