Meta-analysis of predictive clinicopathologic factors for lymph node metastasis in patients with early colorectal carcinoma

The Korean ESD Study Group

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The objective of this study was to conduct a meta-analysis to determine risk factors that may facilitate patient selection for radical resections or additional resections after a polypectomy. Eligible articles were identified by searches of PUBMED, Cochrane Library and Korean Medical Database using the terms (early colorectal carcinoma [ECC], lymph node metastasis [LNM], colectomy, endoscopic resection). Thirteen cohort studies of 7,066 ECC patients who only underwent radical surgery have been analysed. There was a significant risk of LNM when they had submucosal invasion (≥ SM2 or ≥ 1,000 μm) (odds Ratio [OR], 3.00; 95% confidence interval [CI], 1.36-6.62, P = 0.007). Moreover, it has been found that vascular invasion (OR, 2.70; 95% CI, 1.95-3.74; P < 0.001), lymphatic invasion (OR, 6.91; 95% CI, 5.40-8.85; P < 0.001), poorly differentiated carcinomas (OR, 8.27; 95% CI, 4.67-14.66; P < 0.001) and tumor budding (OR, 4.59; 95% CI, 3.44-6.13; P < 0.001) were significantly associated with LNM. Furthermore, another analysis was carried out on eight cohort studies of 310 patients who underwent additional surgeries after an endoscopic resection. The major factors identified in these studies include lymphovascular invasion on polypectomy specimens (OR, 5.47; 95% CI, 2.46-12.17; P < 0.001) and poorly or moderately differentiated carcinomas (OR, 4.07; 95% CI, 1.08-15.33; P = 0.04). For ECC patients with ≥ SM2 or ≥ 1,000 μm submucosal invasion, vascular invasion, lymphatic invasion, poorly differentiated carcinomas or tumor budding, it is deemed that a more extensive resection accompanied by a lymph node dissection is necessary. Even if the lesion is completely removed by an endoscopic resection, an additional surgical resection should be considered in patients with poorly or moderately differentiated carcinomas or lymphovascular invasion.

Original languageEnglish
Pages (from-to)398-406
Number of pages9
JournalJournal of Korean Medical Science
Volume30
Issue number4
DOIs
Publication statusPublished - 2015 Jan 1

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Meta-Analysis
Colorectal Neoplasms
Lymph Nodes
Odds Ratio
Confidence Intervals
Neoplasm Metastasis
Carcinoma
Blood Vessels
Cohort Studies
Medical Libraries
Colectomy
Lymph Node Excision
Patient Selection
Neoplasms
Databases

Keywords

  • Colectomy
  • Colorectal neoplasms
  • Endoscopy
  • Lymph nodes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Meta-analysis of predictive clinicopathologic factors for lymph node metastasis in patients with early colorectal carcinoma. / The Korean ESD Study Group.

In: Journal of Korean Medical Science, Vol. 30, No. 4, 01.01.2015, p. 398-406.

Research output: Contribution to journalArticle

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abstract = "The objective of this study was to conduct a meta-analysis to determine risk factors that may facilitate patient selection for radical resections or additional resections after a polypectomy. Eligible articles were identified by searches of PUBMED, Cochrane Library and Korean Medical Database using the terms (early colorectal carcinoma [ECC], lymph node metastasis [LNM], colectomy, endoscopic resection). Thirteen cohort studies of 7,066 ECC patients who only underwent radical surgery have been analysed. There was a significant risk of LNM when they had submucosal invasion (≥ SM2 or ≥ 1,000 μm) (odds Ratio [OR], 3.00; 95{\%} confidence interval [CI], 1.36-6.62, P = 0.007). Moreover, it has been found that vascular invasion (OR, 2.70; 95{\%} CI, 1.95-3.74; P < 0.001), lymphatic invasion (OR, 6.91; 95{\%} CI, 5.40-8.85; P < 0.001), poorly differentiated carcinomas (OR, 8.27; 95{\%} CI, 4.67-14.66; P < 0.001) and tumor budding (OR, 4.59; 95{\%} CI, 3.44-6.13; P < 0.001) were significantly associated with LNM. Furthermore, another analysis was carried out on eight cohort studies of 310 patients who underwent additional surgeries after an endoscopic resection. The major factors identified in these studies include lymphovascular invasion on polypectomy specimens (OR, 5.47; 95{\%} CI, 2.46-12.17; P < 0.001) and poorly or moderately differentiated carcinomas (OR, 4.07; 95{\%} CI, 1.08-15.33; P = 0.04). For ECC patients with ≥ SM2 or ≥ 1,000 μm submucosal invasion, vascular invasion, lymphatic invasion, poorly differentiated carcinomas or tumor budding, it is deemed that a more extensive resection accompanied by a lymph node dissection is necessary. Even if the lesion is completely removed by an endoscopic resection, an additional surgical resection should be considered in patients with poorly or moderately differentiated carcinomas or lymphovascular invasion.",
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