Medication event monitoring system for infectious tuberculosis treatment in Morocco: A retrospective cohort study

Seup Park, Ilham Sentissi, Seung Jae Gil, Won Seok Park, Byung Kwon Oh, Ah Reum Son, Young Ju Kong, Sol Park, Eunseong Paek, Yong Joon Park, Seung Heon Lee

Research output: Contribution to journalArticle


Non-adherence to tuberculosis (TB) treatment is a barrier to effective TB control. We investigated the effectiveness of a Medication Event Monitoring System (MEMS) as a tailored adherence-promoting intervention in Morocco. We compared patients who received a MEMS (n = 206) with patients who received standard TB care (n = 141) among new active TB patients with sputum smear-positive. The mean total medication days were 141.87 ± 29.5 in the control group and 140.85 ± 17.9 in the MEMS group (p = 0.7147), and the mean age and sex were not different between the two groups (p > 0.05). The treatment success rate was significantly higher in the MEMS group than in the control group (odds ratio (OR): 4.33, 95% confidence interval (CI): 2.13-8.81, p < 0.001), and the lost to follow-up rate was significantly lower in the MEMS group than in the control group (OR: 0.03, 95% CI: 0.05-0.24, p < 0.001) after adjusting for sex, age, and health centers. The mean drug adherence rate in the first month was significantly higher in the MEMS group than in the control group (p = 0.023). MEMS increased TB treatment success rate and decreased the lost to follow-up rate overall for infectious TB patients in a Moroccan rural area.

Original languageEnglish
Article number412
JournalInternational journal of environmental research and public health
Issue number3
Publication statusPublished - 2019 Jan 1



  • Lost to follow-up rate
  • Medication event monitoring system
  • Morocco
  • Success rate
  • Tuberculosis

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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