Mechanisms of glucocorticoid action in chronic rhinosinusitis

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

The innate immune system and its complex interplay with the adaptive immune system are increasingly being recognized as important factors in the pathogenesis of chronic rhinosinusitis (CRS). Adaptive immune components, including resident and inflammatory cells, and their associated mediators, have been the subject of most research in CRS. For this reason, theories of CRS pathogenesis have involved the concept that inflammation, rather than infection, is the dominant etiologic factor in CRS. Therefore, glucocorticoids are increasingly used to treat CRS. This review will outline our current knowledge of action mode of glucocorticoids in CRS.

Original languageEnglish
Pages (from-to)534-537
Number of pages4
JournalAllergy, Asthma and Immunology Research
Volume7
Issue number6
DOIs
Publication statusPublished - 2015 Jan 1

Keywords

  • Chronic rhinosinusitis
  • Cytokines
  • Glucocorticoid receptor
  • Glucocorticoids

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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