Meta-analysis and systematic review on laparoscopic-assisted distal gastrectomy (LADG) and totally laparoscopic distal gastrectomy (TLDG) for gastric cancer: Preliminary study for a multicenter prospective KLASS07 trial

Hyui Eun Jin, Min Seo Kim, Chang Min Lee, Ji Ho Park, Chang In Choi, Han Hong Lee, Jae Seok Min, Ye Seob Jee, Jeong Oh, Hyundong Chae, Sung Il Choi, Yoon Taek Lee, Jong Han Kim, Hua Huang, Sungsoo Park

Research output: Contribution to journalReview article

2 Citations (Scopus)


Background: The curative surgical treatment of gastric cancer in the current laparoscopic surgical era relies on the surgeon's preference, technical difficulties, and concerns regarding outcome have led to the availability of totally laparoscopic distal gastrectomy (TLDG) and laparoscopic-assisted distal gastrectomy (LADG). A consensus on which of the two procedures is preferable is necessary. Therefore, the aim of this study was to evaluate the differences between LADG and TLDG in terms of surgical outcomes, postoperative recovery, pain, and complications. Methods: PubMed, Google Scholar, Medline, Embase, and Cochrane databases were explored up to 2017 to evaluate TLDG and LADG. Parameters including surgical outcomes, postoperative recovery, and postoperative complications were subjected to meta-analysis to calculate the odds ratio and weighted mean difference with 95% confidence intervals (c.i.). Results: Twenty-five studies (24 non-RCT and 1 RCT) with a total of 4562 gastric cancer patients were included in the meta-analysis. Under reconstruction-matched analysis, overall complications and anastomotic complications were similar for TLDG and LADG. Nevertheless, short-term outcomes such as blood loss, time to first soft diet, hospital stay, analgesic use, and CRP level were favourable for TLDG, while all other surgical outcomes showed no difference. Conclusions: TLDG and LADG did not show significant differences in surgical outcomes and postoperative complications, including anastomotic-related morbidity. Therefore, decisive factors in selecting surgical procedures, which previously consisted of surgical outcomes, have been superseded by extra-surgical values such as cosmesis, economics, and patient's quality of life. These factors will be explored in a future multicentre prospective study (KLASS07 trial).

Original languageEnglish
JournalEuropean Journal of Surgical Oncology
Publication statusPublished - 2019 Jan 1



  • Anastomosis
  • Gastric cancer
  • Laparoscopically assisted distal gastrectomy (LADG)
  • Meta-analysis
  • Postoperative complications
  • Totally laparoscopic distal gastrectomy (TLDG)

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this