Medication event monitoring system for infectious tuberculosis treatment in Morocco: A retrospective cohort study

Seup Park, Ilham Sentissi, Seung Jae Gil, Won Seok Park, Byung Kwon Oh, Ah Reum Son, Young Ju Kong, Sol Park, Eunseong Paek, Yong Joon Park, Seung Heon Lee

Research output: Contribution to journalArticle

Abstract

Non-adherence to tuberculosis (TB) treatment is a barrier to effective TB control. We investigated the effectiveness of a Medication Event Monitoring System (MEMS) as a tailored adherence-promoting intervention in Morocco. We compared patients who received a MEMS (n = 206) with patients who received standard TB care (n = 141) among new active TB patients with sputum smear-positive. The mean total medication days were 141.87 ± 29.5 in the control group and 140.85 ± 17.9 in the MEMS group (p = 0.7147), and the mean age and sex were not different between the two groups (p > 0.05). The treatment success rate was significantly higher in the MEMS group than in the control group (odds ratio (OR): 4.33, 95% confidence interval (CI): 2.13-8.81, p < 0.001), and the lost to follow-up rate was significantly lower in the MEMS group than in the control group (OR: 0.03, 95% CI: 0.05-0.24, p < 0.001) after adjusting for sex, age, and health centers. The mean drug adherence rate in the first month was significantly higher in the MEMS group than in the control group (p = 0.023). MEMS increased TB treatment success rate and decreased the lost to follow-up rate overall for infectious TB patients in a Moroccan rural area.

Original languageEnglish
Article number412
JournalInternational journal of environmental research and public health
Volume16
Issue number3
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Morocco
Tuberculosis
Cohort Studies
Retrospective Studies
Control Groups
Lost to Follow-Up
Therapeutics
Odds Ratio
Confidence Intervals
Sputum
Health
Pharmaceutical Preparations

Keywords

  • Lost to follow-up rate
  • Medication event monitoring system
  • Morocco
  • Success rate
  • Tuberculosis

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Medication event monitoring system for infectious tuberculosis treatment in Morocco : A retrospective cohort study. / Park, Seup; Sentissi, Ilham; Gil, Seung Jae; Park, Won Seok; Oh, Byung Kwon; Son, Ah Reum; Kong, Young Ju; Park, Sol; Paek, Eunseong; Park, Yong Joon; Lee, Seung Heon.

In: International journal of environmental research and public health, Vol. 16, No. 3, 412, 01.01.2019.

Research output: Contribution to journalArticle

Park, Seup ; Sentissi, Ilham ; Gil, Seung Jae ; Park, Won Seok ; Oh, Byung Kwon ; Son, Ah Reum ; Kong, Young Ju ; Park, Sol ; Paek, Eunseong ; Park, Yong Joon ; Lee, Seung Heon. / Medication event monitoring system for infectious tuberculosis treatment in Morocco : A retrospective cohort study. In: International journal of environmental research and public health. 2019 ; Vol. 16, No. 3.
@article{82884ff0500342c8b691bbdad9144c18,
title = "Medication event monitoring system for infectious tuberculosis treatment in Morocco: A retrospective cohort study",
abstract = "Non-adherence to tuberculosis (TB) treatment is a barrier to effective TB control. We investigated the effectiveness of a Medication Event Monitoring System (MEMS) as a tailored adherence-promoting intervention in Morocco. We compared patients who received a MEMS (n = 206) with patients who received standard TB care (n = 141) among new active TB patients with sputum smear-positive. The mean total medication days were 141.87 ± 29.5 in the control group and 140.85 ± 17.9 in the MEMS group (p = 0.7147), and the mean age and sex were not different between the two groups (p > 0.05). The treatment success rate was significantly higher in the MEMS group than in the control group (odds ratio (OR): 4.33, 95{\%} confidence interval (CI): 2.13-8.81, p < 0.001), and the lost to follow-up rate was significantly lower in the MEMS group than in the control group (OR: 0.03, 95{\%} CI: 0.05-0.24, p < 0.001) after adjusting for sex, age, and health centers. The mean drug adherence rate in the first month was significantly higher in the MEMS group than in the control group (p = 0.023). MEMS increased TB treatment success rate and decreased the lost to follow-up rate overall for infectious TB patients in a Moroccan rural area.",
keywords = "Lost to follow-up rate, Medication event monitoring system, Morocco, Success rate, Tuberculosis",
author = "Seup Park and Ilham Sentissi and Gil, {Seung Jae} and Park, {Won Seok} and Oh, {Byung Kwon} and Son, {Ah Reum} and Kong, {Young Ju} and Sol Park and Eunseong Paek and Park, {Yong Joon} and Lee, {Seung Heon}",
year = "2019",
month = "1",
day = "1",
doi = "10.3390/ijerph16030412",
language = "English",
volume = "16",
journal = "International Journal of Environmental Research and Public Health",
issn = "1661-7827",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

