Mechanical Force for the Transformation of Aziridine into Imine

Sangmin Jung, Hyo Jae Yoon

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Force-selective mechanochemical reactions may be important for applications in polymer mechanochemistry, yet it is difficult to achieve such reactions. This paper reports that cis-N-phthalimidoaziridine incorporated into a macromolecular backbone undergoes migration of N-phthalimido group to afford imine under mechanochemical condition and not thermal one. The imine is further hydrolyzed by water bifurcating into amine and aldehyde. These structural transformations are confirmed by 1H NMR and FT-IR spectroscopic analyses. Computational simulations are conducted for the aziridine mechanophore to propose the mechanism of reaction and define the substrate scope of reaction.

Original languageEnglish
Pages (from-to)23564-23568
Number of pages5
JournalAngewandte Chemie - International Edition
Volume60
Issue number44
DOIs
Publication statusPublished - 2021 Oct 25

Keywords

  • aziridines
  • mechanochemistry
  • polymers
  • reaction mechanisms
  • structure elucidation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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