Abstract
Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10-13), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10-10) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10-9). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.
| Original language | English |
|---|---|
| Pages (from-to) | 620-629 |
| Number of pages | 10 |
| Journal | Human Molecular Genetics |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2016 Feb 1 |
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Genetics(clinical)
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Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. / Wang, Zhaoming; Seow, Wei Jie; Shiraishi, Kouya; Hsiung, Chao A.; Matsuo, Keitaro; Liu, Jie; Chen, Kexin; Yamji, Taiki; Yang, Yang; Chang, I. Shou; Wu, Chen; Hong, Yun Chul; Burdett, Laurie; Wyatt, Kathleen; Chung, Charles C.; Li, Shengchao A.; Yeager, Meredith; Hutchinson, Amy; Hu, Wei; Caporaso, Neil; Landi, Maria T.; Chatterjee, Nilanjan; Song, Minsun; Fraumeni, Joseph F.; Kohno, Takashi; Yokota, Jun; Kunitoh, Hideo; Ashikawa, Kyota; Momozawa, Yukihide; Daigo, Yataro; Mitsudomi, Tetsuya; Yatabe, Yasushi; Hida, Toyoaki; Hu, Zhibin; Dai, Juncheng; Ma, Hongxia; Jin, Guangfu; Song, Bao; Wang, Zhehai; Cheng, Sensen; Yin, Zhihua; Li, Xuelian; Ren, Yangwu; Guan, Peng; Chang, Jiang; Tan, Wen; Chen, Chien Jen; Chang, Gee Chen; Tsai, Ying Huang; Su, Wu Chou; Chen, Kuan Yu; Huang, Ming Shyan; Chen, Yuh Min; Zheng, Hong; Li, Haixin; Cui, Ping; Guo, Huan; Xu, Ping; Liu, Li; Iwasaki, Motoki; Shimazu, Taichi; Tsugane, Shoichiro; Zhu, Junjie; Jiang, Gening; Fei, Ke; Park, Jae Yong; Kim, Yeul Hong; Sung, Jae Sook; Park, Kyong Hwa; Kim, Young Tae; Jung, Yoo Jin; Kang, Chang Hyun; Park, In Kyu; Kim, Hee Nam; Jeon, Hyo Sung; Choi, Jin Eun; Choi, Yi Young; Kim, Jin Hee; Oh, In Jae; Kim, Young Chul; Sung, Sook Whan; Kim, Jun Suk; Yoon, Ho Il; Kweon, Sun Seog; Shin, Min Ho; Seow, Adeline; Chen, Ying; Lim, Wei Yen; Liu, Jianjun; Wong, Maria Pik; Lee, Victor Ho Fun; Bassig, Bryan A.; Tucker, Margaret; Berndt, Sonja I.; Chow, Wong Ho; Ji, Bu Tian; Wang, Junwen; Xu, Jun; Sihoe, Alan Dart Loon; Ho, James C.M.; Chan, John K.C.; Wang, Jiu Cun; Lu, Daru; Zhao, Xueying; Zhao, Zhenhong; Wu, Junjie; Chen, Hongyan; Jin, Li; Wei, Fusheng; Wu, Guoping; An, She Juan; Zhang, Xu Chao; Su, Jian; Wu, Yi Long; Gao, Yu Tang; Xiang, Yong Bing; He, Xingzhou; Li, Jihua; Zheng, Wei; Shu, Xiao Ou; Cai, Qiuyin; Klein, Robert; Pao, William; Lawrence, Charles; Hosgood, H. Dean; Hsiao, Chin Fu; Chien, Li Hsin; Chen, Ying Hsiang; Chen, Chung Hsing; Wang, Wen Chang; Chen, Chih Yi; Wang, Chih Liang; Yu, Chong Jen; Chen, Hui Ling; Su, Yu Chun; Tsai, Fang Yu; Chen, Yi Song; Li, Yao Jen; Yang, Tsung Ying; Lin, Chien Chung; Yang, Pan Chyr; Wu, Tangchun; Lin, Dongxin; Zhou, Baosen; Yu, Jinming; Shen, Hongbing; Kubo, Michiaki; Chanock, Stephen J.; Rothman, Nathaniel; Lan, Qing.
