Meta-analyses of associations between interleukin-10 polymorphisms and susceptibility to recurrent pregnancy loss

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Abstract

Objective The aim of this study was to investigate whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL). Methods We conducted a literature search using the PubMed and EMBASE databases and performed meta-analyses on the associations between IL-10 -1082 G/A, -819 C/T, and -592 C/A polymorphisms and RPL, using fixed- or random-effects models. Results A total of 15 papers involving 1858 RPL patients and 1949 controls were considered in this study. Meta-analysis of IL-10 -1082 G/A polymorphism revealed no association between RPL and the IL-10 -1082 G allele (OR = 0.999, 95% CI = 0.815-1.223, p = 0.989). However, meta-analysis of IL-10 -819 C/T polymorphism in all study subjects revealed an association between RPL and the IL-10 -819 C allele (OR = 0.680, 95% CI = 0.498-0.927, p = 0.015). Stratification by ethnicity indicated an association between the IL-10 -819 C allele and RPL in the Asian group (OR = 0.421, 95% CI = 0.226-0.783, p = 0.006), but not in the Caucasian and Arab groups (OR = 1.053, 95% CI = 0.218-5.077, p = 0.949, and OR = 0.800, 95% CI = 0.606-1.081, p = 0.152, respectively). Furthermore, a relationship between the IL-10 -592 C allele and RPL was identified in the Asian group (OR = 0.763, 95% CI = 0.633-0.919, p = 0.004), but not in the Caucasian and Arab groups. Conclusions The meta-analyses demonstrate that IL-10 -819 C/T and -592 C/A polymorphisms are associated with RPL susceptibility in Asian women, but not in the Caucasian and Arab populations.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalEuropean Journal of Obstetrics Gynecology and Reproductive Biology
Volume200
DOIs
Publication statusPublished - 2016 May 1

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Interleukin-10
Meta-Analysis
Pregnancy
Alleles
PubMed
Databases
Population

Keywords

  • Interleukin-10
  • Meta-analysis
  • Polymorphism
  • RPL

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

@article{28d40af5efb347209a40674e0e082f57,
title = "Meta-analyses of associations between interleukin-10 polymorphisms and susceptibility to recurrent pregnancy loss",
abstract = "Objective The aim of this study was to investigate whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL). Methods We conducted a literature search using the PubMed and EMBASE databases and performed meta-analyses on the associations between IL-10 -1082 G/A, -819 C/T, and -592 C/A polymorphisms and RPL, using fixed- or random-effects models. Results A total of 15 papers involving 1858 RPL patients and 1949 controls were considered in this study. Meta-analysis of IL-10 -1082 G/A polymorphism revealed no association between RPL and the IL-10 -1082 G allele (OR = 0.999, 95{\%} CI = 0.815-1.223, p = 0.989). However, meta-analysis of IL-10 -819 C/T polymorphism in all study subjects revealed an association between RPL and the IL-10 -819 C allele (OR = 0.680, 95{\%} CI = 0.498-0.927, p = 0.015). Stratification by ethnicity indicated an association between the IL-10 -819 C allele and RPL in the Asian group (OR = 0.421, 95{\%} CI = 0.226-0.783, p = 0.006), but not in the Caucasian and Arab groups (OR = 1.053, 95{\%} CI = 0.218-5.077, p = 0.949, and OR = 0.800, 95{\%} CI = 0.606-1.081, p = 0.152, respectively). Furthermore, a relationship between the IL-10 -592 C allele and RPL was identified in the Asian group (OR = 0.763, 95{\%} CI = 0.633-0.919, p = 0.004), but not in the Caucasian and Arab groups. Conclusions The meta-analyses demonstrate that IL-10 -819 C/T and -592 C/A polymorphisms are associated with RPL susceptibility in Asian women, but not in the Caucasian and Arab populations.",
keywords = "Interleukin-10, Meta-analysis, Polymorphism, RPL",
author = "Lee, {Young Ho} and Kim, {Jae Hoon} and Song, {Gwan Gyu}",
year = "2016",
month = "5",
day = "1",
doi = "10.1016/j.ejogrb.2016.02.032",
language = "English",
volume = "200",
pages = "51--57",
journal = "European Journal of Obstetrics and Gynecology and Reproductive Biology",
issn = "0028-2243",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Meta-analyses of associations between interleukin-10 polymorphisms and susceptibility to recurrent pregnancy loss

AU - Lee, Young Ho

AU - Kim, Jae Hoon

AU - Song, Gwan Gyu

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Objective The aim of this study was to investigate whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL). Methods We conducted a literature search using the PubMed and EMBASE databases and performed meta-analyses on the associations between IL-10 -1082 G/A, -819 C/T, and -592 C/A polymorphisms and RPL, using fixed- or random-effects models. Results A total of 15 papers involving 1858 RPL patients and 1949 controls were considered in this study. Meta-analysis of IL-10 -1082 G/A polymorphism revealed no association between RPL and the IL-10 -1082 G allele (OR = 0.999, 95% CI = 0.815-1.223, p = 0.989). However, meta-analysis of IL-10 -819 C/T polymorphism in all study subjects revealed an association between RPL and the IL-10 -819 C allele (OR = 0.680, 95% CI = 0.498-0.927, p = 0.015). Stratification by ethnicity indicated an association between the IL-10 -819 C allele and RPL in the Asian group (OR = 0.421, 95% CI = 0.226-0.783, p = 0.006), but not in the Caucasian and Arab groups (OR = 1.053, 95% CI = 0.218-5.077, p = 0.949, and OR = 0.800, 95% CI = 0.606-1.081, p = 0.152, respectively). Furthermore, a relationship between the IL-10 -592 C allele and RPL was identified in the Asian group (OR = 0.763, 95% CI = 0.633-0.919, p = 0.004), but not in the Caucasian and Arab groups. Conclusions The meta-analyses demonstrate that IL-10 -819 C/T and -592 C/A polymorphisms are associated with RPL susceptibility in Asian women, but not in the Caucasian and Arab populations.

AB - Objective The aim of this study was to investigate whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL). Methods We conducted a literature search using the PubMed and EMBASE databases and performed meta-analyses on the associations between IL-10 -1082 G/A, -819 C/T, and -592 C/A polymorphisms and RPL, using fixed- or random-effects models. Results A total of 15 papers involving 1858 RPL patients and 1949 controls were considered in this study. Meta-analysis of IL-10 -1082 G/A polymorphism revealed no association between RPL and the IL-10 -1082 G allele (OR = 0.999, 95% CI = 0.815-1.223, p = 0.989). However, meta-analysis of IL-10 -819 C/T polymorphism in all study subjects revealed an association between RPL and the IL-10 -819 C allele (OR = 0.680, 95% CI = 0.498-0.927, p = 0.015). Stratification by ethnicity indicated an association between the IL-10 -819 C allele and RPL in the Asian group (OR = 0.421, 95% CI = 0.226-0.783, p = 0.006), but not in the Caucasian and Arab groups (OR = 1.053, 95% CI = 0.218-5.077, p = 0.949, and OR = 0.800, 95% CI = 0.606-1.081, p = 0.152, respectively). Furthermore, a relationship between the IL-10 -592 C allele and RPL was identified in the Asian group (OR = 0.763, 95% CI = 0.633-0.919, p = 0.004), but not in the Caucasian and Arab groups. Conclusions The meta-analyses demonstrate that IL-10 -819 C/T and -592 C/A polymorphisms are associated with RPL susceptibility in Asian women, but not in the Caucasian and Arab populations.

KW - Interleukin-10

KW - Meta-analysis

KW - Polymorphism

KW - RPL

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