Mesenchymal stem cells for enhancing biological healing after meniscal injuries

Hye Chang Rhim, Ok Hee Jeon, Seung Beom Han, Ji Hoon Bae, Dong Won Suh, Ki Mo Jang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The meniscus is a semilunar fibrocartilage structure that plays important roles in maintaining normal knee biomechanics and function. The roles of the meniscus, including load distribution, force transmission, shock absorption, joint stability, lubrication, and proprioception, have been well established. Injury to the meniscus can disrupt overall joint stability and cause various symptoms including pain, swelling, giving-way, and locking. Unless treated properly, it can lead to early degeneration of the knee joint. Because meniscal injuries remain a significant challenge due to its low intrinsic healing potential, most notably in avascular and aneural inner two-thirds of the area, more efficient repair methods are needed. Mesenchymal stem cells (MSCs) have been investigated for their therapeutic potential in vitro and in vivo. Thus far, the application of MSCs, including bone marrow-derived, synovium-derived, and adipose-derived MSCs, has shown promising results in preclinical studies in different animal models. These preclinical studies could be categorized into intra-articular injection and tissueengineered construct application according to delivery method. Despite promising results in preclinical studies, there is still a lack of clinical evidence. This review describes the basic knowledge, current treatment, and recent studies regarding the application of MSCs in treating meniscal injuries. Future directions for MSC-based approaches to enhance meniscal healing are suggested

Original languageEnglish
Pages (from-to)1005-1029
Number of pages25
JournalWorld Journal of Stem Cells
Volume13
Issue number8
DOIs
Publication statusPublished - 2021

Keywords

  • Cell-based treatment
  • Meniscus
  • Meniscus healing
  • Mesenchymal stem cell
  • Tissue engineering

ASJC Scopus subject areas

  • Histology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cell Biology

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