Maturation and migration of dendritic cells upon stimulation with heat-killed tumor cells

Hyojeong Kim, Taek Joon Yoon, Sung Won Lee, Daesun Yun, Ji Yeon Kim, Kwang Soon Shin, Se-Ho Park, Seokmann Hong

Research output: Contribution to journalArticle

Abstract

Recently it has been reported that immunization with heat-killed tumor cells (HK vaccine) induces anti-tumor immune responses in mice. To investigate how HK vaccine elicits anti-tumor specific adaptive immunity, we examined the effect of HK vaccination on innate immune cells such as dendritic cells (DCs), which are essential for the generation of adaptive immunity. Upon stimulation with HK vaccine, DCs matured to promote not only the up-regulation of co-stimulatory molecules but also secretion of cytokine IL12. Furthermore, HK vaccine-treated DCs migrated more efficiently to draining lymph nodes compared with untreated ones. Taken together, HK vaccine can be useful as an adjuvant to activate DCs for anti-tumor immune responses.

Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalAnimal Cells and Systems
Volume16
Issue number3
DOIs
Publication statusPublished - 2012 Jun 1

Keywords

  • dendritic cells
  • heat-killed tumor cells
  • interleukin 12

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Animal Science and Zoology

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