Mechanisms of glucocorticoid action in chronic rhinosinusitis

Sang Hag Lee

    Research output: Contribution to journalReview articlepeer-review

    22 Citations (Scopus)

    Abstract

    The innate immune system and its complex interplay with the adaptive immune system are increasingly being recognized as important factors in the pathogenesis of chronic rhinosinusitis (CRS). Adaptive immune components, including resident and inflammatory cells, and their associated mediators, have been the subject of most research in CRS. For this reason, theories of CRS pathogenesis have involved the concept that inflammation, rather than infection, is the dominant etiologic factor in CRS. Therefore, glucocorticoids are increasingly used to treat CRS. This review will outline our current knowledge of action mode of glucocorticoids in CRS.

    Original languageEnglish
    Pages (from-to)534-537
    Number of pages4
    JournalAllergy, Asthma and Immunology Research
    Volume7
    Issue number6
    DOIs
    Publication statusPublished - 2015

    Keywords

    • Chronic rhinosinusitis
    • Cytokines
    • Glucocorticoid receptor
    • Glucocorticoids

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Pulmonary and Respiratory Medicine

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