Meta-analysis of associations between interleukin-10 polymorphisms and susceptibility to pre-eclampsia

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Objective To investigate whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to pre-eclampsia. Methods A meta-analysis was conducted on the associations between IL-10-1082 G/A, -819 C/T and -592 C/A polymorphisms and pre-eclampsia using allele contrast, a recessive model, a dominant model and an additive model. Results Thirteen groups from 11 papers involving 1534 patients with pre-eclampsia and 2271 controls were considered in the meta-analysis. Meta-analysis of the IL-10-1082 G/A polymorphism in 3500 study subjects revealed no association between pre-eclampsia and the IL-10-1082 G allele [odds ratio (OR) 0.890, 95% confidence interval (CI) 0.729-1.087; p = 0.254]. Stratification by ethnicity indicated an association between the IL-10-1082 G allele and pre-eclampsia in the Iranian groups (OR 1.408, 95% CI 1.097-1.807; p = 0.007), but not in the European groups (OR 0.759, 95% CI 0.506-1.136; p = 0.180). Meta-analysis revealed an association between pre-eclampsia and the IL-10-819 C allele in all study subjects (OR 1.296, 95% CI 1.012-1.661; p = 0.040), particularly among the Iranian groups (OR 1.390, 95% CI 1.067-1.811; p = 0.015). Meta-analysis showed no association between pre-eclampsia and the IL-10-592 C allele (OR 1.215, 95% CI 0.967-1.527; p = 0.094) in any groups, except for the Iranian groups (OR 1.380, 95% CI 1.056-1.805; p = 0.018). However, the associations found in the meta-analysis became non-significant after exclusion of the studies in which the controls showed deviation from Hardy-Weinberg equilibrium. Conclusions This meta-analysis suggests that IL-10-1082 G/A, -819 C/T and -592 C/A polymorphisms are unlikely to be important in susceptibility to pre-eclampsia.

Original languageEnglish
Pages (from-to)202-207
Number of pages6
JournalEuropean Journal of Obstetrics Gynecology and Reproductive Biology
Volume182
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Pre-Eclampsia
Interleukin-10
Meta-Analysis
Odds Ratio
Confidence Intervals
Alleles

Keywords

  • Interleukin-10
  • Meta-analysis
  • Polymorphism
  • Pre-eclampsia

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

@article{8b09717873fd4f4990f8d2a69cb2b602,
title = "Meta-analysis of associations between interleukin-10 polymorphisms and susceptibility to pre-eclampsia",
abstract = "Objective To investigate whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to pre-eclampsia. Methods A meta-analysis was conducted on the associations between IL-10-1082 G/A, -819 C/T and -592 C/A polymorphisms and pre-eclampsia using allele contrast, a recessive model, a dominant model and an additive model. Results Thirteen groups from 11 papers involving 1534 patients with pre-eclampsia and 2271 controls were considered in the meta-analysis. Meta-analysis of the IL-10-1082 G/A polymorphism in 3500 study subjects revealed no association between pre-eclampsia and the IL-10-1082 G allele [odds ratio (OR) 0.890, 95{\%} confidence interval (CI) 0.729-1.087; p = 0.254]. Stratification by ethnicity indicated an association between the IL-10-1082 G allele and pre-eclampsia in the Iranian groups (OR 1.408, 95{\%} CI 1.097-1.807; p = 0.007), but not in the European groups (OR 0.759, 95{\%} CI 0.506-1.136; p = 0.180). Meta-analysis revealed an association between pre-eclampsia and the IL-10-819 C allele in all study subjects (OR 1.296, 95{\%} CI 1.012-1.661; p = 0.040), particularly among the Iranian groups (OR 1.390, 95{\%} CI 1.067-1.811; p = 0.015). Meta-analysis showed no association between pre-eclampsia and the IL-10-592 C allele (OR 1.215, 95{\%} CI 0.967-1.527; p = 0.094) in any groups, except for the Iranian groups (OR 1.380, 95{\%} CI 1.056-1.805; p = 0.018). However, the associations found in the meta-analysis became non-significant after exclusion of the studies in which the controls showed deviation from Hardy-Weinberg equilibrium. Conclusions This meta-analysis suggests that IL-10-1082 G/A, -819 C/T and -592 C/A polymorphisms are unlikely to be important in susceptibility to pre-eclampsia.",
keywords = "Interleukin-10, Meta-analysis, Polymorphism, Pre-eclampsia",
author = "Lee, {Young Ho} and Kim, {J. H.} and Song, {Gwan Gyu}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.ejogrb.2014.09.030",
language = "English",
volume = "182",
pages = "202--207",
journal = "European Journal of Obstetrics and Gynecology and Reproductive Biology",
issn = "0028-2243",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Meta-analysis of associations between interleukin-10 polymorphisms and susceptibility to pre-eclampsia

AU - Lee, Young Ho

AU - Kim, J. H.

