Measurement of the temperature-dependent threshold shear-stress of red blood cell aggregation

Hyun Jung Lim, Jeong Hun Nam, Yong Jin Lee, Sehyun Shin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Red blood cell (RBC) aggregation is becoming an important hemorheological parameter, which typically exhibits temperature dependence. Quite recently, a critical shear-stress was proposed as a new dimensional index to represent the aggregative and disaggregative behaviors of RBCs. The present study investigated the effect of the temperature on the critical shear-stress that is required to keep RBC aggregates dispersed. The critical shear-stress was measured at various temperatures (4, 10, 20, 30, and 37 °C) through the use of a transient microfluidic aggregometry. The critical shear-stress significantly increased as the blood temperature lowered, which accorded with the increase in the low-shear blood viscosity with the lowering of the temperature. Furthermore, the critical shear-stress also showed good agreement with the threshold shear-stress, as measured in a rotational Couette flow. These findings assist in rheologically validating the critical shear-stress, as defined in the microfluidic aggregometry.

Original languageEnglish
Article number096101
JournalReview of Scientific Instruments
Volume80
Issue number9
DOIs
Publication statusPublished - 2009 Oct 12

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Cell Aggregation
erythrocytes
critical loading
shear stress
Shear stress
Blood
Agglomeration
Erythrocytes
Cells
Temperature
thresholds
Microfluidics
temperature
blood
Blood Viscosity
Rotational flow
Couette flow
Viscosity
viscosity
shear

ASJC Scopus subject areas

  • Instrumentation
  • Medicine(all)

Cite this

Measurement of the temperature-dependent threshold shear-stress of red blood cell aggregation. / Lim, Hyun Jung; Nam, Jeong Hun; Lee, Yong Jin; Shin, Sehyun.

In: Review of Scientific Instruments, Vol. 80, No. 9, 096101, 12.10.2009.

Research output: Contribution to journalArticle

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