Meta-analysis of genetic association studies

Young Ho Lee

    Research output: Contribution to journalArticlepeer-review

    73 Citations (Scopus)

    Abstract

    The object of this review is to help readers to understand meta-analysis of genetic association study. Genetic association studies are a powerful approach to identify susceptibility genes for common diseases. However, the results of these studies are not consistently reproducible. In order to overcome the limitations of individual studies, larger sample sizes or meta-analysis is required. Meta-analysis is a statistical tool for combining results of different studies on the same topic, thus increasing statistical strength and precision. Meta-analysis of genetic association studies combines the results from independent studies, explores the sources of heterogeneity, and identifies subgroups associated with the factor of interest. Meta-analysis of genetic association studies is an effective tool for garnering a greater understanding of complex diseases and potentially provides new insights into gene-disease associations.

    Original languageEnglish
    Pages (from-to)283-287
    Number of pages5
    JournalAnnals of laboratory medicine
    Volume35
    Issue number3
    DOIs
    Publication statusPublished - 2015 May 1

    Keywords

    • Association study
    • Gene
    • Meta-analysis
    • Polymorphism

    ASJC Scopus subject areas

    • Clinical Biochemistry
    • Biochemistry, medical

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