Mechanical characterization of biomole-cular fibrils using molecular dynamics

Hyun Joon Chang, Gwonchan Yoon, Myeong Sang Lee, Jae In Kim, Incheol Baek, Sung Soo Na, Kilho Eom

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Amyloid fibrils exhibit excellent mechanical properties such as elastic modulus in the order of 10 GPa, which also play a critical role in various disease expressions. These excellent mechanical properties of amyloid fibrils are related to their functional role in disease expression. However, it is not clearly understood how amyloid fibrils can exhibit remarkable mechanical properties. In this study, mechanical characterization of biomolecular nanofibrils using molecular dynamics (MD) simulation is examined and studied with respect to its structural hierarchies and structural shapes by coarse-grained normal mode analysis. The results show that the amyloid fibril can achieve the excellent bending rigidity and moreover, the length-dependent mechanical properties of amyloids are found.

Original languageEnglish
Title of host publication20th International Congress on Sound and Vibration 2013, ICSV 2013
PublisherInternational Institute of Acoustics and Vibrations
Pages1321-1324
Number of pages4
Volume2
Publication statusPublished - 2013 Jan 1
Event20th International Congress on Sound and Vibration 2013, ICSV 2013 - Bangkok, Thailand
Duration: 2013 Jul 72013 Jul 11

Other

Other20th International Congress on Sound and Vibration 2013, ICSV 2013
CountryThailand
CityBangkok
Period13/7/713/7/11

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ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Chang, H. J., Yoon, G., Lee, M. S., Kim, J. I., Baek, I., Na, S. S., & Eom, K. (2013). Mechanical characterization of biomole-cular fibrils using molecular dynamics. In 20th International Congress on Sound and Vibration 2013, ICSV 2013 (Vol. 2, pp. 1321-1324). International Institute of Acoustics and Vibrations.