Membranous nephropathy in a 13-year-old boy with common variable immunodeficiency

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Various forms of hypogammaglobulinemia can occur in patients with autoimmune diseases and vice versa. We report a 13-yr-old boy with membranous nephropathy and common variable immunodeficiency. He presented with the nephrotic syndrome, pneumonia with bronchiectasis, and profound hypogammaglobulinemia. Renal biopsy showed diffusely thickened glomerular capillary walls with 'spikes' suggesting a membranous nephropathy. Secondary causes were ruled out by laboratory studies;however, heavy proteinuria persisted with steroid therapy. Cyclosporine and intravenous immunoglobulin were added, and the patient was discharged with decreased proteinuria. Hypogammaglobulinemia may have a deleterious impact on the immune dysregulation in some patients with membranous nephropathy.

Original languageEnglish
Pages (from-to)1436-1438
Number of pages3
JournalJournal of Korean Medical Science
Volume27
Issue number11
DOIs
Publication statusPublished - 2012 Dec 1

Fingerprint

Common Variable Immunodeficiency
Agammaglobulinemia
Membranous Glomerulonephritis
Proteinuria
Bronchiectasis
Intravenous Immunoglobulins
Nephrotic Syndrome
Cyclosporine
Autoimmune Diseases
Pneumonia
Steroids
Kidney
Biopsy
Therapeutics

Keywords

  • Autoimmunity
  • Common variable immunodeficiency
  • Immunoglobulins
  • Membranous glomerulonephritis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Membranous nephropathy in a 13-year-old boy with common variable immunodeficiency. / Yim, Hyung-Eun; Yoo, Kee Hwan.

In: Journal of Korean Medical Science, Vol. 27, No. 11, 01.12.2012, p. 1436-1438.

Research output: Contribution to journalArticle

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