Mesocorticolimbic hyperactivity of deprived smokers and brain imaging

Jong-Hwan Lee, Dong Youl Kim, Junghoe Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We determined the association of neuronal circuitry with the desire to smoke by acquiring and analyzing functional MRI data. The data were acquired in both abstained and subsequently satiated (by 'natural' cigarette smoking) heavy smokers and also in demographically and intellectually matched nonsmokers. During the acquisition, participants were viewing alternating smoking and nonsmoking images that were interleaved by fixation images. From the results, the activities in the mesocorticolimbic pathway including the orbitofrontal cortex, parahippocampus, hippocampus, and midbrain were significantly negatively correlated with carbon monoxide (CO) levels. In contrast, the activities in the motor area and the posterior cingulate cortex plus precuneus were significantly positively correlated with the CO levels. This is the first study to show that mesocorticolimbic and midbrain activities are strongly associated with CO levels, and therefore, possibly with smoking desire levels because of the strong correlation between CO levels and blood nicotine levels.

Original languageEnglish
Pages (from-to)1039-1043
Number of pages5
JournalNeuroReport
Volume23
Issue number18
DOIs
Publication statusPublished - 2012 Dec 19

Fingerprint

Carbon Monoxide
Neuroimaging
Smoking
Mesencephalon
Parietal Lobe
Gyrus Cinguli
Motor Cortex
Prefrontal Cortex
Nicotine
Smoke
Hippocampus
Magnetic Resonance Imaging

Keywords

  • Blood oxygenation level-dependent
  • carbon monoxide
  • functional magnetic resonance imaging
  • hippocampus
  • midbrain
  • orbitofrontal cortex
  • smoking cessation
  • smoking craving
  • smoking deprivation
  • smoking desire

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mesocorticolimbic hyperactivity of deprived smokers and brain imaging. / Lee, Jong-Hwan; Kim, Dong Youl; Kim, Junghoe.

In: NeuroReport, Vol. 23, No. 18, 19.12.2012, p. 1039-1043.

Research output: Contribution to journalArticle

Lee, Jong-Hwan ; Kim, Dong Youl ; Kim, Junghoe. / Mesocorticolimbic hyperactivity of deprived smokers and brain imaging. In: NeuroReport. 2012 ; Vol. 23, No. 18. pp. 1039-1043.
@article{d9ecb228162544fea41ce07a7cb57581,
title = "Mesocorticolimbic hyperactivity of deprived smokers and brain imaging",
abstract = "We determined the association of neuronal circuitry with the desire to smoke by acquiring and analyzing functional MRI data. The data were acquired in both abstained and subsequently satiated (by 'natural' cigarette smoking) heavy smokers and also in demographically and intellectually matched nonsmokers. During the acquisition, participants were viewing alternating smoking and nonsmoking images that were interleaved by fixation images. From the results, the activities in the mesocorticolimbic pathway including the orbitofrontal cortex, parahippocampus, hippocampus, and midbrain were significantly negatively correlated with carbon monoxide (CO) levels. In contrast, the activities in the motor area and the posterior cingulate cortex plus precuneus were significantly positively correlated with the CO levels. This is the first study to show that mesocorticolimbic and midbrain activities are strongly associated with CO levels, and therefore, possibly with smoking desire levels because of the strong correlation between CO levels and blood nicotine levels.",
keywords = "Blood oxygenation level-dependent, carbon monoxide, functional magnetic resonance imaging, hippocampus, midbrain, orbitofrontal cortex, smoking cessation, smoking craving, smoking deprivation, smoking desire",
author = "Jong-Hwan Lee and Kim, {Dong Youl} and Junghoe Kim",
year = "2012",
month = "12",
day = "19",
doi = "10.1097/WNR.0b013e32835a98fc",
language = "English",
volume = "23",
pages = "1039--1043",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "18",

}

TY - JOUR

T1 - Mesocorticolimbic hyperactivity of deprived smokers and brain imaging

AU - Lee, Jong-Hwan

AU - Kim, Dong Youl

AU - Kim, Junghoe

PY - 2012/12/19

Y1 - 2012/12/19

N2 - We determined the association of neuronal circuitry with the desire to smoke by acquiring and analyzing functional MRI data. The data were acquired in both abstained and subsequently satiated (by 'natural' cigarette smoking) heavy smokers and also in demographically and intellectually matched nonsmokers. During the acquisition, participants were viewing alternating smoking and nonsmoking images that were interleaved by fixation images. From the results, the activities in the mesocorticolimbic pathway including the orbitofrontal cortex, parahippocampus, hippocampus, and midbrain were significantly negatively correlated with carbon monoxide (CO) levels. In contrast, the activities in the motor area and the posterior cingulate cortex plus precuneus were significantly positively correlated with the CO levels. This is the first study to show that mesocorticolimbic and midbrain activities are strongly associated with CO levels, and therefore, possibly with smoking desire levels because of the strong correlation between CO levels and blood nicotine levels.

AB - We determined the association of neuronal circuitry with the desire to smoke by acquiring and analyzing functional MRI data. The data were acquired in both abstained and subsequently satiated (by 'natural' cigarette smoking) heavy smokers and also in demographically and intellectually matched nonsmokers. During the acquisition, participants were viewing alternating smoking and nonsmoking images that were interleaved by fixation images. From the results, the activities in the mesocorticolimbic pathway including the orbitofrontal cortex, parahippocampus, hippocampus, and midbrain were significantly negatively correlated with carbon monoxide (CO) levels. In contrast, the activities in the motor area and the posterior cingulate cortex plus precuneus were significantly positively correlated with the CO levels. This is the first study to show that mesocorticolimbic and midbrain activities are strongly associated with CO levels, and therefore, possibly with smoking desire levels because of the strong correlation between CO levels and blood nicotine levels.

KW - Blood oxygenation level-dependent

KW - carbon monoxide

KW - functional magnetic resonance imaging

KW - hippocampus

KW - midbrain

KW - orbitofrontal cortex

KW - smoking cessation

KW - smoking craving

KW - smoking deprivation

KW - smoking desire

UR - http://www.scopus.com/inward/record.url?scp=84870247781&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870247781&partnerID=8YFLogxK

U2 - 10.1097/WNR.0b013e32835a98fc

DO - 10.1097/WNR.0b013e32835a98fc

M3 - Article

C2 - 23117137

AN - SCOPUS:84870247781

VL - 23

SP - 1039

EP - 1043

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 18

ER -