Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum

Qinghao Jin, Xiang Hua Han, Cheong Yong Yun, Chul Lee, Jin Woo Lee, Dongho Lee, Mi Kyeong Lee, Sang Hun Jung, Jin Tae Hong, Youngsoo Kim, Bang Yeon Hwang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the methanolic extract from the roots of Cynanchum atratum has resulted in the isolation of three new pregnane glycosides (1-3) along with four known compounds (4-7). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for their potential to inhibit the melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells. Of these, compounds 4-7 dose-dependently inhibited the melanin production with the IC50 values ranging from 4 μM to 33 μM.

Original languageEnglish
JournalBioorganic and Medicinal Chemistry Letters
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Fingerprint

Melanins
Melanocyte-Stimulating Hormones
Experimental Melanomas
Bioassay
Fractionation
Biological Assay
Inhibitory Concentration 50
Nuclear magnetic resonance
Vincetoxicum
pregnane glycoside

Keywords

  • Asclepiadaceae
  • Cynanchum atratum
  • Melanogenesis inhibitor
  • Pregnane glycosides
  • α-MSH

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum. / Jin, Qinghao; Han, Xiang Hua; Yun, Cheong Yong; Lee, Chul; Lee, Jin Woo; Lee, Dongho; Lee, Mi Kyeong; Jung, Sang Hun; Hong, Jin Tae; Kim, Youngsoo; Hwang, Bang Yeon.

In: Bioorganic and Medicinal Chemistry Letters, 01.01.2018.

Research output: Contribution to journalArticle

Jin, Qinghao ; Han, Xiang Hua ; Yun, Cheong Yong ; Lee, Chul ; Lee, Jin Woo ; Lee, Dongho ; Lee, Mi Kyeong ; Jung, Sang Hun ; Hong, Jin Tae ; Kim, Youngsoo ; Hwang, Bang Yeon. / Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum. In: Bioorganic and Medicinal Chemistry Letters. 2018.
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AU - Yun, Cheong Yong

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AU - Lee, Dongho

AU - Lee, Mi Kyeong

AU - Jung, Sang Hun

AU - Hong, Jin Tae

AU - Kim, Youngsoo

AU - Hwang, Bang Yeon

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