Mediating effects of exercise capacity on the association between physical activity and health-related quality of life among adolescents with complex congenital heart disease

Hyun Jeong Kim, Sae Young Jae, Jina Choo, Ja Kyoung Yoon, Seong Ho Kim, Karsten Königstein, Arno Schmidt-Trucksäss, Barry A. Franklin

Research output: Contribution to journalArticle

Abstract

Objectives: There is little evidence on interrelationships between physical activity, sedentary behaviors, and health-related quality of life (HRQOL) among adolescents with congenital heart disease (CHD). We hypothesized that exercise capacity would have a mediating effect on the associations of either physical activity or sedentary behavior with HRQOL. Methods: Adolescents with complex CHD (n = 111) were consecutively recruited from an outpatient clinic in a general hospital in South Korea. Physical activity and sedentary behavior were assessed using the global physical activity questionnaire. Exercise capacity was directly measured by peak oxygen uptake using a symptom-limited maximal treadmill exercise test. HRQOL was evaluated by both adolescents and their parents using the Pediatric Quality of Life Inventory questionnaire. Results: The self-reported and parent proxy-reported HRQOL were positively associated with physical activity (ß = 0.16, P =.003; ß = 0.12, P =.049) and exercise capacity (ß = 0.63, P <.001; ß = 0.66, P <.001), but not with sedentary behavior in adjusted regression models. When both variables were entered in the same regression models, only exercise capacity remained significantly associated with the self-reported (ß = 0.50, P =.008) and parent proxy-reported HRQOL (ß = 0.62, P =.003). Exercise capacity acted as a full mediator variable on the relationship between physical activity and HRQOL (P <.05 for both). Conclusions: The present findings suggest that exercise capacity mediates the association between physical activity and HRQOL, highlighting the importance of improving exercise capacity to potentially enhance HRQOL in adolescents with complex CHD.

Original languageEnglish
Article numbere23297
JournalAmerican Journal of Human Biology
DOIs
Publication statusPublished - 2019 Jan 1

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physical activity
cardiovascular disease
heart diseases
heart disease
quality of life
Heart Diseases
exercise
Quality of Life
Exercise
adolescent
health
parents
questionnaires
Proxy
effect
Exercise Test
regression
outpatient clinic
exercise test
questionnaire

ASJC Scopus subject areas

  • Anatomy
  • Ecology, Evolution, Behavior and Systematics
  • Anthropology
  • Genetics

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Mediating effects of exercise capacity on the association between physical activity and health-related quality of life among adolescents with complex congenital heart disease. / Kim, Hyun Jeong; Jae, Sae Young; Choo, Jina; Yoon, Ja Kyoung; Kim, Seong Ho; Königstein, Karsten; Schmidt-Trucksäss, Arno; Franklin, Barry A.

In: American Journal of Human Biology, 01.01.2019.

Research output: Contribution to journalArticle

Kim, Hyun Jeong ; Jae, Sae Young ; Choo, Jina ; Yoon, Ja Kyoung ; Kim, Seong Ho ; Königstein, Karsten ; Schmidt-Trucksäss, Arno ; Franklin, Barry A. / Mediating effects of exercise capacity on the association between physical activity and health-related quality of life among adolescents with complex congenital heart disease. In: American Journal of Human Biology. 2019.
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AU - Yoon, Ja Kyoung

AU - Kim, Seong Ho

AU - Königstein, Karsten

AU - Schmidt-Trucksäss, Arno

AU - Franklin, Barry A.

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