Meal-related oscillations in the serum serotonin levels in healthy young men

Obin Kwon, Ji Hee Yu, Eunheui Jeong, Hyun Ju Yoo, Min Seon Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Context: Serotonin acts as a neurotransmitter in the central and enteric nervous systems, modulating psychological, metabolic and gastrointestinal functions. Serotonin is also found in the serum or plasma, indicating its potential role as a hormone. Objective: We aimed to assess the 24-hour diurnal profile of serum serotonin in relation to meal ingestion in healthy adult men. Methods: Ten healthy (5 lean and 5 obese) male subjects were enrolled in this study. Blood samples were drawn every 30-60 minutes throughout a 24-hour period to determine the serotonin levels. Three meals were provided on a fixed schedule. To confirm the effect of meal intake on serum serotonin levels, 4 subjects underwent fasting until 1500 h and were then provided a meal without notice. Results: Serum serotonin levels had distinct diurnal variations, with the highest levels early in the morning and the lowest levels in the midafternoon and during sleep. Notably, these diurnal oscillations were markedly reduced in obese subjects. Fluctuations in serum serotonin levels were associated with meal intake, and the levels peaked 30 minutes before meals and exhibited a trough during the postprandial period. Fasting blunted the meal-related oscillations in serum serotonin levels. Moreover, unexpected meal intake did not lead to a premeal increase in serum serotonin levels. Conclusions: Serum serotonin levels displayed meal-related diurnal oscillations, which were disrupted by fasting and obesity. These findings suggest the possibility that circulating serotonin modulates metabolic function in humans.

Original languageEnglish
Pages (from-to)549-555
Number of pages7
JournalClinical Endocrinology
Volume88
Issue number4
DOIs
Publication statusPublished - 2018 Apr 1

Fingerprint

Meals
Serotonin
Serum
Fasting
Postprandial Period
Enteric Nervous System
Neurotransmitter Agents
Appointments and Schedules
Sleep
Central Nervous System
Obesity
Eating
Hormones
Psychology

Keywords

  • circadian rhythm
  • meal
  • obesity
  • serotonin
  • serum

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Meal-related oscillations in the serum serotonin levels in healthy young men. / Kwon, Obin; Yu, Ji Hee; Jeong, Eunheui; Yoo, Hyun Ju; Kim, Min Seon.

In: Clinical Endocrinology, Vol. 88, No. 4, 01.04.2018, p. 549-555.

Research output: Contribution to journalArticle

Kwon, Obin ; Yu, Ji Hee ; Jeong, Eunheui ; Yoo, Hyun Ju ; Kim, Min Seon. / Meal-related oscillations in the serum serotonin levels in healthy young men. In: Clinical Endocrinology. 2018 ; Vol. 88, No. 4. pp. 549-555.
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