In: Human Molecular Genetics, Vol. 25, No. 3, 01.02.2016, p. 620-629.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women
AU - Wang, Zhaoming
AU - Seow, Wei Jie
AU - Shiraishi, Kouya
AU - Hsiung, Chao A.
AU - Matsuo, Keitaro
AU - Liu, Jie
AU - Chen, Kexin
AU - Yamji, Taiki
AU - Yang, Yang
AU - Chang, I. Shou
AU - Wu, Chen
AU - Hong, Yun Chul
AU - Burdett, Laurie
AU - Wyatt, Kathleen
AU - Chung, Charles C.
AU - Li, Shengchao A.
AU - Yeager, Meredith
AU - Hutchinson, Amy
AU - Hu, Wei
AU - Caporaso, Neil
AU - Landi, Maria T.
AU - Chatterjee, Nilanjan
AU - Song, Minsun
AU - Fraumeni, Joseph F.
AU - Kohno, Takashi
AU - Yokota, Jun
AU - Kunitoh, Hideo
AU - Ashikawa, Kyota
AU - Momozawa, Yukihide
AU - Daigo, Yataro
AU - Mitsudomi, Tetsuya
AU - Yatabe, Yasushi
AU - Hida, Toyoaki
AU - Hu, Zhibin
AU - Dai, Juncheng
AU - Ma, Hongxia
AU - Jin, Guangfu
AU - Song, Bao
AU - Wang, Zhehai
AU - Cheng, Sensen
AU - Yin, Zhihua
AU - Li, Xuelian
AU - Ren, Yangwu
AU - Guan, Peng
AU - Chang, Jiang
AU - Tan, Wen
AU - Chen, Chien Jen
AU - Chang, Gee Chen
AU - Tsai, Ying Huang
AU - Su, Wu Chou
AU - Chen, Kuan Yu
AU - Huang, Ming Shyan
AU - Chen, Yuh Min
AU - Zheng, Hong
AU - Li, Haixin
AU - Cui, Ping
AU - Guo, Huan
AU - Xu, Ping
AU - Liu, Li
AU - Iwasaki, Motoki
AU - Shimazu, Taichi
AU - Tsugane, Shoichiro
AU - Zhu, Junjie
AU - Jiang, Gening
AU - Fei, Ke
AU - Park, Jae Yong
AU - Kim, Yeul Hong
AU - Sung, Jae Sook
AU - Park, Kyong Hwa
AU - Kim, Young Tae
AU - Jung, Yoo Jin
AU - Kang, Chang Hyun
AU - Park, In Kyu
AU - Kim, Hee Nam
AU - Jeon, Hyo Sung
AU - Choi, Jin Eun
AU - Choi, Yi Young
AU - Kim, Jin Hee
AU - Oh, In Jae
AU - Kim, Young Chul
AU - Sung, Sook Whan
AU - Kim, Jun Suk
AU - Yoon, Ho Il
AU - Kweon, Sun Seog
AU - Shin, Min Ho
AU - Seow, Adeline
AU - Chen, Ying
AU - Lim, Wei Yen
AU - Liu, Jianjun
AU - Wong, Maria Pik
AU - Lee, Victor Ho Fun
AU - Bassig, Bryan A.
AU - Tucker, Margaret
AU - Berndt, Sonja I.
AU - Chow, Wong Ho
AU - Ji, Bu Tian
AU - Wang, Junwen
AU - Xu, Jun
AU - Sihoe, Alan Dart Loon
AU - Ho, James C.M.
AU - Chan, John K.C.
