Measuring the improvement in health-related quality of life using King's health questionnaire in non-obese and obese patients with lower urinary tract symptoms after alpha-adrenergic medication: A preliminary study

Jae Heon Kim, Hoon Choi, Hwa Yeon Sun, Seung Whan Doo, Jong Hyun Yoon, Won Jae Yang, Byung Wook Yoo, Joyce Mary Kim, Soon Sun Kwon, Eun Seop Song, Hong Jun Lee, Ik Sung Lim, Yun Seob Song

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The efficacy of medical treatment among obese men with lower urinary tract symptoms (LUTS) has been less clear, especially regarding the improvement of QoL. We aimed to investigate the difference in efficacy and consequent satisfaction of life quality after medical treatment of male LUTS according to obesity. Methods. An 8-week prospective study was performed for a total of 140 patients >50 years old with International Prostate Symptom Scores (IPSS) > 12 points and prostate volume > 20 mL. Obesity was determined by either body mass index (BMI) or waist circumference (WC). Patients were divided into 2 groups according to BMI or WC. Patients received tamsulosin at a dose of 0.4 mg daily for 8 weeks. The changes from baseline in the IPSS, maximal urinary flow rate (Qmax), post-void residual volume, questionnaire of quality of life (QoL), and King's Health Questionnaire (KHQ) were analyzed. Results: Of the 150 enrolled patients, 96 completed the study. Seventy-five patients (78.1%) had BMI ≥ 23 kg/m2, and 24 (25.0%) had WC > 90 cm. Overall, the IPSS, IPSS QoL, and total KHQ showed significant improvement. Obese (BMI ≥ 23 kg/m2) and non-obese (BMI < 23 kg/m2) both showed improvement of the IPSS and IPSS QoL scores, but only the obese (BMI ≥ 23 kg/m2) group showed improvement of the total KHQ score (P < 0.001 vs. P = 0.55). Only the obese (WC > 90 cm) group showed improvement of the IPSS and total KHQ scores (P < 0.001). Conclusions: Our preliminary study showed the different efficacy of an alpha-blocker for improvement of LUTS and life quality according to obesity. Obese patients, defined by BMI or WC, showed the tendency toward a more favorable improvement of LUTS and life quality. Trial registration. Current Controlled Trials 2010-058. Registered 2 September 2010 in Soonchunhyang Univeristy Hospital.

Original languageEnglish
Article number60
JournalBMC Urology
Volume14
Issue number1
DOIs
Publication statusPublished - 2014 Aug 6

Fingerprint

Lower Urinary Tract Symptoms
Adrenergic Agents
Prostate
Body Mass Index
Quality of Life
Waist Circumference
Health
Obesity
tamsulosin
Residual Volume
Surveys and Questionnaires
Prospective Studies

Keywords

  • Alpha-blocker
  • Body mass index
  • Prostatic hyperplasia
  • Waist circumference

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology

Cite this

Measuring the improvement in health-related quality of life using King's health questionnaire in non-obese and obese patients with lower urinary tract symptoms after alpha-adrenergic medication : A preliminary study. / Kim, Jae Heon; Choi, Hoon; Sun, Hwa Yeon; Doo, Seung Whan; Yoon, Jong Hyun; Yang, Won Jae; Yoo, Byung Wook; Kim, Joyce Mary; Kwon, Soon Sun; Song, Eun Seop; Lee, Hong Jun; Lim, Ik Sung; Song, Yun Seob.

In: BMC Urology, Vol. 14, No. 1, 60, 06.08.2014.

