Meta-Analysis of Associations between Interleukin-10 Polymorphisms and Susceptibility to Vasculitis

Jae Hyun Jung, Gwan Gyu Song, Young Ho Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: This study determined whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to vasculitis.Methods: A meta-analysis was conducted of the associations between the IL-10-1082 G/A,-819 C/T, and-592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A,-819 C/T,-592 C/A polymorphisms and vasculitis.Results: A total of 21 comparative studies involving 4121 patients and 5504 controls were considered in the meta-analysis. Meta-analysis revealed no association between the IL-10-1082 G allele and vasculitis in all study subjects (OR = 0.927, 95% CI = 0.780-1.102, p = 0.389). However, disease-specific meta-analysis showed an association between Wegeners granulomatosis (WG) and the IL-10-1082 G allele (OR = 0.729, 95% CI = 0.547-0.971, p = 0.031). Meta-analysis revealed an association between vasculitis and the IL-10-819 C allele (OR = 0.804, 95% CI = 0.706-0.916, p = 0.001) in all study subjects and Behcets disease (BD) (OR = 0.724, 95% CI = 0.679-0.781, p < 1.0 × 10-9). Meta-analysis of the IL-10-592 C allele showed an association with vasculitis in all study subjects (OR = 0.805, 95% CI = 0.619-0.938, p = 0.005) and BD (OR = 0.718, 95% CI = 0.661-0.781, p < 1.0 × 10-9). Meta-analysis of the IL-10 haplotype revealed an association between the GCC haplotype and vasculitis in Europeans (OR = 1.239, 95% CI = 1.105-1.513, p = 0.035).Conclusions: This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD.

Original languageEnglish
Pages (from-to)553-565
Number of pages13
JournalImmunological Investigations
Volume44
Issue number6
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Vasculitis
Interleukin-10
Meta-Analysis
Behcet Syndrome
Alleles
Haplotypes
Granulomatosis with Polyangiitis

Keywords

  • Interleukin-10
  • meta-analysis
  • polymorphism
  • vasculitis

ASJC Scopus subject areas

  • Immunology

Cite this

Meta-Analysis of Associations between Interleukin-10 Polymorphisms and Susceptibility to Vasculitis. / Jung, Jae Hyun; Song, Gwan Gyu; Lee, Young Ho.

In: Immunological Investigations, Vol. 44, No. 6, 01.01.2015, p. 553-565.

Research output: Contribution to journalArticle

@article{344c50bce2a94a1dbf3965b6a3ae0992,
title = "Meta-Analysis of Associations between Interleukin-10 Polymorphisms and Susceptibility to Vasculitis",
abstract = "Objective: This study determined whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to vasculitis.Methods: A meta-analysis was conducted of the associations between the IL-10-1082 G/A,-819 C/T, and-592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A,-819 C/T,-592 C/A polymorphisms and vasculitis.Results: A total of 21 comparative studies involving 4121 patients and 5504 controls were considered in the meta-analysis. Meta-analysis revealed no association between the IL-10-1082 G allele and vasculitis in all study subjects (OR = 0.927, 95{\%} CI = 0.780-1.102, p = 0.389). However, disease-specific meta-analysis showed an association between Wegeners granulomatosis (WG) and the IL-10-1082 G allele (OR = 0.729, 95{\%} CI = 0.547-0.971, p = 0.031). Meta-analysis revealed an association between vasculitis and the IL-10-819 C allele (OR = 0.804, 95{\%} CI = 0.706-0.916, p = 0.001) in all study subjects and Behcets disease (BD) (OR = 0.724, 95{\%} CI = 0.679-0.781, p < 1.0 × 10-9). Meta-analysis of the IL-10-592 C allele showed an association with vasculitis in all study subjects (OR = 0.805, 95{\%} CI = 0.619-0.938, p = 0.005) and BD (OR = 0.718, 95{\%} CI = 0.661-0.781, p < 1.0 × 10-9). Meta-analysis of the IL-10 haplotype revealed an association between the GCC haplotype and vasculitis in Europeans (OR = 1.239, 95{\%} CI = 1.105-1.513, p = 0.035).Conclusions: This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD.",
keywords = "Interleukin-10, meta-analysis, polymorphism, vasculitis",
author = "Jung, {Jae Hyun} and Song, {Gwan Gyu} and Lee, {Young Ho}",
year = "2015",
month = "1",
day = "1",
doi = "10.3109/08820139.2015.1043670",
language = "English",
volume = "44",
pages = "553--565",
journal = "Immunological Investigations",
issn = "0882-0139",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - Meta-Analysis of Associations between Interleukin-10 Polymorphisms and Susceptibility to Vasculitis

