Measurement of pH values in human tissues by two-photon microscopy

Hee Jung Park, Chang Su Lim, Eun-Sun Kim, Ji Hee Han, Tae Hee Lee, Hoon-Jai Chun, Bong-Rae Cho

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

pH values go live! A ratiometric two-photon (TP) probe (NP1, see scheme) that has a significant TP action cross-section, high photostability, negligible toxicity, and can estimate pH values in live cells and human tissues by two-photon microscopy is described. NP1 can detect the difference in pH between live cells from the gastroesophageal junction (GEJ) and the lower esophageal sphincter of patients with and without esophagitis (see image).

Original languageEnglish
Pages (from-to)2673-2676
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number11
DOIs
Publication statusPublished - 2012 Mar 12

Fingerprint

Microscopic examination
Photons
Tissue
Toxicity
probe (NP1)

Keywords

  • fluorescent probes
  • imaging agents
  • live-cell imaging
  • naphthalenes
  • two-photon microscopy

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Measurement of pH values in human tissues by two-photon microscopy. / Park, Hee Jung; Lim, Chang Su; Kim, Eun-Sun; Han, Ji Hee; Lee, Tae Hee; Chun, Hoon-Jai; Cho, Bong-Rae.

In: Angewandte Chemie - International Edition, Vol. 51, No. 11, 12.03.2012, p. 2673-2676.

Research output: Contribution to journalArticle

Park, Hee Jung ; Lim, Chang Su ; Kim, Eun-Sun ; Han, Ji Hee ; Lee, Tae Hee ; Chun, Hoon-Jai ; Cho, Bong-Rae. / Measurement of pH values in human tissues by two-photon microscopy. In: Angewandte Chemie - International Edition. 2012 ; Vol. 51, No. 11. pp. 2673-2676.
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