Metabolic complications among Korean patients with HIV infection: The Korea HIV/AIDS cohort study

Korea HIV/AIDS Cohort Study

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Currently, metabolic complications are the most common problem among human immunodeficiency virus (HIV)-infected patients, with a high incidence. However, there have been very few studies regarding metabolic abnormalities published in Asia, especially in Korea. This cross-sectional study was performed to investigate the prevalence of and risk factors for metabolic abnormalities in 1,096 HIV-infected patients of the Korea HIV/AIDS cohort study enrolled from 19 hospitals between 2006 and 2013. Data at entry to cohort were analyzed. As a result, the median age of the 1,096 enrolled subjects was 46 years, and most patients were men (92.8%). The metabolic profiles of the patients were as follows: median weight was 63.8 kg, median body mass index (BMI) was 22.2 kg/m2, and 16.4% of the patients had a BMI over 25 kg/m2. A total of 5.5% of the patients had abdominal obesity (waist/hip ratio ≥ 1 in men, ≥ 0.85 in women). Increased levels of fasting glucose, total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides were present in 10.4%, 6.0%, 5.5%, and 32.1% of the patients. Decreased high-density lipoprotein (HDL) cholesterol levels were observed in 44.2% of the patients. High systolic blood pressure was present in 14.3% of the patients. In multivariate analysis, high BMI and the use of protease inhibitors (PIs) were risk factors for dyslipidemia in HIVinfected patients. In conclusion, proper diagnosis and management should be offered for the prevalent metabolic complications of Korean HIV-infected patients. Further studies on risk factors for metabolic complications are needed.

Original languageEnglish
Pages (from-to)1268-1274
Number of pages7
JournalJournal of Korean Medical Science
Volume32
Issue number8
DOIs
Publication statusPublished - 2017 Aug 1

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Virus Diseases
Korea
Acquired Immunodeficiency Syndrome
Cohort Studies
HIV
Body Mass Index
Waist-Hip Ratio
Metabolome
Abdominal Obesity
Dyslipidemias
Protease Inhibitors
LDL Cholesterol
HDL Cholesterol
HIV-1
Fasting
Multivariate Analysis
Cross-Sectional Studies
Cholesterol
Blood Pressure
Hypertension

Keywords

  • Dyslipidemia
  • HIV infection
  • Metabolic complication
  • Protease inhibitor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Metabolic complications among Korean patients with HIV infection : The Korea HIV/AIDS cohort study. / Korea HIV/AIDS Cohort Study.

In: Journal of Korean Medical Science, Vol. 32, No. 8, 01.08.2017, p. 1268-1274.

Research output: Contribution to journalArticle

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abstract = "Currently, metabolic complications are the most common problem among human immunodeficiency virus (HIV)-infected patients, with a high incidence. However, there have been very few studies regarding metabolic abnormalities published in Asia, especially in Korea. This cross-sectional study was performed to investigate the prevalence of and risk factors for metabolic abnormalities in 1,096 HIV-infected patients of the Korea HIV/AIDS cohort study enrolled from 19 hospitals between 2006 and 2013. Data at entry to cohort were analyzed. As a result, the median age of the 1,096 enrolled subjects was 46 years, and most patients were men (92.8{\%}). The metabolic profiles of the patients were as follows: median weight was 63.8 kg, median body mass index (BMI) was 22.2 kg/m2, and 16.4{\%} of the patients had a BMI over 25 kg/m2. A total of 5.5{\%} of the patients had abdominal obesity (waist/hip ratio ≥ 1 in men, ≥ 0.85 in women). Increased levels of fasting glucose, total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides were present in 10.4{\%}, 6.0{\%}, 5.5{\%}, and 32.1{\%} of the patients. Decreased high-density lipoprotein (HDL) cholesterol levels were observed in 44.2{\%} of the patients. High systolic blood pressure was present in 14.3{\%} of the patients. In multivariate analysis, high BMI and the use of protease inhibitors (PIs) were risk factors for dyslipidemia in HIVinfected patients. In conclusion, proper diagnosis and management should be offered for the prevalent metabolic complications of Korean HIV-infected patients. Further studies on risk factors for metabolic complications are needed.",
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AU - Min, Ja Kim

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KW - Metabolic complication

KW - Protease inhibitor

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