Melanogenesis inhibitory daphnane diterpenoids from the flower buds of Daphne genkwa

Kwon Ki Bang, Cheong Yong Yun, Chul Lee, Qinghao Jin, Jin Woo Lee, Sang Hun Jung, Dongho Lee, Mi Kyeong Lee, Jin Tae Hong, Youngsoo Kim, Bang Yeon Hwang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Two new daphnane-type diterpene esters, daphneresiniferins A (1) and B (2), along with seven known diterpenes, yuanhuacine (3), yuanhuadine (4), yuanhuahine (5), genkwadaphnin (6), genkwanine A (7), genkwanine F (8), and genkwanine H (9), were isolated from the methanol extract of the flower buds of Daphne genkwa. Their structures were elucidated on the basis of spectroscopic methods, especially 2D NMR spectra such as HMQC, HMBC, and NOESY. All the isolates were evaluated for their inhibitory effects of the melanogenesis against α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells.

Original languageEnglish
Pages (from-to)3334-3337
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number11
DOIs
Publication statusPublished - 2013 Jun 1

Keywords

  • Daphnane-type diterpene
  • Daphne genkwa
  • Melanogenesis inhibitor
  • Thymelaeaceae

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Bang, K. K., Yun, C. Y., Lee, C., Jin, Q., Lee, J. W., Jung, S. H., Lee, D., Lee, M. K., Hong, J. T., Kim, Y., & Hwang, B. Y. (2013). Melanogenesis inhibitory daphnane diterpenoids from the flower buds of Daphne genkwa. Bioorganic and Medicinal Chemistry Letters, 23(11), 3334-3337. https://doi.org/10.1016/j.bmcl.2013.03.096