Research output: Contribution to journalArticle

Kim, Jae Heon ; Choi, Hoon ; Sun, Hwa Yeon ; Doo, Seung Whan ; Yoon, Jong Hyun ; Yang, Won Jae ; Yoo, Byung Wook ; Kim, Joyce Mary ; Kwon, Soon Sun ; Song, Eun Seop ; Lee, Hong Jun ; Lim, Ik Sung ; Song, Yun Seob. / Measuring the improvement in health-related quality of life using King's health questionnaire in non-obese and obese patients with lower urinary tract symptoms after alpha-adrenergic medication : A preliminary study. In: BMC Urology. 2014 ; Vol. 14, No. 1.
@article{dcf859ae5b034962a221668d468c2c7a,
title = "Measuring the improvement in health-related quality of life using King's health questionnaire in non-obese and obese patients with lower urinary tract symptoms after alpha-adrenergic medication: A preliminary study",
abstract = "Background: The efficacy of medical treatment among obese men with lower urinary tract symptoms (LUTS) has been less clear, especially regarding the improvement of QoL. We aimed to investigate the difference in efficacy and consequent satisfaction of life quality after medical treatment of male LUTS according to obesity. Methods. An 8-week prospective study was performed for a total of 140 patients >50 years old with International Prostate Symptom Scores (IPSS) > 12 points and prostate volume > 20 mL. Obesity was determined by either body mass index (BMI) or waist circumference (WC). Patients were divided into 2 groups according to BMI or WC. Patients received tamsulosin at a dose of 0.4 mg daily for 8 weeks. The changes from baseline in the IPSS, maximal urinary flow rate (Qmax), post-void residual volume, questionnaire of quality of life (QoL), and King's Health Questionnaire (KHQ) were analyzed. Results: Of the 150 enrolled patients, 96 completed the study. Seventy-five patients (78.1{\%}) had BMI ≥ 23 kg/m2, and 24 (25.0{\%}) had WC > 90 cm. Overall, the IPSS, IPSS QoL, and total KHQ showed significant improvement. Obese (BMI ≥ 23 kg/m2) and non-obese (BMI < 23 kg/m2) both showed improvement of the IPSS and IPSS QoL scores, but only the obese (BMI ≥ 23 kg/m2) group showed improvement of the total KHQ score (P < 0.001 vs. P = 0.55). Only the obese (WC > 90 cm) group showed improvement of the IPSS and total KHQ scores (P < 0.001). Conclusions: Our preliminary study showed the different efficacy of an alpha-blocker for improvement of LUTS and life quality according to obesity. Obese patients, defined by BMI or WC, showed the tendency toward a more favorable improvement of LUTS and life quality. Trial registration. Current Controlled Trials 2010-058. Registered 2 September 2010 in Soonchunhyang Univeristy Hospital.",
keywords = "Alpha-blocker, Body mass index, Prostatic hyperplasia, Waist circumference",
author = "Kim, {Jae Heon} and Hoon Choi and Sun, {Hwa Yeon} and Doo, {Seung Whan} and Yoon, {Jong Hyun} and Yang, {Won Jae} and Yoo, {Byung Wook} and Kim, {Joyce Mary} and Kwon, {Soon Sun} and Song, {Eun Seop} and Lee, {Hong Jun} and Lim, {Ik Sung} and Song, {Yun Seob}",
year = "2014",
month = "8",
day = "6",
doi = "10.1186/1471-2490-14-60",
language = "English",
volume = "14",
journal = "BMC Urology",
issn = "1471-2490",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Measuring the improvement in health-related quality of life using King's health questionnaire in non-obese and obese patients with lower urinary tract symptoms after alpha-adrenergic medication

