TY - JOUR
T1 - Mechanisms of aging and the preventive effects of resveratrol on age-related diseases
AU - Pyo, In Soo
AU - Yun, Suyeon
AU - Yoon, Ye Eun
AU - Choi, Jung Won
AU - Lee, Sung Joon
N1 - Funding Information:
Funding: This work was supported by a National Research Foundation of Korea (NRF) grants funded by the Korean government (MSIT) (Grant Nos. NRF-2019R1A2C3005227 and NRF-2018R1A4A1022589). This research was supported by the School of Life Sciences and Biotechnology for BK21 PLUS, Korea University.
PY - 2020/10
Y1 - 2020/10
N2 - Aging gradually decreases cellular biological functions and increases the risk of age-related diseases. Cancer, type 2 diabetes mellitus, cardiovascular disease, and neurological disorders are commonly classified as age-related diseases that can affect the lifespan and health of individuals. Aging is a complicated and sophisticated biological process involving damage to biochemical macromolecules including DNA, proteins, and cellular organelles such as mitochondria. Aging causes multiple alterations in biological processes including energy metabolism and nutrient sensing, thus reducing cell proliferation and causing cellular senescence. Among the polyphenolic phytochemicals, resveratrol is believed to reduce the negative effects of the aging process through its multiple biological activities. Resveratrol increases the lifespan of several model organisms by regulating oxidative stress, energy metabolism, nutrient sensing, and epigenetics, primarily by activating sirtuin 1. This review summarizes the most important biological mechanisms of aging, and the ability of resveratrol to prevent age-related diseases.
AB - Aging gradually decreases cellular biological functions and increases the risk of age-related diseases. Cancer, type 2 diabetes mellitus, cardiovascular disease, and neurological disorders are commonly classified as age-related diseases that can affect the lifespan and health of individuals. Aging is a complicated and sophisticated biological process involving damage to biochemical macromolecules including DNA, proteins, and cellular organelles such as mitochondria. Aging causes multiple alterations in biological processes including energy metabolism and nutrient sensing, thus reducing cell proliferation and causing cellular senescence. Among the polyphenolic phytochemicals, resveratrol is believed to reduce the negative effects of the aging process through its multiple biological activities. Resveratrol increases the lifespan of several model organisms by regulating oxidative stress, energy metabolism, nutrient sensing, and epigenetics, primarily by activating sirtuin 1. This review summarizes the most important biological mechanisms of aging, and the ability of resveratrol to prevent age-related diseases.
KW - Age-related diseases
KW - Aging
KW - Resveratrol
UR - http://www.scopus.com/inward/record.url?scp=85092449490&partnerID=8YFLogxK
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U2 - 10.3390/molecules25204649
DO - 10.3390/molecules25204649
M3 - Review article
C2 - 33053864
AN - SCOPUS:85092449490
VL - 25
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 20
M1 - 4649
ER -
