Metaanalyse von Genpolymorphismen beim programmierten Zelltod 1: Assoziationen mit der Suzeptibiliät für rheumatoide Arthritis, ankylosierende Spondylitis und Typ-1-Diabetes

Translated title of the contribution: Meta-analysis of genetic polymorphisms in programmed cell death 1: Associations with rheumatoid arthritis, ankylosing spondylitis, and type 1 diabetes susceptibility

Young Ho Lee, S. C. Bae, J. H. Kim, Gwan Gyu Song

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: The aim of this study was to determine whether genetic polymorphisms in programmed cell death 1 (PDCD1 or PD1) are associated with susceptibility to rheumatoid arthritis (RA), ankylosing spondylitis (AS), and type 1 diabetes (T1D).

Methods: We conducted a meta-analysis to investigate the association between PDCD1 polymorphisms and RA, AS, and T1D in the overall population and in specific ethnic populations.

Results: Sixteen studies, comprising 13,210 patients and 17,073 controls, were conducted for the meta-analysis including 4 studies on RA, 4 on AS, and 8 on T1D. The meta-analysis showed an association between RA and the 2 alleles of the PD1.3 polymorphism in the overall population [odds ratio (OR) 1.183, 95 % confidence interval (95 % CI) 1.005–1.392, p = 0.043]. However, meta-analysis showed no association between RA and the 2 alleles of the PD1.1 and PD1.5 polymorphisms in the overall population. Meta-analysis identified an association between AS and the 2 alleles of the PD1.5 and PD1.9 polymorphisms in the Asian population (OR 1.251, 95 % CI 1.019–1.535, p = 0.033; OR 1.975, 95 % CI 1.286–3.034, p = 0.002, respectively). The meta-analysis revealed a significant association between T1D and the 2 alleles of the PD1.3 polymorphism in the European population (OR 1.098, 95 % CI 1.029–1.171, p = 0.005). The meta-analysis showed an association between the PD1.5 polymorphism and T1D in Asians (OR 1.332, 95 % CI 1.067–1.663, p = 0.011) and between the PD1.9 polymorphism and T1D in the Asian population (OR 1.363, 95 % CI 1.107–1.679, p = 0.004).

Conclusion: The meta-analysis suggests an association between the PD1.3 polymorphism and RA in the overall population and an association between the PD1.5 and PD1.9 polymorphisms, and AS in the Asian population. Furthermore, the PD1.3, 5, and 9 polymorphisms were associated with T1D susceptibility in Europeans, or Asians.

Translated title of the contributionMeta-analysis of genetic polymorphisms in programmed cell death 1: Associations with rheumatoid arthritis, ankylosing spondylitis, and type 1 diabetes susceptibility
Original languageGerman
Pages (from-to)230-239
Number of pages10
JournalZeitschrift fur Rheumatologie
Volume74
Issue number3
DOIs
Publication statusPublished - 2015 Apr 1

Keywords

  • Apoptosis
  • Autoimmune diseases
  • Gene frequency
  • Inflammation
  • Peripheral tolerance

ASJC Scopus subject areas

  • Rheumatology

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