Meta-analysis of the family-based association between the PTPN22 C1858T polymorphism and Type 1 diabetes

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to type 1 diabetes (T1D). We conducted a meta-analysis of the transmission disequilibrium test (TDT) examining preferential transmission of the T allele of the PTPN22 C1858T polymorphism to children with T1D. A total of 11 studies were included in this meta-analysis, which contained 3,946 families and 2,024 transmissions of the PTPN22 T allele in 11 European populations. The frequencies of the transmitted and non-transmitted T allele were 1,250 (61.8%) and 774 (38.2%), respectively. The T allele was transmitted to T1D offspring more often than expected. Meta-analysis showed a significant association between the PTPN22 T allele and T1D (OR 1.611, 95% CI 1.421, 1.827, p<1×10-8) without between-study heterogeneity (I 2=32.5, p=0.138). Publication bias was observed in this meta-analysis (Egger's regression test, p-values=0.061), but the adjusted OR calculated using the trim and fill technique remained significant (OR 1.577, 95% CI 1.392, 1.785). This meta-analysis of TDT confirms that the PTPN22 C1858T polymorphism is associated with T1D susceptibility in Europeans.

Original languageEnglish
Pages (from-to)211-215
Number of pages5
JournalMolecular Biology Reports
Volume40
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

Protein Tyrosine Phosphatases
Type 1 Diabetes Mellitus
Meta-Analysis
Alleles
Publication Bias
Population

Keywords

  • Meta-analysis
  • Polymorphism
  • Protein tyrosine phosphatase nonreceptor 22
  • Type 1 diabetes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

@article{ea19361177454ae6b4d96910efc84fc2,
title = "Meta-analysis of the family-based association between the PTPN22 C1858T polymorphism and Type 1 diabetes",
abstract = "The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to type 1 diabetes (T1D). We conducted a meta-analysis of the transmission disequilibrium test (TDT) examining preferential transmission of the T allele of the PTPN22 C1858T polymorphism to children with T1D. A total of 11 studies were included in this meta-analysis, which contained 3,946 families and 2,024 transmissions of the PTPN22 T allele in 11 European populations. The frequencies of the transmitted and non-transmitted T allele were 1,250 (61.8{\%}) and 774 (38.2{\%}), respectively. The T allele was transmitted to T1D offspring more often than expected. Meta-analysis showed a significant association between the PTPN22 T allele and T1D (OR 1.611, 95{\%} CI 1.421, 1.827, p<1×10-8) without between-study heterogeneity (I 2=32.5, p=0.138). Publication bias was observed in this meta-analysis (Egger's regression test, p-values=0.061), but the adjusted OR calculated using the trim and fill technique remained significant (OR 1.577, 95{\%} CI 1.392, 1.785). This meta-analysis of TDT confirms that the PTPN22 C1858T polymorphism is associated with T1D susceptibility in Europeans.",
keywords = "Meta-analysis, Polymorphism, Protein tyrosine phosphatase nonreceptor 22, Type 1 diabetes",
author = "Lee, {Young Ho} and Song, {Gwan Gyu}",
year = "2013",
month = "1",
day = "1",
doi = "10.1007/s11033-012-2051-8",
language = "English",
volume = "40",
pages = "211--215",
journal = "Molecular Biology Reports",
issn = "0301-4851",
publisher = "Springer Netherlands",
number = "1",

}

TY - JOUR

T1 - Meta-analysis of the family-based association between the PTPN22 C1858T polymorphism and Type 1 diabetes

AU - Lee, Young Ho

AU - Song, Gwan Gyu

PY - 2013/1/1

Y1 - 2013/1/1

N2 - The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to type 1 diabetes (T1D). We conducted a meta-analysis of the transmission disequilibrium test (TDT) examining preferential transmission of the T allele of the PTPN22 C1858T polymorphism to children with T1D. A total of 11 studies were included in this meta-analysis, which contained 3,946 families and 2,024 transmissions of the PTPN22 T allele in 11 European populations. The frequencies of the transmitted and non-transmitted T allele were 1,250 (61.8%) and 774 (38.2%), respectively. The T allele was transmitted to T1D offspring more often than expected. Meta-analysis showed a significant association between the PTPN22 T allele and T1D (OR 1.611, 95% CI 1.421, 1.827, p<1×10-8) without between-study heterogeneity (I 2=32.5, p=0.138). Publication bias was observed in this meta-analysis (Egger's regression test, p-values=0.061), but the adjusted OR calculated using the trim and fill technique remained significant (OR 1.577, 95% CI 1.392, 1.785). This meta-analysis of TDT confirms that the PTPN22 C1858T polymorphism is associated with T1D susceptibility in Europeans.

AB - The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to type 1 diabetes (T1D). We conducted a meta-analysis of the transmission disequilibrium test (TDT) examining preferential transmission of the T allele of the PTPN22 C1858T polymorphism to children with T1D. A total of 11 studies were included in this meta-analysis, which contained 3,946 families and 2,024 transmissions of the PTPN22 T allele in 11 European populations. The frequencies of the transmitted and non-transmitted T allele were 1,250 (61.8%) and 774 (38.2%), respectively. The T allele was transmitted to T1D offspring more often than expected. Meta-analysis showed a significant association between the PTPN22 T allele and T1D (OR 1.611, 95% CI 1.421, 1.827, p<1×10-8) without between-study heterogeneity (I 2=32.5, p=0.138). Publication bias was observed in this meta-analysis (Egger's regression test, p-values=0.061), but the adjusted OR calculated using the trim and fill technique remained significant (OR 1.577, 95% CI 1.392, 1.785). This meta-analysis of TDT confirms that the PTPN22 C1858T polymorphism is associated with T1D susceptibility in Europeans.

KW - Meta-analysis

KW - Polymorphism

KW - Protein tyrosine phosphatase nonreceptor 22

KW - Type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=84871309395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871309395&partnerID=8YFLogxK

U2 - 10.1007/s11033-012-2051-8

DO - 10.1007/s11033-012-2051-8

M3 - Article

VL - 40

SP - 211

EP - 215

JO - Molecular Biology Reports

JF - Molecular Biology Reports

SN - 0301-4851

IS - 1

ER -