AU - Song, Gwan Gyu

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective To investigate whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to pre-eclampsia. Methods A meta-analysis was conducted on the associations between IL-10-1082 G/A, -819 C/T and -592 C/A polymorphisms and pre-eclampsia using allele contrast, a recessive model, a dominant model and an additive model. Results Thirteen groups from 11 papers involving 1534 patients with pre-eclampsia and 2271 controls were considered in the meta-analysis. Meta-analysis of the IL-10-1082 G/A polymorphism in 3500 study subjects revealed no association between pre-eclampsia and the IL-10-1082 G allele [odds ratio (OR) 0.890, 95% confidence interval (CI) 0.729-1.087; p = 0.254]. Stratification by ethnicity indicated an association between the IL-10-1082 G allele and pre-eclampsia in the Iranian groups (OR 1.408, 95% CI 1.097-1.807; p = 0.007), but not in the European groups (OR 0.759, 95% CI 0.506-1.136; p = 0.180). Meta-analysis revealed an association between pre-eclampsia and the IL-10-819 C allele in all study subjects (OR 1.296, 95% CI 1.012-1.661; p = 0.040), particularly among the Iranian groups (OR 1.390, 95% CI 1.067-1.811; p = 0.015). Meta-analysis showed no association between pre-eclampsia and the IL-10-592 C allele (OR 1.215, 95% CI 0.967-1.527; p = 0.094) in any groups, except for the Iranian groups (OR 1.380, 95% CI 1.056-1.805; p = 0.018). However, the associations found in the meta-analysis became non-significant after exclusion of the studies in which the controls showed deviation from Hardy-Weinberg equilibrium. Conclusions This meta-analysis suggests that IL-10-1082 G/A, -819 C/T and -592 C/A polymorphisms are unlikely to be important in susceptibility to pre-eclampsia.

AB - Objective To investigate whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to pre-eclampsia. Methods A meta-analysis was conducted on the associations between IL-10-1082 G/A, -819 C/T and -592 C/A polymorphisms and pre-eclampsia using allele contrast, a recessive model, a dominant model and an additive model. Results Thirteen groups from 11 papers involving 1534 patients with pre-eclampsia and 2271 controls were considered in the meta-analysis. Meta-analysis of the IL-10-1082 G/A polymorphism in 3500 study subjects revealed no association between pre-eclampsia and the IL-10-1082 G allele [odds ratio (OR) 0.890, 95% confidence interval (CI) 0.729-1.087; p = 0.254]. Stratification by ethnicity indicated an association between the IL-10-1082 G allele and pre-eclampsia in the Iranian groups (OR 1.408, 95% CI 1.097-1.807; p = 0.007), but not in the European groups (OR 0.759, 95% CI 0.506-1.136; p = 0.180). Meta-analysis revealed an association between pre-eclampsia and the IL-10-819 C allele in all study subjects (OR 1.296, 95% CI 1.012-1.661; p = 0.040), particularly among the Iranian groups (OR 1.390, 95% CI 1.067-1.811; p = 0.015). Meta-analysis showed no association between pre-eclampsia and the IL-10-592 C allele (OR 1.215, 95% CI 0.967-1.527; p = 0.094) in any groups, except for the Iranian groups (OR 1.380, 95% CI 1.056-1.805; p = 0.018). However, the associations found in the meta-analysis became non-significant after exclusion of the studies in which the controls showed deviation from Hardy-Weinberg equilibrium. Conclusions This meta-analysis suggests that IL-10-1082 G/A, -819 C/T and -592 C/A polymorphisms are unlikely to be important in susceptibility to pre-eclampsia.

KW - Interleukin-10

KW - Meta-analysis

KW - Polymorphism

KW - Pre-eclampsia

UR - http://www.scopus.com/inward/record.url?scp=84920646619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920646619&partnerID=8YFLogxK

U2 - 10.1016/j.ejogrb.2014.09.030

DO - 10.1016/j.ejogrb.2014.09.030

M3 - Review article

C2 - 25305663

AN - SCOPUS:84920646619

VL - 182

SP - 202

EP - 207

JO - European Journal of Obstetrics and Gynecology and Reproductive Biology

JF - European Journal of Obstetrics and Gynecology and Reproductive Biology

SN - 0028-2243

ER -