Abstract
Morphological differentiation of uterine glands in mammals is a postnatal event vulnerable to adverse effects of endocrine disruptors. Exposure of ewe lambs to a progestin from birth to postnatal day 56 prevents development of uterine glands and, as adults, the ewes are unable to exhibit estrous cycles or maintain pregnancy. Uterine epithelia secrete proteins and transport nutrients into the uterine lumen necessary for conceptus development, pregnancy recognition signaling and implantation, including arginine and secreted phosphoprotein 1 (SPP1). Arginine can be metabolized to nitric oxide and to polyamines or act directly to activate MTOR cell signaling to stimulate proliferation, migration, and mRNA translation in trophectoderm cells. SPP1 binds αvβ3 and α5β1 integrins and induces focal adhesion assembly, adhesion and migration of conceptus trophectoderm cells during implantation. Thus, arginine and SPP1 mediate growth, migration, cytoskeletal remodeling and adhesion of trophectoderm essential for pregnancy recognition signaling and implantation.
| Original language | English |
|---|---|
| Pages (from-to) | 22-33 |
| Number of pages | 12 |
| Journal | Molecular and Cellular Endocrinology |
| Volume | 354 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2012 May 6 |
| Externally published | Yes |
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Keywords
- Amino acids
- Conceptus
- Endocrine disruptor
- Glucose
- MTOR
- Pregnancy
- Secreted phosphoprotein 1
- Uterus
ASJC Scopus subject areas
- Endocrinology
- Molecular Biology
- Biochemistry
Cite this
Mechanistic mammalian target of rapamycin (MTOR) cell signaling : Effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses. / Bazer, Fuller W.; Song, Gwonhwa; Kim, Jinyoung; Erikson, David W.; Johnson, Greg A.; Burghardt, Robert C.; Gao, Haijun; Carey Satterfield, M.; Spencer, Thomas E.; Wu, Guoyao.
In: Molecular and Cellular Endocrinology, Vol. 354, No. 1-2, 06.05.2012, p. 22-33.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanistic mammalian target of rapamycin (MTOR) cell signaling
T2 - Effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses
AU - Bazer, Fuller W.
AU - Song, Gwonhwa
AU - Kim, Jinyoung
AU - Erikson, David W.
AU - Johnson, Greg A.
AU - Burghardt, Robert C.
AU - Gao, Haijun
AU - Carey Satterfield, M.
AU - Spencer, Thomas E.
AU - Wu, Guoyao
PY - 2012/5/6
Y1 - 2012/5/6
N2 - Morphological differentiation of uterine glands in mammals is a postnatal event vulnerable to adverse effects of endocrine disruptors. Exposure of ewe lambs to a progestin from birth to postnatal day 56 prevents development of uterine glands and, as adults, the ewes are unable to exhibit estrous cycles or maintain pregnancy. Uterine epithelia secrete proteins and transport nutrients into the uterine lumen necessary for conceptus development, pregnancy recognition signaling and implantation, including arginine and secreted phosphoprotein 1 (SPP1). Arginine can be metabolized to nitric oxide and to polyamines or act directly to activate MTOR cell signaling to stimulate proliferation, migration, and mRNA translation in trophectoderm cells. SPP1 binds αvβ3 and α5β1 integrins and induces focal adhesion assembly, adhesion and migration of conceptus trophectoderm cells during implantation. Thus, arginine and SPP1 mediate growth, migration, cytoskeletal remodeling and adhesion of trophectoderm essential for pregnancy recognition signaling and implantation.
AB - Morphological differentiation of uterine glands in mammals is a postnatal event vulnerable to adverse effects of endocrine disruptors. Exposure of ewe lambs to a progestin from birth to postnatal day 56 prevents development of uterine glands and, as adults, the ewes are unable to exhibit estrous cycles or maintain pregnancy. Uterine epithelia secrete proteins and transport nutrients into the uterine lumen necessary for conceptus development, pregnancy recognition signaling and implantation, including arginine and secreted phosphoprotein 1 (SPP1). Arginine can be metabolized to nitric oxide and to polyamines or act directly to activate MTOR cell signaling to stimulate proliferation, migration, and mRNA translation in trophectoderm cells. SPP1 binds αvβ3 and α5β1 integrins and induces focal adhesion assembly, adhesion and migration of conceptus trophectoderm cells during implantation. Thus, arginine and SPP1 mediate growth, migration, cytoskeletal remodeling and adhesion of trophectoderm essential for pregnancy recognition signaling and implantation.
KW - Amino acids
KW - Conceptus
KW - Endocrine disruptor
KW - Glucose
KW - MTOR
KW - Pregnancy
KW - Secreted phosphoprotein 1
KW - Uterus
UR - http://www.scopus.com/inward/record.url?scp=84858285452&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858285452&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2011.08.026
DO - 10.1016/j.mce.2011.08.026
M3 - Article
VL - 354
SP - 22
EP - 33
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 1-2
ER -