Membrane-delimited coupling of TRPV1 and mGluR5 on presynaptic terminals of nociceptive neurons

Ho Kim Yong, Chul Kyu Park, Keun Back Seung, C. Justin Lee, Jin Hwang Se, Chul Bae Yong, Sik Na Heung, Soo Kim Joong, Jun Jung Sung, Bae Oh Seog

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Abstract

Transient receptor potential vanilloid subtype 1 (TRPV1) and metabotropic glutamate receptor 5 (mGluR5) located on peripheral sensory terminals have been shown to play critical roles in the transduction and modulation of pain sensation. To date, however, very little is known regarding the significance of functional expression of mGluR5 and TRPV1 on the central terminals of sensory neurons in the dorsal horn of the spinal cord. Here we show that TRPV1 on central presynaptic terminals is coupled to mGluR5 in a membranedelimited manner, thereby contributing to the modulation of nociceptive synaptic transmission in the substantia gelatinosa neurons of the spinal cord. Further, our results demonstrate that TRPV1 is involved in the pain behaviors induced by spinal mGluR5 activation, and diacylglycerol produced by the activation of mGluR5 mediates functional coupling of mGluR5 and TRPV1 on the presynaptic terminals. Thus, mGluR5-TRPV1 coupling on the central presynaptic terminals of nociceptive neurons may be an important mechanism underlying central sensitization under pathological pain conditions.

Original languageEnglish
Pages (from-to)10000-10009
Number of pages10
JournalJournal of Neuroscience
Volume29
Issue number32
DOIs
Publication statusPublished - 2009 Aug 12

ASJC Scopus subject areas

  • Neuroscience(all)

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    Yong, H. K., Park, C. K., Seung, K. B., Lee, C. J., Se, J. H., Yong, C. B., Heung, S. N., Joong, S. K., Sung, J. J., & Seog, B. O. (2009). Membrane-delimited coupling of TRPV1 and mGluR5 on presynaptic terminals of nociceptive neurons. Journal of Neuroscience, 29(32), 10000-10009. https://doi.org/10.1523/JNEUROSCI.5030-08.2009