Abstract
We examined whether methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) polymorphisms are associated with susceptibility to multiple sclerosis (MS). We performed a meta-analysis on the association between MS and the following genotypes: MTHFR C677T, A1298C, and GSTP1 A313G polymorphisms, and GSTM1 and GSTT1 null alleles. Fifteen comparisons involving 2,486 patients and 2,861 controls were considered. Meta-analysis of all study subjects considered together showed no association between MS and the MTHFR 677 T allele (OR = 1.014, 95 % CI 0.803–1.280, p = 0.909). Stratification by ethnicity showed no similar association in Caucasian and Arab populations. Likewise, no link was found between MS and the MTHFR 1298 C allele in the total data (OR = 2.477, 95 % CI 0.507–12.10, p = 0.263), nor when it was stratified by ethnicity. No association with MS was observed in relation to the GSTM1 null genotype in Caucasian populations (OR = 1.229, 95 % CI 0.693–2.181, p = 0.481), nor with the GSTP1 A313G polymorphism (OR for G allele = 1.133, 95 % CI 0.903–1.421, p = 0.281). However, there was an association between MS and the GSTT1 null genotype in data obtained from Caucasian populations (OR = 1.945, 95 % CI 1.452–2.605, p = 8.6 × 10−7). GSTT1 null genotype is associated with MS in Caucasian populations; however, no association was found between MS and polymorphisms of MTHFR, GSTM1, and GSTP1.
| Original language | English |
|---|---|
| Pages (from-to) | 2089-2096 |
| Number of pages | 8 |
| Journal | Neurological Sciences |
| Volume | 36 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2015 Jul 7 |
Fingerprint
Keywords
- GSTs
- Meta-analysis
- MTHFR
- Multiple sclerosis
- Polymorphism
ASJC Scopus subject areas
- Dermatology
- Clinical Neurology
- Psychiatry and Mental health
Cite this
Meta-analysis of associations between MTHFR and GST polymorphisms and susceptibility to multiple sclerosis. / Lee, Young Ho; Seo, Young Ho; Kim, Jae Hoon; Choi, Sungjae; Ji, Jong Dae; Song, Gwan Gyu.
In: Neurological Sciences, Vol. 36, No. 11, 07.07.2015, p. 2089-2096.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Meta-analysis of associations between MTHFR and GST polymorphisms and susceptibility to multiple sclerosis
AU - Lee, Young Ho
AU - Seo, Young Ho
AU - Kim, Jae Hoon
AU - Choi, Sungjae
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
PY - 2015/7/7
Y1 - 2015/7/7
N2 - We examined whether methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) polymorphisms are associated with susceptibility to multiple sclerosis (MS). We performed a meta-analysis on the association between MS and the following genotypes: MTHFR C677T, A1298C, and GSTP1 A313G polymorphisms, and GSTM1 and GSTT1 null alleles. Fifteen comparisons involving 2,486 patients and 2,861 controls were considered. Meta-analysis of all study subjects considered together showed no association between MS and the MTHFR 677 T allele (OR = 1.014, 95 % CI 0.803–1.280, p = 0.909). Stratification by ethnicity showed no similar association in Caucasian and Arab populations. Likewise, no link was found between MS and the MTHFR 1298 C allele in the total data (OR = 2.477, 95 % CI 0.507–12.10, p = 0.263), nor when it was stratified by ethnicity. No association with MS was observed in relation to the GSTM1 null genotype in Caucasian populations (OR = 1.229, 95 % CI 0.693–2.181, p = 0.481), nor with the GSTP1 A313G polymorphism (OR for G allele = 1.133, 95 % CI 0.903–1.421, p = 0.281). However, there was an association between MS and the GSTT1 null genotype in data obtained from Caucasian populations (OR = 1.945, 95 % CI 1.452–2.605, p = 8.6 × 10−7). GSTT1 null genotype is associated with MS in Caucasian populations; however, no association was found between MS and polymorphisms of MTHFR, GSTM1, and GSTP1.
AB - We examined whether methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) polymorphisms are associated with susceptibility to multiple sclerosis (MS). We performed a meta-analysis on the association between MS and the following genotypes: MTHFR C677T, A1298C, and GSTP1 A313G polymorphisms, and GSTM1 and GSTT1 null alleles. Fifteen comparisons involving 2,486 patients and 2,861 controls were considered. Meta-analysis of all study subjects considered together showed no association between MS and the MTHFR 677 T allele (OR = 1.014, 95 % CI 0.803–1.280, p = 0.909). Stratification by ethnicity showed no similar association in Caucasian and Arab populations. Likewise, no link was found between MS and the MTHFR 1298 C allele in the total data (OR = 2.477, 95 % CI 0.507–12.10, p = 0.263), nor when it was stratified by ethnicity. No association with MS was observed in relation to the GSTM1 null genotype in Caucasian populations (OR = 1.229, 95 % CI 0.693–2.181, p = 0.481), nor with the GSTP1 A313G polymorphism (OR for G allele = 1.133, 95 % CI 0.903–1.421, p = 0.281). However, there was an association between MS and the GSTT1 null genotype in data obtained from Caucasian populations (OR = 1.945, 95 % CI 1.452–2.605, p = 8.6 × 10−7). GSTT1 null genotype is associated with MS in Caucasian populations; however, no association was found between MS and polymorphisms of MTHFR, GSTM1, and GSTP1.
KW - GSTs
KW - Meta-analysis
KW - MTHFR
KW - Multiple sclerosis
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=84945435251&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84945435251&partnerID=8YFLogxK
U2 - 10.1007/s10072-015-2318-7
DO - 10.1007/s10072-015-2318-7
M3 - Article
VL - 36
SP - 2089
EP - 2096
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 11
ER -