Meta-analysis of associations between interleukin-10 polymorphisms and susceptibility to Behcet’s disease

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Abstract

The aim of this study was to determine whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to Behcet’s disease (BD). A meta-analysis was conducted, examining the associations between the IL-10 − 1082 G/A, − 819 C/T, and − 592 C/A polymorphisms and BD in various ethnic groups. Fourteen studies involving 5992 patients and 8966 controls were considered in the meta-analysis. Meta-analysis of the IL-10 − 1082 G/A polymorphism showed no association between BD and the − 1082 G allele (odds ratio (OR) = 0.951, 95% confidence interval (CI) = 0.790–1.146, p = 0.601). Meta-analysis of the IL-10 − 819 C/T polymorphism revealed a significant association between BD and the − 819 C allele (OR = 0.751, 95% CI = 0.684–0.825, p < 0.001) in all study subjects. Stratification by ethnicity indicated a significant association between the − 819 C allele and BD in Turkish (OR = 0.779, 95% CI = 0.709–0.856, p < 0.001) and Asian (OR = 0.676, 95% CI = 0.631–0.725, p < 0.001), but not in Middle Eastern populations. Meta-analysis of the − 592 C allele showed an association with BD in all study subjects (OR = 0.792, 95% CI = 0.662–0.948, p = 0.011) Stratification by ethnicity indicated a significant association between the − 592 C allele and BD in Asian populations (OR = 0.656, 95% CI = 0.512–0.841, p = 0.001). This meta-analysis showed that the IL-10 − 819 C/T and − 592 C/A polymorphisms are associated with BD susceptibility, especially in Asian population.

Original languageEnglish
Pages (from-to)424-431
Number of pages8
JournalImmunologic Research
Volume67
Issue number4-5
DOIs
Publication statusPublished - 2019 Oct 1

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Behcet Syndrome
Interleukin-10
Meta-Analysis
Odds Ratio
Confidence Intervals
Alleles
Population
Disease Susceptibility
Ethnic Groups

Keywords

  • Behcet’s disease
  • Interleukin-10
  • Meta-analysis
  • Polymorphism

ASJC Scopus subject areas

  • Immunology

Cite this

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title = "Meta-analysis of associations between interleukin-10 polymorphisms and susceptibility to Behcet’s disease",
abstract = "The aim of this study was to determine whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to Behcet’s disease (BD). A meta-analysis was conducted, examining the associations between the IL-10 − 1082 G/A, − 819 C/T, and − 592 C/A polymorphisms and BD in various ethnic groups. Fourteen studies involving 5992 patients and 8966 controls were considered in the meta-analysis. Meta-analysis of the IL-10 − 1082 G/A polymorphism showed no association between BD and the − 1082 G allele (odds ratio (OR) = 0.951, 95{\%} confidence interval (CI) = 0.790–1.146, p = 0.601). Meta-analysis of the IL-10 − 819 C/T polymorphism revealed a significant association between BD and the − 819 C allele (OR = 0.751, 95{\%} CI = 0.684–0.825, p < 0.001) in all study subjects. Stratification by ethnicity indicated a significant association between the − 819 C allele and BD in Turkish (OR = 0.779, 95{\%} CI = 0.709–0.856, p < 0.001) and Asian (OR = 0.676, 95{\%} CI = 0.631–0.725, p < 0.001), but not in Middle Eastern populations. Meta-analysis of the − 592 C allele showed an association with BD in all study subjects (OR = 0.792, 95{\%} CI = 0.662–0.948, p = 0.011) Stratification by ethnicity indicated a significant association between the − 592 C allele and BD in Asian populations (OR = 0.656, 95{\%} CI = 0.512–0.841, p = 0.001). This meta-analysis showed that the IL-10 − 819 C/T and − 592 C/A polymorphisms are associated with BD susceptibility, especially in Asian population.",
keywords = "Behcet’s disease, Interleukin-10, Meta-analysis, Polymorphism",
author = "Lee, {Young Ho} and Song, {Gwan Gyu}",
year = "2019",
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doi = "10.1007/s12026-019-09102-x",
language = "English",
volume = "67",
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journal = "Immunologic Research",
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AU - Lee, Young Ho

AU - Song, Gwan Gyu

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N2 - The aim of this study was to determine whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to Behcet’s disease (BD). A meta-analysis was conducted, examining the associations between the IL-10 − 1082 G/A, − 819 C/T, and − 592 C/A polymorphisms and BD in various ethnic groups. Fourteen studies involving 5992 patients and 8966 controls were considered in the meta-analysis. Meta-analysis of the IL-10 − 1082 G/A polymorphism showed no association between BD and the − 1082 G allele (odds ratio (OR) = 0.951, 95% confidence interval (CI) = 0.790–1.146, p = 0.601). Meta-analysis of the IL-10 − 819 C/T polymorphism revealed a significant association between BD and the − 819 C allele (OR = 0.751, 95% CI = 0.684–0.825, p < 0.001) in all study subjects. Stratification by ethnicity indicated a significant association between the − 819 C allele and BD in Turkish (OR = 0.779, 95% CI = 0.709–0.856, p < 0.001) and Asian (OR = 0.676, 95% CI = 0.631–0.725, p < 0.001), but not in Middle Eastern populations. Meta-analysis of the − 592 C allele showed an association with BD in all study subjects (OR = 0.792, 95% CI = 0.662–0.948, p = 0.011) Stratification by ethnicity indicated a significant association between the − 592 C allele and BD in Asian populations (OR = 0.656, 95% CI = 0.512–0.841, p = 0.001). This meta-analysis showed that the IL-10 − 819 C/T and − 592 C/A polymorphisms are associated with BD susceptibility, especially in Asian population.

AB - The aim of this study was to determine whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to Behcet’s disease (BD). A meta-analysis was conducted, examining the associations between the IL-10 − 1082 G/A, − 819 C/T, and − 592 C/A polymorphisms and BD in various ethnic groups. Fourteen studies involving 5992 patients and 8966 controls were considered in the meta-analysis. Meta-analysis of the IL-10 − 1082 G/A polymorphism showed no association between BD and the − 1082 G allele (odds ratio (OR) = 0.951, 95% confidence interval (CI) = 0.790–1.146, p = 0.601). Meta-analysis of the IL-10 − 819 C/T polymorphism revealed a significant association between BD and the − 819 C allele (OR = 0.751, 95% CI = 0.684–0.825, p < 0.001) in all study subjects. Stratification by ethnicity indicated a significant association between the − 819 C allele and BD in Turkish (OR = 0.779, 95% CI = 0.709–0.856, p < 0.001) and Asian (OR = 0.676, 95% CI = 0.631–0.725, p < 0.001), but not in Middle Eastern populations. Meta-analysis of the − 592 C allele showed an association with BD in all study subjects (OR = 0.792, 95% CI = 0.662–0.948, p = 0.011) Stratification by ethnicity indicated a significant association between the − 592 C allele and BD in Asian populations (OR = 0.656, 95% CI = 0.512–0.841, p = 0.001). This meta-analysis showed that the IL-10 − 819 C/T and − 592 C/A polymorphisms are associated with BD susceptibility, especially in Asian population.

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