Measuring longitudinally dynamic cortex development in infants by reconstruction of consistent cortical surfaces

Gang Li, Jingxin Nie, Li Wang, Feng Shi, John H. Gilmore, Weili Lin, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Quantitative measurement of dynamic cortex development during early postnatal stages is of great importance to understand early cortical structural and functional development. Conventional methods usually independently reconstruct cortical surfaces of longitudinal images from the same infant, which often generates longitudinally-inconsistent cortical surfaces and leads to inconsistence in cortex development measurement. This paper aims to address this problem by presenting a method to reconstruct consistent cortical surfaces from longitudinal brain MR images in the first-year infants for accurate and consistent measurement of dynamic cortex development. Specifically, longitudinal development of the inner cortical surface is first modeled by a deformable sheet with elasto-plasticity property to establish longitudinally smooth correspondences of inner cortical surfaces. Then, the modeled longitudinal inner cortical surfaces are jointly deformed to locate inner and outer cortical surfaces with a spatial-temporal deformable surface. The method has been applied on 10 infants, each with 5 or 6 scans acquired at every 3 months from birth. Experimental results show that our method can accurately and consistently reconstruct dynamic cortical surfaces from longitudinal infant images, with the average surface distance as low as 0.2mm. By using our method, we can quantitatively characterize longitudinally dynamic cortical thickness development in the first-year infants.

Original languageEnglish
Title of host publicationISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro
Pages1380-1383
Number of pages4
DOIs
Publication statusPublished - 2013 Aug 22
Event2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 - San Francisco, CA, United States
Duration: 2013 Apr 72013 Apr 11

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
CountryUnited States
CitySan Francisco, CA
Period13/4/713/4/11

    Fingerprint

Keywords

  • infant cortical thickness development
  • infant longitudinal cortical surfaces

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Li, G., Nie, J., Wang, L., Shi, F., Gilmore, J. H., Lin, W., & Shen, D. (2013). Measuring longitudinally dynamic cortex development in infants by reconstruction of consistent cortical surfaces. In ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro (pp. 1380-1383). [6556790] (Proceedings - International Symposium on Biomedical Imaging). https://doi.org/10.1109/ISBI.2013.6556790