Medial temporal atrophy and memory dysfunction in poststroke cognitive impairment-no dementia

Beom Joon Kim, Mi Young Oh, Myung Suk Jang, Moon Ku Han, Jisung Lee, Juneyoung Lee, Yeonwook Kang, Kyung Ho Yu, Byung Chul Lee, Sangyun Kim, Byung Woo Yoon, Hee Joon Bae

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background and Purpose It was recently reported that the prevalence of poststroke memory dysfunction might be higher than previously thought. Stroke may exist concomitantly with underlying Alzheimer's disease (AD), and so we determined whether post-stroke memory dysfunction indicates manifestation of underlying subclinical AD. Methods Of 1201 patients in a prospective cognitive assessment database, we enrolled subjects with poststroke amnestic vascular cognitive impairment-no dementia (aVCIND; n=48), poststroke nonamnestic vascular cognitive impairment-no dementia (naVCIND; n=50), and nonstroke amnestic mild cognitive impairment (aMCI; n=65). All subjects had cognitive deficits, but did not meet the criteria for dementia. A standardized neuropsychological test battery and magnetic resonance imaging were performed at least 90 days after the index stroke (mean, 473 days). Visual assessment of medial temporal atrophy (MTA) was used as a measure of underlying AD pathology. Results The MTA score was significantly lower in the naVCIND group (0.64±0.85, mean±SD) than in the aVCIND (1.10±1.08) and aMCI (1.45±1.13; p<0.01) groups. Multivariable ordinal logistic regression analysis revealed that compared with naVCIND, aVCIND [odds ratio (OR)=2.69; 95% confidence interval (CI)=1.21-5.99] and aMCI (OR=5.20; 95% CI=2.41-11.23) were significantly associated with increasing severity of MTA. Conclusions Our findings show that compared with poststroke naVCIND, the odds of having more-severe MTA were increased for poststroke aVCIND and nonstroke aMCI.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalJournal of Clinical Neurology (Korea)
Volume8
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

Fingerprint

Atrophy
Dementia
Alzheimer Disease
Stroke
Blood Vessels
Odds Ratio
Confidence Intervals
Neuropsychological Tests
Logistic Models
Regression Analysis
Magnetic Resonance Imaging
Databases
Pathology
Cognitive Dysfunction

Keywords

  • Memory dysfunction
  • Poststroke dementia
  • Stroke
  • Vascular cognitive impairment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Medial temporal atrophy and memory dysfunction in poststroke cognitive impairment-no dementia. / Kim, Beom Joon; Oh, Mi Young; Jang, Myung Suk; Han, Moon Ku; Lee, Jisung; Lee, Juneyoung; Kang, Yeonwook; Yu, Kyung Ho; Lee, Byung Chul; Kim, Sangyun; Yoon, Byung Woo; Bae, Hee Joon.

In: Journal of Clinical Neurology (Korea), Vol. 8, No. 1, 01.01.2012, p. 43-50.

Research output: Contribution to journalArticle

Kim, BJ, Oh, MY, Jang, MS, Han, MK, Lee, J, Lee, J, Kang, Y, Yu, KH, Lee, BC, Kim, S, Yoon, BW & Bae, HJ 2012, 'Medial temporal atrophy and memory dysfunction in poststroke cognitive impairment-no dementia', Journal of Clinical Neurology (Korea), vol. 8, no. 1, pp. 43-50. https://doi.org/10.3988/jcn.2012.8.1.43
Kim, Beom Joon ; Oh, Mi Young ; Jang, Myung Suk ; Han, Moon Ku ; Lee, Jisung ; Lee, Juneyoung ; Kang, Yeonwook ; Yu, Kyung Ho ; Lee, Byung Chul ; Kim, Sangyun ; Yoon, Byung Woo ; Bae, Hee Joon. / Medial temporal atrophy and memory dysfunction in poststroke cognitive impairment-no dementia. In: Journal of Clinical Neurology (Korea). 2012 ; Vol. 8, No. 1. pp. 43-50.
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