Mechanisms of (-)epigallocatechin-3-gallate for antiobesity

Hyun Seuk Moon, Mohammed Akbar, Cheol Heui Yun, Chong Su Cho

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


It has long been recognized that obesity is major risk factor for numbers of disorders including diabetes, hypertension, and heart diseases. For these, adipocytes play a central role in maintaining lipid homeostasis and energy balance in vertebrates by storing triacylglycerols (TGs) and releasing free fatty acids (FFAs) in response to changes in energy demands. Last few years, numerous studies regarding green tea catechins (GTCs) are reported to exhibit a variety of biological activities including cancer prevention and cardiovascular health. Furthermore, the obesity-preventive effects of green tea and its main constituent especially (-)-epigallocatechin-3-gallate (EGCG) are widely supported by results from epidemiological, cell culture, animal, and clinical studies. In this review, the biological activities and multiple mechanisms of EGCG in vitro and in vivo studies including animal models and clinical observations are explained.

Original languageEnglish
Title of host publicationWeight Control and Slimming Ingredients in Food Technology
Number of pages23
ISBN (Electronic)9780813819679
ISBN (Print)9780813813233
Publication statusPublished - 2009 Dec 8
Externally publishedYes


  • (-)-epigallocatechin-3-gallate (EGCG)
  • Adipocytes and obesity
  • Antiobesity mechanisms of EGCG
  • EGCG inhibition of lipid-related enzymes in cell-free systems
  • Green tea catechins (GTCs)
  • High-density lipoprotein (HDL) levels
  • Insulin-potentiating activity by green tea
  • Obesity-preventive effects of green tea and main compound EGCG

ASJC Scopus subject areas

  • Engineering(all)
  • Agricultural and Biological Sciences(all)


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