MCI identification by joint learning on multiple MRI data

Yue Gao, Chong Yaw Wee, Minjeong Kim, Panteleimon Giannakopoulos, Marie Louise Montandon, Sven Haller, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

18 Citations (Scopus)


The identification of subtle brain changes that are associated with mild cognitive impairment (MCI), the at-risk stage of Alzheimer’s disease, is still a challenging task. Different from existing works, which employ multimodal data (e.g., MRI, PET or CSF) to identify MCI subjects from normal elderly controls, we use four MRI sequences, including T1-weighted MRI (T1), Diffusion Tensor Imaging (DTI), Resting-State functional MRI (RS-fMRI) and Arterial Spin Labeling (ASL) perfusion imaging. Since these MRI sequences simultaneously capture various aspects of brain structure and function during clinical routine scan, it simplifies finding the relationship between subjects by incorporating the mutual information among them. To this end, we devise a hypergraph-based semisupervised learning algorithm. In particular, we first construct a hypergraph for each of MRI sequences separately using a star expansion method with both the training and testing data. A centralized learning is then performed to model the optimal relevance between subjects by incorporating mutual information between different MRI sequences. We then combine all centralized hypergraphs by learning the optimal weight of each hypergraph based on the minimum Laplacian. We apply our proposed method on a cohort of 41 consecutive MCI subjects and 63 age-and-gender matched controls with four MRI sequences. Our method achieves at least a 7.61% improvement in classification accuracy compared to state-of-theart methods using multiple MRI data.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2015 - 18th International Conference, Proceedings
EditorsJoachim Hornegger, Alejandro F. Frangi, William M. Wells, Alejandro F. Frangi, Nassir Navab, Joachim Hornegger, Nassir Navab, William M. Wells, William M. Wells, Alejandro F. Frangi, Joachim Hornegger, Nassir Navab
PublisherSpringer Verlag
Number of pages8
ISBN (Print)9783319245706, 9783319245706, 9783319245706
Publication statusPublished - 2015
Externally publishedYes
Event18th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2015 - Munich, Germany
Duration: 2015 Oct 52015 Oct 9

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other18th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2015

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)


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