Melampolides from the leaves of Smallanthus sonchifolius and their inhibitory activity of LPS-induced nitric oxide production

Seong Su Hong, Seon A. Lee, Xiang Hua Han, Min Hee Lee, Ji Sang Hwang, Jeong Sook Park, Ki Wan Oh, Kun Han, Myung Koo Lee, Heesoon Lee, Wook Kim, Dongho Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Two new melampolide-type sesquiterpene lactones, 8β-epoxyangeloyloxy- 9α-ethoxy-14-oxo-acanthospermolide (1) and 8β-angeloyloxy-9α- ethoxy-14-oxo-acanthospermolide (2), were isolated from the leaves of yacon [Smallanthus sonchifolia (POEPP. et ENDL.) H. Robinson] along with eleven known melampolides, allo-schkuhriolide (3), enhydrin (4), polymatin A (5), fluctuanin (6), 8β-angeloyloxy-9α-acetoxy-14-oxo-acanthospermolide (7), 8β-angeloyloxy-14-oxo-acanthospermolide (8), 8β- methacryloyloxymelampolid-14-oic acid methyl ester (9), uvedalin (10), polymatin B (11), 8β-tigloyloxymelampolid-14-oic acid methyl ester (12), and sonchifolin (13). Their structures were established on the basis of spectroscopic evidence including 1D- and 2D-NMR experiments. All isolates were evaluated for inhibition of LPS-induced nitric oxide production in murine macrophage RAW 264.7 cells.

Original languageEnglish
Pages (from-to)199-202
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume56
Issue number2
DOIs
Publication statusPublished - 2008 Feb 1

    Fingerprint

Keywords

  • Asteraceae
  • Melampolide
  • Nitric oxide production inhibitor
  • Sesquiterpene lactone
  • Smallanthus sonchifolius
  • Yacon

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Hong, S. S., Lee, S. A., Han, X. H., Lee, M. H., Hwang, J. S., Park, J. S., Oh, K. W., Han, K., Lee, M. K., Lee, H., Kim, W., Lee, D., & Hwang, B. Y. (2008). Melampolides from the leaves of Smallanthus sonchifolius and their inhibitory activity of LPS-induced nitric oxide production. Chemical and Pharmaceutical Bulletin, 56(2), 199-202. https://doi.org/10.1248/cpb.56.199