TY - JOUR
T1 - Meta-analysis of associations between functional prolactin −1149 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus
AU - Lee, Young Ho
AU - Bae, Sang Cheol
AU - Song, Gwan Gyu
N1 - Funding Information:
This study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124).
Publisher Copyright:
© 2015, International League of Associations for Rheumatology (ILAR).
PY - 2015/3/19
Y1 - 2015/3/19
N2 - The aim of this study was to determine whether the prolactin −1149 G/T polymorphism confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). A meta-analysis was conducted for examining the associations between prolactin −1149 G/T polymorphism and susceptibility to SLE or RA using allele contrast, recessive and dominant models, and homozygote contrast. A total of 10 comparative studies, consisting of 4 SLE and 6 RA studies, involving 4252 patients and 4949 controls, were included in the meta-analysis. No association between the prolactin −1149 G allele and SLE was found when all study subjects were considered together (OR = 1.019, 95 % CI = 1.841–1.236, p = 0.845). Stratification by ethnicity also indicated no association between the prolactin G allele and SLE in either Caucasian or Latin American populations. In contrast, a significant association was observed between the prolactin G allele and RA in all subjects (OR = 1.123, 95 % CI = 1.052–1.198, p = 4.6 × 10−5). After stratification by ethnicity, the G allele was found to be significantly associated with RA in Caucasians (OR = 1.112, 95 % CI = 1.041–1.189, p = 0.002). Furthermore, the prolactin −1149 G/T polymorphism was found to be associated with RA in Caucasians under the dominant model and under homozygote contrast. This meta-analysis demonstrates that the prolactin −1149 G/T polymorphism is associated with susceptibility to RA, but not SLE, in Caucasians.
AB - The aim of this study was to determine whether the prolactin −1149 G/T polymorphism confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). A meta-analysis was conducted for examining the associations between prolactin −1149 G/T polymorphism and susceptibility to SLE or RA using allele contrast, recessive and dominant models, and homozygote contrast. A total of 10 comparative studies, consisting of 4 SLE and 6 RA studies, involving 4252 patients and 4949 controls, were included in the meta-analysis. No association between the prolactin −1149 G allele and SLE was found when all study subjects were considered together (OR = 1.019, 95 % CI = 1.841–1.236, p = 0.845). Stratification by ethnicity also indicated no association between the prolactin G allele and SLE in either Caucasian or Latin American populations. In contrast, a significant association was observed between the prolactin G allele and RA in all subjects (OR = 1.123, 95 % CI = 1.052–1.198, p = 4.6 × 10−5). After stratification by ethnicity, the G allele was found to be significantly associated with RA in Caucasians (OR = 1.112, 95 % CI = 1.041–1.189, p = 0.002). Furthermore, the prolactin −1149 G/T polymorphism was found to be associated with RA in Caucasians under the dominant model and under homozygote contrast. This meta-analysis demonstrates that the prolactin −1149 G/T polymorphism is associated with susceptibility to RA, but not SLE, in Caucasians.
KW - Meta-analysis
KW - Polymorphism
KW - Prolactin
KW - Rheumatoid arthritis
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=84925483582&partnerID=8YFLogxK
U2 - 10.1007/s10067-015-2904-3
DO - 10.1007/s10067-015-2904-3
M3 - Article
C2 - 25724680
AN - SCOPUS:84925483582
VL - 34
SP - 683
EP - 690
JO - Clinical Rheumatology
JF - Clinical Rheumatology
SN - 0770-3198
IS - 4
ER -