T2 - A preliminary study

AU - Kim, Jae Heon

AU - Choi, Hoon

AU - Sun, Hwa Yeon

AU - Doo, Seung Whan

AU - Yoon, Jong Hyun

AU - Yang, Won Jae

AU - Yoo, Byung Wook

AU - Kim, Joyce Mary

AU - Kwon, Soon Sun

AU - Song, Eun Seop

AU - Lee, Hong Jun

AU - Lim, Ik Sung

AU - Song, Yun Seob

PY - 2014/8/6

Y1 - 2014/8/6

N2 - Background: The efficacy of medical treatment among obese men with lower urinary tract symptoms (LUTS) has been less clear, especially regarding the improvement of QoL. We aimed to investigate the difference in efficacy and consequent satisfaction of life quality after medical treatment of male LUTS according to obesity. Methods. An 8-week prospective study was performed for a total of 140 patients >50 years old with International Prostate Symptom Scores (IPSS) > 12 points and prostate volume > 20 mL. Obesity was determined by either body mass index (BMI) or waist circumference (WC). Patients were divided into 2 groups according to BMI or WC. Patients received tamsulosin at a dose of 0.4 mg daily for 8 weeks. The changes from baseline in the IPSS, maximal urinary flow rate (Qmax), post-void residual volume, questionnaire of quality of life (QoL), and King's Health Questionnaire (KHQ) were analyzed. Results: Of the 150 enrolled patients, 96 completed the study. Seventy-five patients (78.1%) had BMI ≥ 23 kg/m2, and 24 (25.0%) had WC > 90 cm. Overall, the IPSS, IPSS QoL, and total KHQ showed significant improvement. Obese (BMI ≥ 23 kg/m2) and non-obese (BMI < 23 kg/m2) both showed improvement of the IPSS and IPSS QoL scores, but only the obese (BMI ≥ 23 kg/m2) group showed improvement of the total KHQ score (P < 0.001 vs. P = 0.55). Only the obese (WC > 90 cm) group showed improvement of the IPSS and total KHQ scores (P < 0.001). Conclusions: Our preliminary study showed the different efficacy of an alpha-blocker for improvement of LUTS and life quality according to obesity. Obese patients, defined by BMI or WC, showed the tendency toward a more favorable improvement of LUTS and life quality. Trial registration. Current Controlled Trials 2010-058. Registered 2 September 2010 in Soonchunhyang Univeristy Hospital.

AB - Background: The efficacy of medical treatment among obese men with lower urinary tract symptoms (LUTS) has been less clear, especially regarding the improvement of QoL. We aimed to investigate the difference in efficacy and consequent satisfaction of life quality after medical treatment of male LUTS according to obesity. Methods. An 8-week prospective study was performed for a total of 140 patients >50 years old with International Prostate Symptom Scores (IPSS) > 12 points and prostate volume > 20 mL. Obesity was determined by either body mass index (BMI) or waist circumference (WC). Patients were divided into 2 groups according to BMI or WC. Patients received tamsulosin at a dose of 0.4 mg daily for 8 weeks. The changes from baseline in the IPSS, maximal urinary flow rate (Qmax), post-void residual volume, questionnaire of quality of life (QoL), and King's Health Questionnaire (KHQ) were analyzed. Results: Of the 150 enrolled patients, 96 completed the study. Seventy-five patients (78.1%) had BMI ≥ 23 kg/m2, and 24 (25.0%) had WC > 90 cm. Overall, the IPSS, IPSS QoL, and total KHQ showed significant improvement. Obese (BMI ≥ 23 kg/m2) and non-obese (BMI < 23 kg/m2) both showed improvement of the IPSS and IPSS QoL scores, but only the obese (BMI ≥ 23 kg/m2) group showed improvement of the total KHQ score (P < 0.001 vs. P = 0.55). Only the obese (WC > 90 cm) group showed improvement of the IPSS and total KHQ scores (P < 0.001). Conclusions: Our preliminary study showed the different efficacy of an alpha-blocker for improvement of LUTS and life quality according to obesity. Obese patients, defined by BMI or WC, showed the tendency toward a more favorable improvement of LUTS and life quality. Trial registration. Current Controlled Trials 2010-058. Registered 2 September 2010 in Soonchunhyang Univeristy Hospital.

KW - Alpha-blocker

KW - Body mass index

KW - Prostatic hyperplasia

KW - Waist circumference

UR - http://www.scopus.com/inward/record.url?scp=84906548723&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906548723&partnerID=8YFLogxK

U2 - 10.1186/1471-2490-14-60

DO - 10.1186/1471-2490-14-60

M3 - Article

C2 - 25099073

AN - SCOPUS:84906548723

VL - 14

JO - BMC Urology

JF - BMC Urology

SN - 1471-2490

IS - 1

M1 - 60

ER -