Metaanalyse von SLC22A4- und RUNX1-Polymorphismen: Assoziationen mit der Suszeptibilität für rheumatoide Arthritis

Y. H. Lee; S. C. Bae; J. H. Kim; Y. H. Seo; S. J. Choi; J. D. Ji; G. G. Song

doi:10.1007/s00393-014-1447-3

Metaanalyse von SLC22A4- und RUNX1-Polymorphismen: Assoziationen mit der Suszeptibilität für rheumatoide Arthritis

Translated title of the contribution: Meta-analysis of SLC22A4 and RUNX1 polymorphisms: Associations with rheumatoid arthritis susceptibility

Y. H. Lee, S. C. Bae, J. H. Kim, Y. H. Seo, S. J. Choi, J. D. Ji, G. G. Song

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Objective: The aim in this study was to determine whether solute carrier family 22, member 4 (SLC22A4), and runt-related transcription factor 1 (RUNX1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) in populations of different ethnicities.

Methods: We conducted a literature search using the MEDLINE and EMBASE, and performed a meta-analysis using a fixed or random effects model.

Results: A total of 26 comparative studies from 14 articles met the study inclusion criteria. Studies on the SLC22A4 polymorphism involved 12,458 RA patients and 9283 controls, and studies on the RUNX1 polymorphism involved 3958 RA patients and 3773 controls. The meta-analysis showed no association between the 22 + 21 genotype of the SLC22A4 F1 and RA in overall group [odds ratio (OR) 1.074, 95 % confidence interval (CI) 0.952–1.212, p = 0.245]. After stratification by ethnicity, the meta-analysis indicated that the 22 + 21 genotype of the SLC22A4 F1 was associated significantly with RA in the East Asian population, but not in the European population (OR 1.124, 95 % CI 1.018–1.240, p = 0.021; OR 0.981, 95 % CI 0.773–1.243, p = 0.871).

Conclusion: This meta-analysis demonstrates that the SLC22A4 F1 polymorphism is associated with susceptibility to RA in East Asians, but not in Europeans.

Translated title of the contribution	Meta-analysis of SLC22A4 and RUNX1 polymorphisms: Associations with rheumatoid arthritis susceptibility
Original language	German
Pages (from-to)	351-358
Number of pages	8
Journal	Zeitschrift fur Rheumatologie
Volume	74
Issue number	4
DOIs	https://doi.org/10.1007/s00393-014-1447-3
Publication status	Published - 2015 May 1

Keywords

Autoimmune diseases
Ethnicity
Gene frequency
Inflammation
Literature review

ASJC Scopus subject areas

Rheumatology

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10.1007/s00393-014-1447-3

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@article{636abfbd40d04173b21e81025a23cbb0,

title = "Metaanalyse von SLC22A4- und RUNX1-Polymorphismen: Assoziationen mit der Suszeptibilit{\"a}t f{\"u}r rheumatoide Arthritis",

abstract = "Objective: The aim in this study was to determine whether solute carrier family 22, member 4 (SLC22A4), and runt-related transcription factor 1 (RUNX1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) in populations of different ethnicities.Methods: We conducted a literature search using the MEDLINE and EMBASE, and performed a meta-analysis using a fixed or random effects model.Results: A total of 26 comparative studies from 14 articles met the study inclusion criteria. Studies on the SLC22A4 polymorphism involved 12,458 RA patients and 9283 controls, and studies on the RUNX1 polymorphism involved 3958 RA patients and 3773 controls. The meta-analysis showed no association between the 22 + 21 genotype of the SLC22A4 F1 and RA in overall group [odds ratio (OR) 1.074, 95 % confidence interval (CI) 0.952–1.212, p = 0.245]. After stratification by ethnicity, the meta-analysis indicated that the 22 + 21 genotype of the SLC22A4 F1 was associated significantly with RA in the East Asian population, but not in the European population (OR 1.124, 95 % CI 1.018–1.240, p = 0.021; OR 0.981, 95 % CI 0.773–1.243, p = 0.871).Conclusion: This meta-analysis demonstrates that the SLC22A4 F1 polymorphism is associated with susceptibility to RA in East Asians, but not in Europeans.",

