Median effective dose of nefopam to treat postoperative pain in patients who have undergone laparoscopic cholecystectomy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: Nefopam is thought to reduce postoperative pain; however, the evidence is insufficient. The recommended dose is 20 mg, and the median effective dose (ED50) in the surgical setting reportedly ranges from 17 to 28 mg. However, nefopam frequently produces inadequate postoperative analgesia. We evaluated the ED50 of nefopam as a single agent in patients undergoing laparoscopic cholecystectomy. Methods: Twenty-nine patients were scheduled for laparoscopic cholecystectomy. Postoperative pain was evaluated using a numerical pain scale (NPS). When the NPS score was >3, patients were administered a predetermined dose of nefopam. The dose was calculated using the up-and-down allocation technique based on the previous response. The initial dose was 28 mg, with adjustment intervals of 5 mg. An effective response was defined as a decrease in the NPS score to <3 at 30 minutes after infusion. Results: The ED50 of nefopam was 62.1 mg (95% confidence interval, 52.9–72.9 mg). Eight patients reported pain upon injection, and three were excluded due to severe injection pain and phlebitis. Conclusions: The estimated ED50 was higher than the predetermined dose based on previous studies. We recommend that the dose of nefopam be chosen after careful consideration of individual variations and clinical settings.

Original languageEnglish
Pages (from-to)3684-3691
Number of pages8
JournalJournal of International Medical Research
Volume46
Issue number9
DOIs
Publication statusPublished - 2018 Sep 1

Fingerprint

Nefopam
Laparoscopic Cholecystectomy
Postoperative Pain
Pain
Social Adjustment
Phlebitis
Injections
Proxy
Analgesia
Confidence Intervals

Keywords

  • cholecystectomy
  • median effective dose
  • Nefopam
  • numerical pain scale
  • pain
  • postoperative

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

Cite this

@article{2ea6fe76abbc4a2586b4b11ede8d9c60,
title = "Median effective dose of nefopam to treat postoperative pain in patients who have undergone laparoscopic cholecystectomy",
abstract = "Objective: Nefopam is thought to reduce postoperative pain; however, the evidence is insufficient. The recommended dose is 20 mg, and the median effective dose (ED50) in the surgical setting reportedly ranges from 17 to 28 mg. However, nefopam frequently produces inadequate postoperative analgesia. We evaluated the ED50 of nefopam as a single agent in patients undergoing laparoscopic cholecystectomy. Methods: Twenty-nine patients were scheduled for laparoscopic cholecystectomy. Postoperative pain was evaluated using a numerical pain scale (NPS). When the NPS score was >3, patients were administered a predetermined dose of nefopam. The dose was calculated using the up-and-down allocation technique based on the previous response. The initial dose was 28 mg, with adjustment intervals of 5 mg. An effective response was defined as a decrease in the NPS score to <3 at 30 minutes after infusion. Results: The ED50 of nefopam was 62.1 mg (95{\%} confidence interval, 52.9–72.9 mg). Eight patients reported pain upon injection, and three were excluded due to severe injection pain and phlebitis. Conclusions: The estimated ED50 was higher than the predetermined dose based on previous studies. We recommend that the dose of nefopam be chosen after careful consideration of individual variations and clinical settings.",
keywords = "cholecystectomy, median effective dose, Nefopam, numerical pain scale, pain, postoperative",
author = "Heezoo Kim and Lee, {Dong Kyu} and Lee, {Mi Kyoung} and Mido Lee",
year = "2018",
month = "9",
day = "1",
doi = "10.1177/0300060518777411",
language = "English",
volume = "46",
pages = "3684--3691",
journal = "Journal of International Medical Research",
issn = "0300-0605",
publisher = "Field House Publishing LLP",
number = "9",

}

TY - JOUR

T1 - Median effective dose of nefopam to treat postoperative pain in patients who have undergone laparoscopic cholecystectomy

AU - Kim, Heezoo

AU - Lee, Dong Kyu

AU - Lee, Mi Kyoung

AU - Lee, Mido

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Objective: Nefopam is thought to reduce postoperative pain; however, the evidence is insufficient. The recommended dose is 20 mg, and the median effective dose (ED50) in the surgical setting reportedly ranges from 17 to 28 mg. However, nefopam frequently produces inadequate postoperative analgesia. We evaluated the ED50 of nefopam as a single agent in patients undergoing laparoscopic cholecystectomy. Methods: Twenty-nine patients were scheduled for laparoscopic cholecystectomy. Postoperative pain was evaluated using a numerical pain scale (NPS). When the NPS score was >3, patients were administered a predetermined dose of nefopam. The dose was calculated using the up-and-down allocation technique based on the previous response. The initial dose was 28 mg, with adjustment intervals of 5 mg. An effective response was defined as a decrease in the NPS score to <3 at 30 minutes after infusion. Results: The ED50 of nefopam was 62.1 mg (95% confidence interval, 52.9–72.9 mg). Eight patients reported pain upon injection, and three were excluded due to severe injection pain and phlebitis. Conclusions: The estimated ED50 was higher than the predetermined dose based on previous studies. We recommend that the dose of nefopam be chosen after careful consideration of individual variations and clinical settings.

AB - Objective: Nefopam is thought to reduce postoperative pain; however, the evidence is insufficient. The recommended dose is 20 mg, and the median effective dose (ED50) in the surgical setting reportedly ranges from 17 to 28 mg. However, nefopam frequently produces inadequate postoperative analgesia. We evaluated the ED50 of nefopam as a single agent in patients undergoing laparoscopic cholecystectomy. Methods: Twenty-nine patients were scheduled for laparoscopic cholecystectomy. Postoperative pain was evaluated using a numerical pain scale (NPS). When the NPS score was >3, patients were administered a predetermined dose of nefopam. The dose was calculated using the up-and-down allocation technique based on the previous response. The initial dose was 28 mg, with adjustment intervals of 5 mg. An effective response was defined as a decrease in the NPS score to <3 at 30 minutes after infusion. Results: The ED50 of nefopam was 62.1 mg (95% confidence interval, 52.9–72.9 mg). Eight patients reported pain upon injection, and three were excluded due to severe injection pain and phlebitis. Conclusions: The estimated ED50 was higher than the predetermined dose based on previous studies. We recommend that the dose of nefopam be chosen after careful consideration of individual variations and clinical settings.

KW - cholecystectomy

KW - median effective dose

KW - Nefopam

KW - numerical pain scale

KW - pain

KW - postoperative

UR - http://www.scopus.com/inward/record.url?scp=85053678399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053678399&partnerID=8YFLogxK

U2 - 10.1177/0300060518777411

DO - 10.1177/0300060518777411

M3 - Article

C2 - 29848156

AN - SCOPUS:85053678399

VL - 46

SP - 3684

EP - 3691

JO - Journal of International Medical Research

JF - Journal of International Medical Research

SN - 0300-0605

IS - 9

ER -