Abstract
Objective: The aim of this study was to determine whether the serotonin transporter-linked polymorphic region (5-HTTLPR) L (long)/S (short) polymorphism is associated with susceptibility to ADHD. Method: We conducted a meta-analysis of case-control associations and the transmission disequilibrium test (TDT) between the 5-HTTLPR L/S polymorphism and ADHD. Results: A total of 19 comparison studies were included in this meta-analysis. Our meta-analysis of the case-control studies showed no association between ADHD and the 5-HTTLPR S allele, for all study participants (odds ratio [OR] = 1.075, 95% confidence interval [CI] = [0.990, 1.167], p =.085), or for the European or Asian population. The TDT indicated no association between ADHD and the 5-HTTLPR S allele, for all study participants (OR = 1.078, 95% CI = [0.962, 1.207], p =.196). Conclusion: This meta-analysis of case-control studies and TDT showed a lack of association between the 5-HTTLPR L/S polymorphism and ADHD.
| Original language | English |
|---|---|
| Pages (from-to) | 901-908 |
| Number of pages | 8 |
| Journal | Journal of Attention Disorders |
| Volume | 22 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2018 Jul 1 |
Fingerprint
Keywords
- 5-HTTLPR
- ADHD
- meta-analysis
- polymorphism
ASJC Scopus subject areas
- Developmental and Educational Psychology
- Clinical Psychology
Cite this
Meta-Analysis of Case-Control and Family-Based Associations Between the 5-HTTLPR L/S Polymorphism and Susceptibility to ADHD. / Lee, Young Ho; Song, Gwan Gyu.
In: Journal of Attention Disorders, Vol. 22, No. 9, 01.07.2018, p. 901-908.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Meta-Analysis of Case-Control and Family-Based Associations Between the 5-HTTLPR L/S Polymorphism and Susceptibility to ADHD
AU - Lee, Young Ho
AU - Song, Gwan Gyu
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Objective: The aim of this study was to determine whether the serotonin transporter-linked polymorphic region (5-HTTLPR) L (long)/S (short) polymorphism is associated with susceptibility to ADHD. Method: We conducted a meta-analysis of case-control associations and the transmission disequilibrium test (TDT) between the 5-HTTLPR L/S polymorphism and ADHD. Results: A total of 19 comparison studies were included in this meta-analysis. Our meta-analysis of the case-control studies showed no association between ADHD and the 5-HTTLPR S allele, for all study participants (odds ratio [OR] = 1.075, 95% confidence interval [CI] = [0.990, 1.167], p =.085), or for the European or Asian population. The TDT indicated no association between ADHD and the 5-HTTLPR S allele, for all study participants (OR = 1.078, 95% CI = [0.962, 1.207], p =.196). Conclusion: This meta-analysis of case-control studies and TDT showed a lack of association between the 5-HTTLPR L/S polymorphism and ADHD.
AB - Objective: The aim of this study was to determine whether the serotonin transporter-linked polymorphic region (5-HTTLPR) L (long)/S (short) polymorphism is associated with susceptibility to ADHD. Method: We conducted a meta-analysis of case-control associations and the transmission disequilibrium test (TDT) between the 5-HTTLPR L/S polymorphism and ADHD. Results: A total of 19 comparison studies were included in this meta-analysis. Our meta-analysis of the case-control studies showed no association between ADHD and the 5-HTTLPR S allele, for all study participants (odds ratio [OR] = 1.075, 95% confidence interval [CI] = [0.990, 1.167], p =.085), or for the European or Asian population. The TDT indicated no association between ADHD and the 5-HTTLPR S allele, for all study participants (OR = 1.078, 95% CI = [0.962, 1.207], p =.196). Conclusion: This meta-analysis of case-control studies and TDT showed a lack of association between the 5-HTTLPR L/S polymorphism and ADHD.
KW - 5-HTTLPR
KW - ADHD
KW - meta-analysis
KW - polymorphism
UR - http://www.scopus.com/inward/record.url?scp=85049054030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049054030&partnerID=8YFLogxK
U2 - 10.1177/1087054715587940
DO - 10.1177/1087054715587940
M3 - Article
C2 - 26048879
AN - SCOPUS:85049054030
VL - 22
SP - 901
EP - 908
JO - Journal of Attention Disorders
JF - Journal of Attention Disorders
SN - 1087-0547
IS - 9
ER -