Mechano-active cartilage tissue engineering: The effect of dynamic compressive stimulation

Youngmee Jung, Soo Hyun Kim, Sang Heon Kim, Young Ha Kim, Jun Xie, Takehisa Matsuda, Byoung Goo Min

Research output: Contribution to journalArticle

Abstract

Mechano-active scaffolds were fabricated from very elastic poly(lactide-co-carprolactone) by a gel-pressing method. The scaffolds were seeded with bone marrow stromal cells and the continuous compressive deformation was applied to cell-polymer constructs in the chondrogenic media. Then, they were implanted in nude mice subcutaneously to evaluate for the effect of dynamic compression for regeneration of cartilage. From the biochemical analyses, chondrogenic differentiation was sustained and enhanced significantly and chondral extracellular matrix was increased through mechanical stimulation. Histological analyses showed that implants stimulated mechanically formed mature and well-developed cartilaginous tissue, as evidenced by bone marrow derived chondrocytes within lacunae. Consequently, the periodic application of dynamic compression can encourage bone marrow stromal cells to differentiation to chondrogenic lineage and to maintain their phenotypes.

Original languageEnglish
Pages (from-to)409-412
Number of pages4
JournalKey Engineering Materials
Volume342-343
Publication statusPublished - 2007 Apr 16
Externally publishedYes

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Keywords

  • Bioreactor in compressive mode
  • Bone marrow stromal cells
  • Cartilage tissue engineering
  • Elastic poly-(I-lactide-co-ε-caprolactone) scaffold

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

Jung, Y., Kim, S. H., Kim, S. H., Kim, Y. H., Xie, J., Matsuda, T., & Min, B. G. (2007). Mechano-active cartilage tissue engineering: The effect of dynamic compressive stimulation. Key Engineering Materials, 342-343, 409-412.