MeCP2 Caught Moonlighting as a Suppressor of MicroRNA Processing

Jae Sung Woo, V. Narry Kim

Research output: Contribution to journalShort survey

6 Citations (Scopus)

Abstract

MeCP2 is a transcriptional regulator important for neurodevelopment and is involved in Rett syndrome and autism. In this issue of Developmental Cell, Cheng and colleagues (2014) report that MeCP2 also regulates microRNA biogenesis. MeCP2 phosphorylation induces a direct interaction with DGCR8, leading to reduced microRNA processing and retardation of dendritic growth.

Original languageEnglish
Pages (from-to)477-478
Number of pages2
JournalDevelopmental Cell
Volume28
Issue number5
DOIs
Publication statusPublished - 2014 Mar 10
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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