AU - Wang, Jiu Cun
AU - Lu, Daru
AU - Zhao, Xueying
AU - Zhao, Zhenhong
AU - Wu, Junjie
AU - Chen, Hongyan
AU - Jin, Li
AU - Wei, Fusheng
AU - Wu, Guoping
AU - An, She Juan
AU - Zhang, Xu Chao
AU - Su, Jian
AU - Wu, Yi Long
AU - Gao, Yu Tang
AU - Xiang, Yong Bing
AU - He, Xingzhou
AU - Li, Jihua
AU - Zheng, Wei
AU - Shu, Xiao Ou
AU - Cai, Qiuyin
AU - Klein, Robert
AU - Pao, William
AU - Lawrence, Charles
AU - Hosgood, H. Dean
AU - Hsiao, Chin Fu
AU - Chien, Li Hsin
AU - Chen, Ying Hsiang
AU - Chen, Chung Hsing
AU - Wang, Wen Chang
AU - Chen, Chih Yi
AU - Wang, Chih Liang
AU - Yu, Chong Jen
AU - Chen, Hui Ling
AU - Su, Yu Chun
AU - Tsai, Fang Yu
AU - Chen, Yi Song
AU - Li, Yao Jen
AU - Yang, Tsung Ying
AU - Lin, Chien Chung
AU - Yang, Pan Chyr
AU - Wu, Tangchun
AU - Lin, Dongxin
AU - Zhou, Baosen
AU - Yu, Jinming
AU - Shen, Hongbing
AU - Kubo, Michiaki
AU - Chanock, Stephen J.
AU - Rothman, Nathaniel
AU - Lan, Qing
N1 - Funding Information: The Japan Lung Cancer Study (JLCS) was supported by a Grantin-Aid from the Japan Agency for Medical Research and Development (AMED) for the Health and Labor Sciences Research Expenses for Commission (the Practical Research for Innovative Cancer Control: H26-practical-general-094) and the Management Expenses Grants from the Government to the National Cancer Center (26-A-1) for Biobank. BioBank Japan was supported by the Ministry of Education, Culture, Sports, Sciences and Technology of the Japanese government. The Japan Public Health Center based prospective Study (the JPHC Study) was supported by National Cancer Center Research and Development Fund (23-A-31[toku] and 26-A-2) (since 2011) and a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan (from1989 to 2010). The Taiwan GELAC Study (Genetic Epidemiological Study for Lung AdenoCarcinoma) was supported by grants from the National Research Program on Genomic Medicine in Taiwan (DOH99-TD-G-111-028), the National Research Program for Biopharmaceuticals in Taiwan (MOHW 103-TDUPB-211-144003, MOST 103-2325-B-400-023) and Bioinformatics Core Facility for Translational Medicine and Biotechnology Development (MOST 104-2319-B-400-002). This work was also supported by the Jinan Science Research Project Foundation (201102051), Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) in China (IRT_14R40), the National Key Scientific and Technological Project (2011ZX09307-001-04), the National Natural Science Foundation of China (No. 81272293), the State Key Program of National Natural Science of China (81230067), the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. NRF-2014R1A2A2A05003665), Agency for Science, Technology and Research (A*STAR), Singapore and the US National Institute of Health Grant (1U19CA148127-01). The overall GWAS project was supported by the intramural program of the US National Institutes of Health/National Cancer Institute.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10-13), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10-10) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10-9). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.
AB - Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10-13), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10-10) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10-9). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.
UR - http://www.scopus.com/inward/record.url?scp=84960858474&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960858474&partnerID=8YFLogxK
U2 - 10.1093/hmg/ddv494
DO - 10.1093/hmg/ddv494
M3 - Article
C2 - 26732429
AN - SCOPUS:84960858474
VL - 25
SP - 620
EP - 629
JO - Human Molecular Genetics
JF - Human Molecular Genetics
SN - 0964-6906
IS - 3
ER -