Mediation analysis of triple networks revealed functional feature of mindfulness from real-time fMRI neurofeedback

Hyun Chul Kim, Marion Tegethoff, Gunther Meinlschmidt, Esther Stalujanis, Angelo Belardi, Sungman Jo, Juhyeon Lee, Dong Youl Kim, Seung Schik Yoo, Jong-Hwan Lee

Research output: Contribution to journalArticle

Abstract

The triple networks, namely the default-mode network (DMN), the central executive network (CEN), and the salience network (SN), play crucial roles in disorders of the brain, as well as in basic neuroscientific processes such as mindfulness. However, currently, there is no consensus on the underlying functional features of the triple networks associated with mindfulness. In this study, we tested the hypothesis that (a) the partial regression coefficient (i.e., slope): from the SN to the DMN, mediated by the CEN, would be one of the potential mindfulness features in the real-time functional magnetic resonance imaging (rtfMRI) neurofeedback (NF) setting, and (b) this slope level may be enhanced by rtfMRI-NF training. Sixty healthy mindfulness-naïve males participated in an MRI session consisting of two non-rtfMRI-runs, followed by two rtfMRI-NF runs and one transfer run. Once the regions-of-interest of each of the triple networks were defined using the non-rtfMRI-runs, the slope level was calculated by mediation analysis and used as neurofeedback information, in the form of a thermometer bar, to assist with participant mindfulness during the rtfMRI-NF runs. The participants were asked to increase the level of the thermometer bar while deploying a mindfulness strategy, which consisted of focusing attention on the physical sensations of breathing. rtfMRI-NF training was conducted as part of a randomized controlled trial design, in which participants were randomly assigned to either an experimental group or a control group. The participants in the experimental group received contingent neurofeedback information, which was obtained from their own brain signals, whereas the participants in the control group received non-contingent neurofeedback information that originated from matched participants in the experimental group. Our results indicated that the slope level from the SN to the DMN, mediated by the CEN, was associated with mindfulness score (rtfMRI-NF runs: r = 0.53, p = 0.007; p-value was corrected from 10,000 random permutations) and with task-performance feedback score (rtfMRI-NF run: r = 0.61, p = 0.001) in the experimental group only. In addition, during the rtfMRI-NF runs the level of the partial regression coefficient feature was substantially increased in the experimental group compared to the control group (p < 0.05 from the paired t-test; the p-value was corrected from 10,000 random permutations). To the best of our knowledge, this is the first study to demonstrate a partial regression coefficient feature of mindfulness in the rtfMRI-NF setting obtained by triple network mediation analysis, as well as the possibility of enhancement of the partial regression coefficient feature by rtfMRI-NF training.

Original languageEnglish
Pages (from-to)409-432
Number of pages24
JournalNeuroImage
Volume195
DOIs
Publication statusPublished - 2019 Jul 15

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Neurofeedback
Mindfulness
Magnetic Resonance Imaging
Thermometers
Control Groups
Task Performance and Analysis
Brain Diseases

Keywords

  • Central executive network
  • Contemplative science
  • Default-mode network
  • Functional connectivity
  • Functional magnetic resonance imaging
  • Mediation analysis
  • Mindfulness
  • Real-time fMRI neurofeedback
  • Salience network

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Mediation analysis of triple networks revealed functional feature of mindfulness from real-time fMRI neurofeedback. / Kim, Hyun Chul; Tegethoff, Marion; Meinlschmidt, Gunther; Stalujanis, Esther; Belardi, Angelo; Jo, Sungman; Lee, Juhyeon; Kim, Dong Youl; Yoo, Seung Schik; Lee, Jong-Hwan.

In: NeuroImage, Vol. 195, 15.07.2019, p. 409-432.

Research output: Contribution to journalArticle

Kim, HC, Tegethoff, M, Meinlschmidt, G, Stalujanis, E, Belardi, A, Jo, S, Lee, J, Kim, DY, Yoo, SS & Lee, J-H 2019, 'Mediation analysis of triple networks revealed functional feature of mindfulness from real-time fMRI neurofeedback', NeuroImage, vol. 195, pp. 409-432. https://doi.org/10.1016/j.neuroimage.2019.03.066
Kim, Hyun Chul ; Tegethoff, Marion ; Meinlschmidt, Gunther ; Stalujanis, Esther ; Belardi, Angelo ; Jo, Sungman ; Lee, Juhyeon ; Kim, Dong Youl ; Yoo, Seung Schik ; Lee, Jong-Hwan. / Mediation analysis of triple networks revealed functional feature of mindfulness from real-time fMRI neurofeedback. In: NeuroImage. 2019 ; Vol. 195. pp. 409-432.
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AU - Stalujanis, Esther

AU - Belardi, Angelo

AU - Jo, Sungman

AU - Lee, Juhyeon

AU - Kim, Dong Youl

AU - Yoo, Seung Schik

AU - Lee, Jong-Hwan

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N2 - The triple networks, namely the default-mode network (DMN), the central executive network (CEN), and the salience network (SN), play crucial roles in disorders of the brain, as well as in basic neuroscientific processes such as mindfulness. However, currently, there is no consensus on the underlying functional features of the triple networks associated with mindfulness. In this study, we tested the hypothesis that (a) the partial regression coefficient (i.e., slope): from the SN to the DMN, mediated by the CEN, would be one of the potential mindfulness features in the real-time functional magnetic resonance imaging (rtfMRI) neurofeedback (NF) setting, and (b) this slope level may be enhanced by rtfMRI-NF training. Sixty healthy mindfulness-naïve males participated in an MRI session consisting of two non-rtfMRI-runs, followed by two rtfMRI-NF runs and one transfer run. Once the regions-of-interest of each of the triple networks were defined using the non-rtfMRI-runs, the slope level was calculated by mediation analysis and used as neurofeedback information, in the form of a thermometer bar, to assist with participant mindfulness during the rtfMRI-NF runs. The participants were asked to increase the level of the thermometer bar while deploying a mindfulness strategy, which consisted of focusing attention on the physical sensations of breathing. rtfMRI-NF training was conducted as part of a randomized controlled trial design, in which participants were randomly assigned to either an experimental group or a control group. The participants in the experimental group received contingent neurofeedback information, which was obtained from their own brain signals, whereas the participants in the control group received non-contingent neurofeedback information that originated from matched participants in the experimental group. Our results indicated that the slope level from the SN to the DMN, mediated by the CEN, was associated with mindfulness score (rtfMRI-NF runs: r = 0.53, p = 0.007; p-value was corrected from 10,000 random permutations) and with task-performance feedback score (rtfMRI-NF run: r = 0.61, p = 0.001) in the experimental group only. In addition, during the rtfMRI-NF runs the level of the partial regression coefficient feature was substantially increased in the experimental group compared to the control group (p < 0.05 from the paired t-test; the p-value was corrected from 10,000 random permutations). To the best of our knowledge, this is the first study to demonstrate a partial regression coefficient feature of mindfulness in the rtfMRI-NF setting obtained by triple network mediation analysis, as well as the possibility of enhancement of the partial regression coefficient feature by rtfMRI-NF training.

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