TY - JOUR

T1 - Medication event monitoring system for infectious tuberculosis treatment in Morocco

T2 - A retrospective cohort study

AU - Park, Seup

AU - Sentissi, Ilham

AU - Gil, Seung Jae

AU - Park, Won Seok

AU - Oh, Byung Kwon

AU - Son, Ah Reum

AU - Kong, Young Ju

AU - Park, Sol

AU - Paek, Eunseong

AU - Park, Yong Joon

AU - Lee, Seung Heon

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Non-adherence to tuberculosis (TB) treatment is a barrier to effective TB control. We investigated the effectiveness of a Medication Event Monitoring System (MEMS) as a tailored adherence-promoting intervention in Morocco. We compared patients who received a MEMS (n = 206) with patients who received standard TB care (n = 141) among new active TB patients with sputum smear-positive. The mean total medication days were 141.87 ± 29.5 in the control group and 140.85 ± 17.9 in the MEMS group (p = 0.7147), and the mean age and sex were not different between the two groups (p > 0.05). The treatment success rate was significantly higher in the MEMS group than in the control group (odds ratio (OR): 4.33, 95% confidence interval (CI): 2.13-8.81, p < 0.001), and the lost to follow-up rate was significantly lower in the MEMS group than in the control group (OR: 0.03, 95% CI: 0.05-0.24, p < 0.001) after adjusting for sex, age, and health centers. The mean drug adherence rate in the first month was significantly higher in the MEMS group than in the control group (p = 0.023). MEMS increased TB treatment success rate and decreased the lost to follow-up rate overall for infectious TB patients in a Moroccan rural area.

AB - Non-adherence to tuberculosis (TB) treatment is a barrier to effective TB control. We investigated the effectiveness of a Medication Event Monitoring System (MEMS) as a tailored adherence-promoting intervention in Morocco. We compared patients who received a MEMS (n = 206) with patients who received standard TB care (n = 141) among new active TB patients with sputum smear-positive. The mean total medication days were 141.87 ± 29.5 in the control group and 140.85 ± 17.9 in the MEMS group (p = 0.7147), and the mean age and sex were not different between the two groups (p > 0.05). The treatment success rate was significantly higher in the MEMS group than in the control group (odds ratio (OR): 4.33, 95% confidence interval (CI): 2.13-8.81, p < 0.001), and the lost to follow-up rate was significantly lower in the MEMS group than in the control group (OR: 0.03, 95% CI: 0.05-0.24, p < 0.001) after adjusting for sex, age, and health centers. The mean drug adherence rate in the first month was significantly higher in the MEMS group than in the control group (p = 0.023). MEMS increased TB treatment success rate and decreased the lost to follow-up rate overall for infectious TB patients in a Moroccan rural area.

KW - Lost to follow-up rate

KW - Medication event monitoring system

KW - Morocco

KW - Success rate

KW - Tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=85060926030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060926030&partnerID=8YFLogxK

U2 - 10.3390/ijerph16030412

DO - 10.3390/ijerph16030412

M3 - Article

C2 - 30709029

AN - SCOPUS:85060926030

VL - 16

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

SN - 1661-7827

IS - 3

M1 - 412

ER -