Metaanalyse von Genpolymorphismen beim programmierten Zelltod 1: Assoziationen mit der Suzeptibiliät für rheumatoide Arthritis, ankylosierende Spondylitis und Typ-1-Diabetes

Young Ho Lee; S. C. Bae; J. H. Kim; Gwan Gyu Song

doi:10.1007/s00393-014-1415-y

Metaanalyse von Genpolymorphismen beim programmierten Zelltod 1: Assoziationen mit der Suzeptibiliät für rheumatoide Arthritis, ankylosierende Spondylitis und Typ-1-Diabetes

Translated title of the contribution: Meta-analysis of genetic polymorphisms in programmed cell death 1: Associations with rheumatoid arthritis, ankylosing spondylitis, and type 1 diabetes susceptibility

Young Ho Lee, S. C. Bae, J. H. Kim, Gwan Gyu Song

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Objective: The aim of this study was to determine whether genetic polymorphisms in programmed cell death 1 (PDCD1 or PD1) are associated with susceptibility to rheumatoid arthritis (RA), ankylosing spondylitis (AS), and type 1 diabetes (T1D).

Methods: We conducted a meta-analysis to investigate the association between PDCD1 polymorphisms and RA, AS, and T1D in the overall population and in specific ethnic populations.

Results: Sixteen studies, comprising 13,210 patients and 17,073 controls, were conducted for the meta-analysis including 4 studies on RA, 4 on AS, and 8 on T1D. The meta-analysis showed an association between RA and the 2 alleles of the PD1.3 polymorphism in the overall population [odds ratio (OR) 1.183, 95 % confidence interval (95 % CI) 1.005–1.392, p = 0.043]. However, meta-analysis showed no association between RA and the 2 alleles of the PD1.1 and PD1.5 polymorphisms in the overall population. Meta-analysis identified an association between AS and the 2 alleles of the PD1.5 and PD1.9 polymorphisms in the Asian population (OR 1.251, 95 % CI 1.019–1.535, p = 0.033; OR 1.975, 95 % CI 1.286–3.034, p = 0.002, respectively). The meta-analysis revealed a significant association between T1D and the 2 alleles of the PD1.3 polymorphism in the European population (OR 1.098, 95 % CI 1.029–1.171, p = 0.005). The meta-analysis showed an association between the PD1.5 polymorphism and T1D in Asians (OR 1.332, 95 % CI 1.067–1.663, p = 0.011) and between the PD1.9 polymorphism and T1D in the Asian population (OR 1.363, 95 % CI 1.107–1.679, p = 0.004).

Conclusion: The meta-analysis suggests an association between the PD1.3 polymorphism and RA in the overall population and an association between the PD1.5 and PD1.9 polymorphisms, and AS in the Asian population. Furthermore, the PD1.3, 5, and 9 polymorphisms were associated with T1D susceptibility in Europeans, or Asians.

Translated title of the contribution	Meta-analysis of genetic polymorphisms in programmed cell death 1: Associations with rheumatoid arthritis, ankylosing spondylitis, and type 1 diabetes susceptibility
Original language	German
Pages (from-to)	230-239
Number of pages	10
Journal	Zeitschrift fur Rheumatologie
Volume	74
Issue number	3
DOIs	https://doi.org/10.1007/s00393-014-1415-y
Publication status	Published - 2015 Apr 1

Keywords

Apoptosis
Autoimmune diseases
Gene frequency
Inflammation
Peripheral tolerance

ASJC Scopus subject areas

Rheumatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00393-014-1415-y

Cite this

@article{7029d4934d16407bb08ad63b10408901,

title = "Metaanalyse von Genpolymorphismen beim programmierten Zelltod 1: Assoziationen mit der Suzeptibili{\"a}t f{\"u}r rheumatoide Arthritis, ankylosierende Spondylitis und Typ-1-Diabetes",

abstract = "Objective: The aim of this study was to determine whether genetic polymorphisms in programmed cell death 1 (PDCD1 or PD1) are associated with susceptibility to rheumatoid arthritis (RA), ankylosing spondylitis (AS), and type 1 diabetes (T1D).Methods: We conducted a meta-analysis to investigate the association between PDCD1 polymorphisms and RA, AS, and T1D in the overall population and in specific ethnic populations.Results: Sixteen studies, comprising 13,210 patients and 17,073 controls, were conducted for the meta-analysis including 4 studies on RA, 4 on AS, and 8 on T1D. The meta-analysis showed an association between RA and the 2 alleles of the PD1.3 polymorphism in the overall population [odds ratio (OR) 1.183, 95 % confidence interval (95 % CI) 1.005–1.392, p = 0.043]. However, meta-analysis showed no association between RA and the 2 alleles of the PD1.1 and PD1.5 polymorphisms in the overall population. Meta-analysis identified an association between AS and the 2 alleles of the PD1.5 and PD1.9 polymorphisms in the Asian population (OR 1.251, 95 % CI 1.019–1.535, p = 0.033; OR 1.975, 95 % CI 1.286–3.034, p = 0.002, respectively). The meta-analysis revealed a significant association between T1D and the 2 alleles of the PD1.3 polymorphism in the European population (OR 1.098, 95 % CI 1.029–1.171, p = 0.005). The meta-analysis showed an association between the PD1.5 polymorphism and T1D in Asians (OR 1.332, 95 % CI 1.067–1.663, p = 0.011) and between the PD1.9 polymorphism and T1D in the Asian population (OR 1.363, 95 % CI 1.107–1.679, p = 0.004).Conclusion: The meta-analysis suggests an association between the PD1.3 polymorphism and RA in the overall population and an association between the PD1.5 and PD1.9 polymorphisms, and AS in the Asian population. Furthermore, the PD1.3, 5, and 9 polymorphisms were associated with T1D susceptibility in Europeans, or Asians.",

