Meal time shift disturbs circadian rhythmicity along with metabolic and behavioral alterations in mice

Ji Ae Yoon, Dong Hee Han, Jong Yun Noh, Mi Hee Kim, Gi Hoon Son, Kyungjin Kim, Chang Ju Kim, Youngmi Kim Pak, Sehyung Cho

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In modern society, growing numbers of people are engaged in various forms of shift works or trans-meridian travels. Such circadian misalignment is known to disturb endogenous diurnal rhythms, which may lead to harmful physiological consequences including metabolic syndrome, obesity, cancer, cardiovascular disorders, and gastric disorders as well as other physical and mental disorders. However, the precise mechanism(s) underlying these changes are yet unclear. The present work, therefore examined the effects of 6 h advance or delay of usual meal time on diurnal rhythmicities in home cage activity (HCA), body temperature (BT), blood metabolic markers, glucose homeostasis, and expression of genes that are involved in cholesterol homeostasis by feeding young adult male mice in a time-restrictive manner. Delay of meal time caused locomotive hyperactivity in a significant portion (42%) of subjects, while 6 h advance caused a torpor-like symptom during the late scotophase. Accordingly, daily rhythms of blood glucose and triglyceride were differentially affected by time-restrictive feeding regimen with concurrent metabolic alterations. Along with these physiological changes, time-restrictive feeding also influenced the circadian expression patterns of low density lipoprotein receptor (LDLR) as well as most LDLR regulatory factors. Strikingly, chronic advance of meal time induced insulin resistance, while chronic delay significantly elevated blood glucose levels. Taken together, our findings indicate that persistent shifts in usual meal time impact the diurnal rhythms of carbohydrate and lipid metabolisms in addition to HCA and BT, thereby posing critical implications for the health and diseases of shift workers.

Original languageEnglish
Article numbere44053
JournalPLoS One
Volume7
Issue number8
DOIs
Publication statusPublished - 2012 Aug 27

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Periodicity
low density lipoprotein
circadian rhythm
blood glucose
body temperature
Meals
homeostasis
cages
LDL Receptors
receptors
behavior disorders
work schedules
Blood Glucose
resting periods
metabolic syndrome
mice
scotophase
carbohydrate metabolism
Circadian Rhythm
Body Temperature

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Meal time shift disturbs circadian rhythmicity along with metabolic and behavioral alterations in mice. / Yoon, Ji Ae; Han, Dong Hee; Noh, Jong Yun; Kim, Mi Hee; Son, Gi Hoon; Kim, Kyungjin; Kim, Chang Ju; Pak, Youngmi Kim; Cho, Sehyung.

In: PLoS One, Vol. 7, No. 8, e44053, 27.08.2012.

Research output: Contribution to journalArticle

Yoon, Ji Ae ; Han, Dong Hee ; Noh, Jong Yun ; Kim, Mi Hee ; Son, Gi Hoon ; Kim, Kyungjin ; Kim, Chang Ju ; Pak, Youngmi Kim ; Cho, Sehyung. / Meal time shift disturbs circadian rhythmicity along with metabolic and behavioral alterations in mice. In: PLoS One. 2012 ; Vol. 7, No. 8.
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