keywords = "Autoimmune diseases, Ethnicity, Gene frequency, Inflammation, Literature review",

author = "Lee, {Y. H.} and Bae, {S. C.} and Kim, {J. H.} and Seo, {Y. H.} and Choi, {S. J.} and Ji, {J. D.} and Song, {G. G.}",

year = "2015",

month = may,

day = "1",

doi = "10.1007/s00393-014-1447-3",

language = "German",

volume = "74",

pages = "351--358",

journal = "Zeitschrift fur Rheumatologie",

issn = "0340-1855",

publisher = "D. Steinkopff-Verlag",

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}

TY - JOUR

T1 - Metaanalyse von SLC22A4- und RUNX1-Polymorphismen

T2 - Assoziationen mit der Suszeptibilität für rheumatoide Arthritis

AU - Lee, Y. H.

AU - Bae, S. C.

AU - Kim, J. H.

AU - Seo, Y. H.

AU - Choi, S. J.

AU - Ji, J. D.

AU - Song, G. G.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Objective: The aim in this study was to determine whether solute carrier family 22, member 4 (SLC22A4), and runt-related transcription factor 1 (RUNX1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) in populations of different ethnicities.Methods: We conducted a literature search using the MEDLINE and EMBASE, and performed a meta-analysis using a fixed or random effects model.Results: A total of 26 comparative studies from 14 articles met the study inclusion criteria. Studies on the SLC22A4 polymorphism involved 12,458 RA patients and 9283 controls, and studies on the RUNX1 polymorphism involved 3958 RA patients and 3773 controls. The meta-analysis showed no association between the 22 + 21 genotype of the SLC22A4 F1 and RA in overall group [odds ratio (OR) 1.074, 95 % confidence interval (CI) 0.952–1.212, p = 0.245]. After stratification by ethnicity, the meta-analysis indicated that the 22 + 21 genotype of the SLC22A4 F1 was associated significantly with RA in the East Asian population, but not in the European population (OR 1.124, 95 % CI 1.018–1.240, p = 0.021; OR 0.981, 95 % CI 0.773–1.243, p = 0.871).Conclusion: This meta-analysis demonstrates that the SLC22A4 F1 polymorphism is associated with susceptibility to RA in East Asians, but not in Europeans.

AB - Objective: The aim in this study was to determine whether solute carrier family 22, member 4 (SLC22A4), and runt-related transcription factor 1 (RUNX1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) in populations of different ethnicities.Methods: We conducted a literature search using the MEDLINE and EMBASE, and performed a meta-analysis using a fixed or random effects model.Results: A total of 26 comparative studies from 14 articles met the study inclusion criteria. Studies on the SLC22A4 polymorphism involved 12,458 RA patients and 9283 controls, and studies on the RUNX1 polymorphism involved 3958 RA patients and 3773 controls. The meta-analysis showed no association between the 22 + 21 genotype of the SLC22A4 F1 and RA in overall group [odds ratio (OR) 1.074, 95 % confidence interval (CI) 0.952–1.212, p = 0.245]. After stratification by ethnicity, the meta-analysis indicated that the 22 + 21 genotype of the SLC22A4 F1 was associated significantly with RA in the East Asian population, but not in the European population (OR 1.124, 95 % CI 1.018–1.240, p = 0.021; OR 0.981, 95 % CI 0.773–1.243, p = 0.871).Conclusion: This meta-analysis demonstrates that the SLC22A4 F1 polymorphism is associated with susceptibility to RA in East Asians, but not in Europeans.

KW - Autoimmune diseases

KW - Ethnicity

KW - Gene frequency

KW - Inflammation

KW - Literature review

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U2 - 10.1007/s00393-014-1447-3

DO - 10.1007/s00393-014-1447-3

M3 - Article

C2 - 24972750

AN - SCOPUS:84939888533

SN - 0340-1855

VL - 74

SP - 351

EP - 358

JO - Zeitschrift fur Rheumatologie

JF - Zeitschrift fur Rheumatologie

IS - 4

ER -

Metaanalyse von SLC22A4- und RUNX1-Polymorphismen: Assoziationen mit der Suszeptibilität für rheumatoide Arthritis

Abstract

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