Abstract
Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10-13), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10-10) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10-9). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.
| Original language | English |
|---|---|
| Article number | ddv494 |
| Pages (from-to) | 620-629 |
| Number of pages | 10 |
| Journal | Human Molecular Genetics |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2016 Feb 1 |
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ASJC Scopus subject areas
- Genetics
- Genetics(clinical)
- Molecular Biology
Cite this
Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. / Wang, Zhaoming; Seow, Wei Jie; Shiraishi, Kouya; Hsiung, Chao A.; Matsuo, Keitaro; Liu, Jie; Chen, Kexin; Yamji, Taiki; Yang, Yang; Chang, I. Shou; Wu, Chen; Hong, Yun Chul; Burdett, Laurie; Wyatt, Kathleen; Chung, Charles C.; Li, Shengchao A.; Yeager, Meredith; Hutchinson, Amy; Hu, Wei; Caporaso, Neil; Landi, Maria T.; Chatterjee, Nilanjan; Song, Minsun; Fraumeni, Joseph F.; Kohno, Takashi; Yokota, Jun; Kunitoh, Hideo; Ashikawa, Kyota; Momozawa, Yukihide; Daigo, Yataro; Mitsudomi, Tetsuya; Yatabe, Yasushi; Hida, Toyoaki; Hu, Zhibin; Dai, Juncheng; Ma, Hongxia; Jin, Guangfu; Song, Bao; Wang, Zhehai; Cheng, Sensen; Yin, Zhihua; Li, Xuelian; Ren, Yangwu; Guan, Peng; Chang, Jiang; Tan, Wen; Chen, Chien Jen; Chang, Gee Chen; Tsai, Ying Huang; Su, Wu Chou; Chen, Kuan Yu; Huang, Ming Shyan; Chen, Yuh Min; Zheng, Hong; Li, Haixin; Cui, Ping; Guo, Huan; Xu, Ping; Liu, Li; Iwasaki, Motoki; Shimazu, Taichi; Tsugane, Shoichiro; Zhu, Junjie; Jiang, Gening; Fei, Ke; Park, Jae Yong; Kim, Yeul Hong; Sung, Jae Sook; Park, Kyong Hwa; Kim, Young Tae; Jung, Yoo Jin; Kang, Chang Hyun; Park, In Kyu; Kim, Hee Nam; Jeon, Hyo Sung; Choi, Jin Eun; Choi, Yi Young; Kim, Jin Hee; Oh, In Jae; Kim, Young Chul; Sung, Sook Whan; Kim, Jun Suk; Yoon, Ho Il; Kweon, Sun Seog; Shin, Min Ho; Seow, Adeline; Chen, Ying; Lim, Wei Yen; Liu, Jianjun; Wong, Maria Pik; Lee, Victor Ho Fun; Bassig, Bryan A.; Tucker, Margaret; Berndt, Sonja I.; Chow, Wong Ho; Ji, Bu Tian; Wang, Junwen; Xu, Jun; Sihoe, Alan Dart Loon; Ho, James C M; Chan, John K C; Wang, Jiu Cun; Lu, Daru; Zhao, Xueying; Zhao, Zhenhong; Wu, Junjie; Chen, Hongyan; Jin, Li; Wei, Fusheng; Wu, Guoping; An, She Juan; Zhang, Xu Chao; Su, Jian; Wu, Yi Long; Gao, Yu Tang; Xiang, Yong Bing; He, Xingzhou; Li, Jihua; Zheng, Wei; Shu, Xiao Ou; Cai, Qiuyin; Klein, Robert; Pao, William; Lawrence, Charles; Hosgood, H. Dean; Hsiao, Chin Fu; Chien, Li Hsin; Chen, Ying Hsiang; Chen, Chung Hsing; Wang, Wen Chang; Chen, Chih Yi; Wang, Chih Liang; Yu, Chong Jen; Chen, Hui Ling; Su, Yu Chun; Tsai, Fang Yu; Chen, Yi Song; Li, Yao Jen; Yang, Tsung Ying; Lin, Chien Chung; Yang, Pan Chyr; Wu, Tangchun; Lin, Dongxin; Zhou, Baosen; Yu, Jinming; Shen, Hongbing; Kubo, Michiaki; Chanock, Stephen J.; Rothman, Nathaniel; Lan, Qing.
In: Human Molecular Genetics, Vol. 25, No. 3, ddv494, 01.02.2016, p. 620-629.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women
AU - Wang, Zhaoming
AU - Seow, Wei Jie
AU - Shiraishi, Kouya
AU - Hsiung, Chao A.
AU - Matsuo, Keitaro
AU - Liu, Jie
AU - Chen, Kexin
AU - Yamji, Taiki
AU - Yang, Yang
AU - Chang, I. Shou
AU - Wu, Chen
AU - Hong, Yun Chul
AU - Burdett, Laurie
AU - Wyatt, Kathleen
AU - Chung, Charles C.
AU - Li, Shengchao A.
