Meniscectomy alters the dynamic deformational behavior and cumulative strain of tibial articular cartilage in knee joints subjected to cyclic loads

Yongnam Song, J. M. Greve, D. R. Carter, N. J. Giori

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Objective: Meniscectomy-induced osteoarthritis may be mechanically based. We asked how meniscectomy alters time-dependent deformation of physiologically loaded articular cartilage. We hypothesized that meniscectomy alters nominal strain in tibial articular cartilage, and that meniscectomy affects cartilage thickness recovery following cessation of loading. Methods: A cyclic load simulating normal gait was applied to four sheep knees. A custom device was used to obtain MR images of cartilage at 4.7 T during cyclic loading. Articular cartilage thickness and nominal strain were measured every 2.5 min during 1 h of cyclic loading, and during 2.5 h after cessation of loading. Results: Following meniscectomy the loaded joints rapidly developed high strain centrally and minimal strain peripherally. Maximum nominal strains after 1 h of loading were about 55% in the intact knees and 72% in the meniscectomized knees. Nominal strains in the peripheral tibial cartilage were significantly reduced in the meniscectomized knees. Strain recovery was markedly prolonged in the meniscectomized knees. Conclusions: With meniscectomy, tibial articular cartilage in the central load bearing region remains chronically deformed and dehydrated, even after cessation of loading. Post-meniscectomy osteoarthritis may be initiated in this region by direct damage to the cartilage matrix, or by altering the hydration of the tissue. In peripheral regions, reduced loading and strain may facilitate subchondral vascular invasion, and endochondral ossification. This is consistent with the central fibrillation and peripheral osteophyte formation seen in post-meniscectomy osteoarthritis.

Original languageEnglish
Pages (from-to)1545-1554
Number of pages10
JournalOsteoarthritis and Cartilage
Volume16
Issue number12
DOIs
Publication statusPublished - 2008 Dec 1
Externally publishedYes

Fingerprint

Cyclic loads
Cartilage
Articular Cartilage
Knee Joint
Knee
Osteoarthritis
Osteophyte
Weight-Bearing
Bearings (structural)
Gait
Osteogenesis
Blood Vessels
Sheep
Recovery
Joints
Equipment and Supplies
Hydration
Tissue

Keywords

  • Articular cartilage
  • Cyclic loading
  • Dynamic MR imaging
  • Meniscectomy
  • Osteoarthritis
  • Time-dependent deformation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Orthopedics and Sports Medicine
  • Rheumatology

Cite this

Meniscectomy alters the dynamic deformational behavior and cumulative strain of tibial articular cartilage in knee joints subjected to cyclic loads. / Song, Yongnam; Greve, J. M.; Carter, D. R.; Giori, N. J.

In: Osteoarthritis and Cartilage, Vol. 16, No. 12, 01.12.2008, p. 1545-1554.

Research output: Contribution to journalArticle

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abstract = "Objective: Meniscectomy-induced osteoarthritis may be mechanically based. We asked how meniscectomy alters time-dependent deformation of physiologically loaded articular cartilage. We hypothesized that meniscectomy alters nominal strain in tibial articular cartilage, and that meniscectomy affects cartilage thickness recovery following cessation of loading. Methods: A cyclic load simulating normal gait was applied to four sheep knees. A custom device was used to obtain MR images of cartilage at 4.7 T during cyclic loading. Articular cartilage thickness and nominal strain were measured every 2.5 min during 1 h of cyclic loading, and during 2.5 h after cessation of loading. Results: Following meniscectomy the loaded joints rapidly developed high strain centrally and minimal strain peripherally. Maximum nominal strains after 1 h of loading were about 55{\%} in the intact knees and 72{\%} in the meniscectomized knees. Nominal strains in the peripheral tibial cartilage were significantly reduced in the meniscectomized knees. Strain recovery was markedly prolonged in the meniscectomized knees. Conclusions: With meniscectomy, tibial articular cartilage in the central load bearing region remains chronically deformed and dehydrated, even after cessation of loading. Post-meniscectomy osteoarthritis may be initiated in this region by direct damage to the cartilage matrix, or by altering the hydration of the tissue. In peripheral regions, reduced loading and strain may facilitate subchondral vascular invasion, and endochondral ossification. This is consistent with the central fibrillation and peripheral osteophyte formation seen in post-meniscectomy osteoarthritis.",
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