keywords = "Apoptosis, Autoimmune diseases, Gene frequency, Inflammation, Peripheral tolerance",

author = "Lee, {Young Ho} and Bae, {S. C.} and Kim, {J. H.} and Song, {Gwan Gyu}",

year = "2015",

month = apr,

day = "1",

doi = "10.1007/s00393-014-1415-y",

language = "German",

volume = "74",

pages = "230--239",

journal = "Zeitschrift fur Rheumatologie",

issn = "0340-1855",

publisher = "D. Steinkopff-Verlag",

number = "3",

}

TY - JOUR

T1 - Metaanalyse von Genpolymorphismen beim programmierten Zelltod 1

T2 - Assoziationen mit der Suzeptibiliät für rheumatoide Arthritis, ankylosierende Spondylitis und Typ-1-Diabetes

AU - Lee, Young Ho

AU - Bae, S. C.

AU - Kim, J. H.

AU - Song, Gwan Gyu

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Objective: The aim of this study was to determine whether genetic polymorphisms in programmed cell death 1 (PDCD1 or PD1) are associated with susceptibility to rheumatoid arthritis (RA), ankylosing spondylitis (AS), and type 1 diabetes (T1D).Methods: We conducted a meta-analysis to investigate the association between PDCD1 polymorphisms and RA, AS, and T1D in the overall population and in specific ethnic populations.Results: Sixteen studies, comprising 13,210 patients and 17,073 controls, were conducted for the meta-analysis including 4 studies on RA, 4 on AS, and 8 on T1D. The meta-analysis showed an association between RA and the 2 alleles of the PD1.3 polymorphism in the overall population [odds ratio (OR) 1.183, 95 % confidence interval (95 % CI) 1.005–1.392, p = 0.043]. However, meta-analysis showed no association between RA and the 2 alleles of the PD1.1 and PD1.5 polymorphisms in the overall population. Meta-analysis identified an association between AS and the 2 alleles of the PD1.5 and PD1.9 polymorphisms in the Asian population (OR 1.251, 95 % CI 1.019–1.535, p = 0.033; OR 1.975, 95 % CI 1.286–3.034, p = 0.002, respectively). The meta-analysis revealed a significant association between T1D and the 2 alleles of the PD1.3 polymorphism in the European population (OR 1.098, 95 % CI 1.029–1.171, p = 0.005). The meta-analysis showed an association between the PD1.5 polymorphism and T1D in Asians (OR 1.332, 95 % CI 1.067–1.663, p = 0.011) and between the PD1.9 polymorphism and T1D in the Asian population (OR 1.363, 95 % CI 1.107–1.679, p = 0.004).Conclusion: The meta-analysis suggests an association between the PD1.3 polymorphism and RA in the overall population and an association between the PD1.5 and PD1.9 polymorphisms, and AS in the Asian population. Furthermore, the PD1.3, 5, and 9 polymorphisms were associated with T1D susceptibility in Europeans, or Asians.

AB - Objective: The aim of this study was to determine whether genetic polymorphisms in programmed cell death 1 (PDCD1 or PD1) are associated with susceptibility to rheumatoid arthritis (RA), ankylosing spondylitis (AS), and type 1 diabetes (T1D).Methods: We conducted a meta-analysis to investigate the association between PDCD1 polymorphisms and RA, AS, and T1D in the overall population and in specific ethnic populations.Results: Sixteen studies, comprising 13,210 patients and 17,073 controls, were conducted for the meta-analysis including 4 studies on RA, 4 on AS, and 8 on T1D. The meta-analysis showed an association between RA and the 2 alleles of the PD1.3 polymorphism in the overall population [odds ratio (OR) 1.183, 95 % confidence interval (95 % CI) 1.005–1.392, p = 0.043]. However, meta-analysis showed no association between RA and the 2 alleles of the PD1.1 and PD1.5 polymorphisms in the overall population. Meta-analysis identified an association between AS and the 2 alleles of the PD1.5 and PD1.9 polymorphisms in the Asian population (OR 1.251, 95 % CI 1.019–1.535, p = 0.033; OR 1.975, 95 % CI 1.286–3.034, p = 0.002, respectively). The meta-analysis revealed a significant association between T1D and the 2 alleles of the PD1.3 polymorphism in the European population (OR 1.098, 95 % CI 1.029–1.171, p = 0.005). The meta-analysis showed an association between the PD1.5 polymorphism and T1D in Asians (OR 1.332, 95 % CI 1.067–1.663, p = 0.011) and between the PD1.9 polymorphism and T1D in the Asian population (OR 1.363, 95 % CI 1.107–1.679, p = 0.004).Conclusion: The meta-analysis suggests an association between the PD1.3 polymorphism and RA in the overall population and an association between the PD1.5 and PD1.9 polymorphisms, and AS in the Asian population. Furthermore, the PD1.3, 5, and 9 polymorphisms were associated with T1D susceptibility in Europeans, or Asians.

KW - Apoptosis

KW - Autoimmune diseases

KW - Gene frequency

KW - Inflammation

KW - Peripheral tolerance

UR - http://www.scopus.com/inward/record.url?scp=84939892080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939892080&partnerID=8YFLogxK

U2 - 10.1007/s00393-014-1415-y

DO - 10.1007/s00393-014-1415-y

M3 - Article

C2 - 24942602

AN - SCOPUS:84939892080

SN - 0340-1855

VL - 74

SP - 230

EP - 239

JO - Zeitschrift fur Rheumatologie

JF - Zeitschrift fur Rheumatologie

IS - 3

ER -