AU - Yeager, Meredith
AU - Hutchinson, Amy
AU - Hu, Wei
AU - Caporaso, Neil
AU - Landi, Maria T.
AU - Chatterjee, Nilanjan
AU - Song, Minsun
AU - Fraumeni, Joseph F.
AU - Kohno, Takashi
AU - Yokota, Jun
AU - Kunitoh, Hideo
AU - Ashikawa, Kyota
AU - Momozawa, Yukihide
AU - Daigo, Yataro
AU - Mitsudomi, Tetsuya
AU - Yatabe, Yasushi
AU - Hida, Toyoaki
AU - Hu, Zhibin
AU - Dai, Juncheng
AU - Ma, Hongxia
AU - Jin, Guangfu
AU - Song, Bao
AU - Wang, Zhehai
AU - Cheng, Sensen
AU - Yin, Zhihua
AU - Li, Xuelian
AU - Ren, Yangwu
AU - Guan, Peng
AU - Chang, Jiang
AU - Tan, Wen
AU - Chen, Chien Jen
AU - Chang, Gee Chen
AU - Tsai, Ying Huang
AU - Su, Wu Chou
AU - Chen, Kuan Yu
AU - Huang, Ming Shyan
AU - Chen, Yuh Min
AU - Zheng, Hong
AU - Li, Haixin
AU - Cui, Ping
AU - Guo, Huan
AU - Xu, Ping
AU - Liu, Li
AU - Iwasaki, Motoki
AU - Shimazu, Taichi
AU - Tsugane, Shoichiro
AU - Zhu, Junjie
AU - Jiang, Gening
AU - Fei, Ke
AU - Park, Jae Yong
AU - Kim, Yeul Hong
AU - Sung, Jae Sook
AU - Park, Kyong Hwa
AU - Kim, Young Tae
AU - Jung, Yoo Jin
AU - Kang, Chang Hyun
AU - Park, In Kyu
AU - Kim, Hee Nam
AU - Jeon, Hyo Sung
AU - Choi, Jin Eun
AU - Choi, Yi Young
AU - Kim, Jin Hee
AU - Oh, In Jae
AU - Kim, Young Chul
AU - Sung, Sook Whan
AU - Kim, Jun Suk
AU - Yoon, Ho Il
AU - Kweon, Sun Seog
AU - Shin, Min Ho
AU - Seow, Adeline
AU - Chen, Ying
AU - Lim, Wei Yen
AU - Liu, Jianjun
AU - Wong, Maria Pik
AU - Lee, Victor Ho Fun
AU - Bassig, Bryan A.
AU - Tucker, Margaret
AU - Berndt, Sonja I.
AU - Chow, Wong Ho
AU - Ji, Bu Tian
AU - Wang, Junwen
AU - Xu, Jun
AU - Sihoe, Alan Dart Loon
AU - Ho, James C M
AU - Chan, John K C
AU - Wang, Jiu Cun
AU - Lu, Daru
AU - Zhao, Xueying
AU - Zhao, Zhenhong
AU - Wu, Junjie
AU - Chen, Hongyan
AU - Jin, Li
AU - Wei, Fusheng
AU - Wu, Guoping
AU - An, She Juan
AU - Zhang, Xu Chao
AU - Su, Jian
AU - Wu, Yi Long
AU - Gao, Yu Tang
AU - Xiang, Yong Bing
AU - He, Xingzhou
AU - Li, Jihua
AU - Zheng, Wei
AU - Shu, Xiao Ou
AU - Cai, Qiuyin
AU - Klein, Robert
AU - Pao, William
AU - Lawrence, Charles
AU - Hosgood, H. Dean
AU - Hsiao, Chin Fu
AU - Chien, Li Hsin
AU - Chen, Ying Hsiang
AU - Chen, Chung Hsing
AU - Wang, Wen Chang
AU - Chen, Chih Yi
AU - Wang, Chih Liang
AU - Yu, Chong Jen
AU - Chen, Hui Ling
AU - Su, Yu Chun
AU - Tsai, Fang Yu
AU - Chen, Yi Song
AU - Li, Yao Jen
AU - Yang, Tsung Ying
AU - Lin, Chien Chung
AU - Yang, Pan Chyr
AU - Wu, Tangchun
AU - Lin, Dongxin
AU - Zhou, Baosen
AU - Yu, Jinming
AU - Shen, Hongbing
AU - Kubo, Michiaki
AU - Chanock, Stephen J.
AU - Rothman, Nathaniel
AU - Lan, Qing
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10-13), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10-10) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10-9). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.
AB - Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10-13), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10-10) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10-9). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.
UR - http://www.scopus.com/inward/record.url?scp=84960858474&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960858474&partnerID=8YFLogxK
U2 - 10.1093/hmg/ddv494
DO - 10.1093/hmg/ddv494
M3 - Article
C2 - 26732429
AN - SCOPUS:84960858474
VL - 25
SP - 620
EP - 629
JO - Human Molecular Genetics
JF - Human Molecular Genetics
SN - 0964-6906
IS - 3
M1 - ddv494
ER -