Measurement of red blood cell aggregation by analysis of light transmission in a pressure-driven slit flow system

Sehyun Shin, M. S. Park, J. H. Jang, Y. H. Ku, J. S. Suh

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8 Citations (Scopus)

Abstract

The aggregation characteristics of red blood cells (RBCs) were measured using a newly developed light-transmission slit rheometer. Conventional methods of RBC disaggregation such as the rotational Couette system were replaced with a pressure-driven slit flow system with a vibrational mechanism. Using a vibration generator, one can disaggregate the RBC aggregates stored in the slit. While shear stress decreases exponentially, instantaneous pressure and the transmitted light intensity were measured over time. Applying an abrupt shearing flow after disaggregation caused a rapid elongation of the RBCs followed by loss of elongation with the decreasing shear stress. While the shear stress is further decreasing, the RBCs start to re-aggregate and the corresponding transmitted intensity increases with time, from which the aggregation indices can be obtained using a curve-fitting program.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalKorea Australia Rheology Journal
Volume16
Issue number3
Publication statusPublished - 2004 Sep 1
Externally publishedYes

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Keywords

  • Aggregation
  • Light
  • Red blood cell
  • Transmitted intensity

ASJC Scopus subject areas

  • Fluid Flow and Transfer Processes

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