Abstract
Objective: This study determined whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to vasculitis.Methods: A meta-analysis was conducted of the associations between the IL-10-1082 G/A,-819 C/T, and-592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A,-819 C/T,-592 C/A polymorphisms and vasculitis.Results: A total of 21 comparative studies involving 4121 patients and 5504 controls were considered in the meta-analysis. Meta-analysis revealed no association between the IL-10-1082 G allele and vasculitis in all study subjects (OR = 0.927, 95% CI = 0.780-1.102, p = 0.389). However, disease-specific meta-analysis showed an association between Wegeners granulomatosis (WG) and the IL-10-1082 G allele (OR = 0.729, 95% CI = 0.547-0.971, p = 0.031). Meta-analysis revealed an association between vasculitis and the IL-10-819 C allele (OR = 0.804, 95% CI = 0.706-0.916, p = 0.001) in all study subjects and Behcets disease (BD) (OR = 0.724, 95% CI = 0.679-0.781, p < 1.0 × 10-9). Meta-analysis of the IL-10-592 C allele showed an association with vasculitis in all study subjects (OR = 0.805, 95% CI = 0.619-0.938, p = 0.005) and BD (OR = 0.718, 95% CI = 0.661-0.781, p < 1.0 × 10-9). Meta-analysis of the IL-10 haplotype revealed an association between the GCC haplotype and vasculitis in Europeans (OR = 1.239, 95% CI = 1.105-1.513, p = 0.035).Conclusions: This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD.
| Original language | English |
|---|---|
| Pages (from-to) | 553-565 |
| Number of pages | 13 |
| Journal | Immunological Investigations |
| Volume | 44 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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Keywords
- Interleukin-10
- meta-analysis
- polymorphism
- vasculitis
ASJC Scopus subject areas
- Immunology
Cite this
Meta-Analysis of Associations between Interleukin-10 Polymorphisms and Susceptibility to Vasculitis. / Jung, Jae Hyun; Song, Gwan Gyu; Lee, Young Ho.
In: Immunological Investigations, Vol. 44, No. 6, 01.01.2015, p. 553-565.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Meta-Analysis of Associations between Interleukin-10 Polymorphisms and Susceptibility to Vasculitis
AU - Jung, Jae Hyun
AU - Song, Gwan Gyu
AU - Lee, Young Ho
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Objective: This study determined whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to vasculitis.Methods: A meta-analysis was conducted of the associations between the IL-10-1082 G/A,-819 C/T, and-592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A,-819 C/T,-592 C/A polymorphisms and vasculitis.Results: A total of 21 comparative studies involving 4121 patients and 5504 controls were considered in the meta-analysis. Meta-analysis revealed no association between the IL-10-1082 G allele and vasculitis in all study subjects (OR = 0.927, 95% CI = 0.780-1.102, p = 0.389). However, disease-specific meta-analysis showed an association between Wegeners granulomatosis (WG) and the IL-10-1082 G allele (OR = 0.729, 95% CI = 0.547-0.971, p = 0.031). Meta-analysis revealed an association between vasculitis and the IL-10-819 C allele (OR = 0.804, 95% CI = 0.706-0.916, p = 0.001) in all study subjects and Behcets disease (BD) (OR = 0.724, 95% CI = 0.679-0.781, p < 1.0 × 10-9). Meta-analysis of the IL-10-592 C allele showed an association with vasculitis in all study subjects (OR = 0.805, 95% CI = 0.619-0.938, p = 0.005) and BD (OR = 0.718, 95% CI = 0.661-0.781, p < 1.0 × 10-9). Meta-analysis of the IL-10 haplotype revealed an association between the GCC haplotype and vasculitis in Europeans (OR = 1.239, 95% CI = 1.105-1.513, p = 0.035).Conclusions: This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD.
AB - Objective: This study determined whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to vasculitis.Methods: A meta-analysis was conducted of the associations between the IL-10-1082 G/A,-819 C/T, and-592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A,-819 C/T,-592 C/A polymorphisms and vasculitis.Results: A total of 21 comparative studies involving 4121 patients and 5504 controls were considered in the meta-analysis. Meta-analysis revealed no association between the IL-10-1082 G allele and vasculitis in all study subjects (OR = 0.927, 95% CI = 0.780-1.102, p = 0.389). However, disease-specific meta-analysis showed an association between Wegeners granulomatosis (WG) and the IL-10-1082 G allele (OR = 0.729, 95% CI = 0.547-0.971, p = 0.031). Meta-analysis revealed an association between vasculitis and the IL-10-819 C allele (OR = 0.804, 95% CI = 0.706-0.916, p = 0.001) in all study subjects and Behcets disease (BD) (OR = 0.724, 95% CI = 0.679-0.781, p < 1.0 × 10-9). Meta-analysis of the IL-10-592 C allele showed an association with vasculitis in all study subjects (OR = 0.805, 95% CI = 0.619-0.938, p = 0.005) and BD (OR = 0.718, 95% CI = 0.661-0.781, p < 1.0 × 10-9). Meta-analysis of the IL-10 haplotype revealed an association between the GCC haplotype and vasculitis in Europeans (OR = 1.239, 95% CI = 1.105-1.513, p = 0.035).Conclusions: This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD.
KW - Interleukin-10
KW - meta-analysis
KW - polymorphism
KW - vasculitis
UR - http://www.scopus.com/inward/record.url?scp=84939223241&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939223241&partnerID=8YFLogxK
U2 - 10.3109/08820139.2015.1043670
DO - 10.3109/08820139.2015.1043670
M3 - Article
C2 - 26213801
AN - SCOPUS:84939223241
VL - 44
SP - 553
EP - 565
JO - Immunological Investigations
JF - Immunological Investigations
SN - 0882-0139
IS - 6
ER -