Abstract
Red blood cell (RBC) aggregation is becoming an important hemorheological parameter, which typically exhibits temperature dependence. Quite recently, a critical shear-stress was proposed as a new dimensional index to represent the aggregative and disaggregative behaviors of RBCs. The present study investigated the effect of the temperature on the critical shear-stress that is required to keep RBC aggregates dispersed. The critical shear-stress was measured at various temperatures (4, 10, 20, 30, and 37 °C) through the use of a transient microfluidic aggregometry. The critical shear-stress significantly increased as the blood temperature lowered, which accorded with the increase in the low-shear blood viscosity with the lowering of the temperature. Furthermore, the critical shear-stress also showed good agreement with the threshold shear-stress, as measured in a rotational Couette flow. These findings assist in rheologically validating the critical shear-stress, as defined in the microfluidic aggregometry.
| Original language | English |
|---|---|
| Article number | 096101 |
| Journal | Review of Scientific Instruments |
| Volume | 80 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2009 Oct 12 |
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ASJC Scopus subject areas
- Instrumentation
- Medicine(all)
Cite this
Measurement of the temperature-dependent threshold shear-stress of red blood cell aggregation. / Lim, Hyun Jung; Nam, Jeong Hun; Lee, Yong Jin; Shin, Sehyun.
In: Review of Scientific Instruments, Vol. 80, No. 9, 096101, 12.10.2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Measurement of the temperature-dependent threshold shear-stress of red blood cell aggregation
AU - Lim, Hyun Jung
AU - Nam, Jeong Hun
AU - Lee, Yong Jin
AU - Shin, Sehyun
PY - 2009/10/12
Y1 - 2009/10/12
N2 - Red blood cell (RBC) aggregation is becoming an important hemorheological parameter, which typically exhibits temperature dependence. Quite recently, a critical shear-stress was proposed as a new dimensional index to represent the aggregative and disaggregative behaviors of RBCs. The present study investigated the effect of the temperature on the critical shear-stress that is required to keep RBC aggregates dispersed. The critical shear-stress was measured at various temperatures (4, 10, 20, 30, and 37 °C) through the use of a transient microfluidic aggregometry. The critical shear-stress significantly increased as the blood temperature lowered, which accorded with the increase in the low-shear blood viscosity with the lowering of the temperature. Furthermore, the critical shear-stress also showed good agreement with the threshold shear-stress, as measured in a rotational Couette flow. These findings assist in rheologically validating the critical shear-stress, as defined in the microfluidic aggregometry.
AB - Red blood cell (RBC) aggregation is becoming an important hemorheological parameter, which typically exhibits temperature dependence. Quite recently, a critical shear-stress was proposed as a new dimensional index to represent the aggregative and disaggregative behaviors of RBCs. The present study investigated the effect of the temperature on the critical shear-stress that is required to keep RBC aggregates dispersed. The critical shear-stress was measured at various temperatures (4, 10, 20, 30, and 37 °C) through the use of a transient microfluidic aggregometry. The critical shear-stress significantly increased as the blood temperature lowered, which accorded with the increase in the low-shear blood viscosity with the lowering of the temperature. Furthermore, the critical shear-stress also showed good agreement with the threshold shear-stress, as measured in a rotational Couette flow. These findings assist in rheologically validating the critical shear-stress, as defined in the microfluidic aggregometry.
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U2 - 10.1063/1.3223534
DO - 10.1063/1.3223534
M3 - Article
C2 - 19791972
AN - SCOPUS:70349696444
VL - 80
JO - Review of Scientific Instruments
JF - Review of Scientific Instruments
SN - 0034-6748
IS - 9
M1 - 096101
ER -