TY - JOUR
T1 - Mechanistic mammalian target of rapamycin (MTOR) cell signaling
T2 - Effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses
AU - Bazer, Fuller W.
AU - Song, Gwonhwa
AU - Kim, Jinyoung
AU - Erikson, David W.
AU - Johnson, Greg A.
AU - Burghardt, Robert C.
AU - Gao, Haijun
AU - Carey Satterfield, M.
AU - Spencer, Thomas E.
AU - Wu, Guoyao
N1 - Funding Information:
Supported by USDA CSREES National Research Initiative Grant 2006-35203-17283, National Research Initiative Competitive Grant No. 2006-35203-17283 from the USDA National Institute of Food and Agriculture , and the World Class University (WCU) program (R31–10056) through the National Research Foundation of Korea funded by the Ministry of Education, Science, and Technology .
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/5/6
Y1 - 2012/5/6
N2 - Morphological differentiation of uterine glands in mammals is a postnatal event vulnerable to adverse effects of endocrine disruptors. Exposure of ewe lambs to a progestin from birth to postnatal day 56 prevents development of uterine glands and, as adults, the ewes are unable to exhibit estrous cycles or maintain pregnancy. Uterine epithelia secrete proteins and transport nutrients into the uterine lumen necessary for conceptus development, pregnancy recognition signaling and implantation, including arginine and secreted phosphoprotein 1 (SPP1). Arginine can be metabolized to nitric oxide and to polyamines or act directly to activate MTOR cell signaling to stimulate proliferation, migration, and mRNA translation in trophectoderm cells. SPP1 binds αvβ3 and α5β1 integrins and induces focal adhesion assembly, adhesion and migration of conceptus trophectoderm cells during implantation. Thus, arginine and SPP1 mediate growth, migration, cytoskeletal remodeling and adhesion of trophectoderm essential for pregnancy recognition signaling and implantation.
AB - Morphological differentiation of uterine glands in mammals is a postnatal event vulnerable to adverse effects of endocrine disruptors. Exposure of ewe lambs to a progestin from birth to postnatal day 56 prevents development of uterine glands and, as adults, the ewes are unable to exhibit estrous cycles or maintain pregnancy. Uterine epithelia secrete proteins and transport nutrients into the uterine lumen necessary for conceptus development, pregnancy recognition signaling and implantation, including arginine and secreted phosphoprotein 1 (SPP1). Arginine can be metabolized to nitric oxide and to polyamines or act directly to activate MTOR cell signaling to stimulate proliferation, migration, and mRNA translation in trophectoderm cells. SPP1 binds αvβ3 and α5β1 integrins and induces focal adhesion assembly, adhesion and migration of conceptus trophectoderm cells during implantation. Thus, arginine and SPP1 mediate growth, migration, cytoskeletal remodeling and adhesion of trophectoderm essential for pregnancy recognition signaling and implantation.
KW - Amino acids
KW - Conceptus
KW - Endocrine disruptor
KW - Glucose
KW - MTOR
KW - Pregnancy
KW - Secreted phosphoprotein 1
KW - Uterus
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U2 - 10.1016/j.mce.2011.08.026
DO - 10.1016/j.mce.2011.08.026
M3 - Review article
C2 - 21907263
AN - SCOPUS:84858285452
VL - 354
SP - 22
EP - 33
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 1-2
ER -