AU - Jung, Jae Hyun

AU - Song, Gwan Gyu

AU - Lee, Young Ho

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objective: This study determined whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to vasculitis.Methods: A meta-analysis was conducted of the associations between the IL-10-1082 G/A,-819 C/T, and-592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A,-819 C/T,-592 C/A polymorphisms and vasculitis.Results: A total of 21 comparative studies involving 4121 patients and 5504 controls were considered in the meta-analysis. Meta-analysis revealed no association between the IL-10-1082 G allele and vasculitis in all study subjects (OR = 0.927, 95% CI = 0.780-1.102, p = 0.389). However, disease-specific meta-analysis showed an association between Wegeners granulomatosis (WG) and the IL-10-1082 G allele (OR = 0.729, 95% CI = 0.547-0.971, p = 0.031). Meta-analysis revealed an association between vasculitis and the IL-10-819 C allele (OR = 0.804, 95% CI = 0.706-0.916, p = 0.001) in all study subjects and Behcets disease (BD) (OR = 0.724, 95% CI = 0.679-0.781, p < 1.0 × 10-9). Meta-analysis of the IL-10-592 C allele showed an association with vasculitis in all study subjects (OR = 0.805, 95% CI = 0.619-0.938, p = 0.005) and BD (OR = 0.718, 95% CI = 0.661-0.781, p < 1.0 × 10-9). Meta-analysis of the IL-10 haplotype revealed an association between the GCC haplotype and vasculitis in Europeans (OR = 1.239, 95% CI = 1.105-1.513, p = 0.035).Conclusions: This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD.

AB - Objective: This study determined whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to vasculitis.Methods: A meta-analysis was conducted of the associations between the IL-10-1082 G/A,-819 C/T, and-592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A,-819 C/T,-592 C/A polymorphisms and vasculitis.Results: A total of 21 comparative studies involving 4121 patients and 5504 controls were considered in the meta-analysis. Meta-analysis revealed no association between the IL-10-1082 G allele and vasculitis in all study subjects (OR = 0.927, 95% CI = 0.780-1.102, p = 0.389). However, disease-specific meta-analysis showed an association between Wegeners granulomatosis (WG) and the IL-10-1082 G allele (OR = 0.729, 95% CI = 0.547-0.971, p = 0.031). Meta-analysis revealed an association between vasculitis and the IL-10-819 C allele (OR = 0.804, 95% CI = 0.706-0.916, p = 0.001) in all study subjects and Behcets disease (BD) (OR = 0.724, 95% CI = 0.679-0.781, p < 1.0 × 10-9). Meta-analysis of the IL-10-592 C allele showed an association with vasculitis in all study subjects (OR = 0.805, 95% CI = 0.619-0.938, p = 0.005) and BD (OR = 0.718, 95% CI = 0.661-0.781, p < 1.0 × 10-9). Meta-analysis of the IL-10 haplotype revealed an association between the GCC haplotype and vasculitis in Europeans (OR = 1.239, 95% CI = 1.105-1.513, p = 0.035).Conclusions: This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD.

KW - Interleukin-10

KW - meta-analysis

KW - polymorphism

KW - vasculitis

UR - http://www.scopus.com/inward/record.url?scp=84939223241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939223241&partnerID=8YFLogxK

U2 - 10.3109/08820139.2015.1043670

DO - 10.3109/08820139.2015.1043670

M3 - Article

C2 - 26213801

AN - SCOPUS:84939223241

VL - 44

SP - 553

EP - 565

JO - Immunological Investigations

JF - Immunological Investigations

SN - 0882-0139

IS - 6

ER -