Membranous nephropathy in a 13-year-old boy with common variable immunodeficiency

Hyung Eun Yim, Kee Hwan Yoo

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)


    Various forms of hypogammaglobulinemia can occur in patients with autoimmune diseases and vice versa. We report a 13-yr-old boy with membranous nephropathy and common variable immunodeficiency. He presented with the nephrotic syndrome, pneumonia with bronchiectasis, and profound hypogammaglobulinemia. Renal biopsy showed diffusely thickened glomerular capillary walls with 'spikes' suggesting a membranous nephropathy. Secondary causes were ruled out by laboratory studies;however, heavy proteinuria persisted with steroid therapy. Cyclosporine and intravenous immunoglobulin were added, and the patient was discharged with decreased proteinuria. Hypogammaglobulinemia may have a deleterious impact on the immune dysregulation in some patients with membranous nephropathy.

    Original languageEnglish
    Pages (from-to)1436-1438
    Number of pages3
    JournalJournal of Korean medical science
    Issue number11
    Publication statusPublished - 2012


    • Autoimmunity
    • Common variable immunodeficiency
    • Immunoglobulins
    • Membranous glomerulonephritis

    ASJC Scopus subject areas

    • Medicine(all)


    Dive into the research topics of 'Membranous nephropathy in a 13-year-old boy with common variable immunodeficiency'. Together they form a unique fingerprint.

    Cite this