Metabolic regulation of ferroptosis in cancer

Min Ji Kim; Greg Jiho Yun; Sung Eun Kim

doi:10.3390/biology10020083

Metabolic regulation of ferroptosis in cancer

Min Ji Kim, Greg Jiho Yun, Sung Eun Kim

Research output: Contribution to journal › Review article › peer-review

22 Citations (Scopus)

Abstract

Ferroptosis is a unique cell death mechanism that is executed by the excessive accumulation of lipid peroxidation in cells. The relevance of ferroptosis in multiple human diseases such as neurodegeneration, organ damage, and cancer is becoming increasingly evident. As ferroptosis is deeply intertwined with metabolic pathways such as iron, cyst(e)ine, glutathione, and lipid metab-olism, a better understanding of how ferroptosis is regulated by these pathways will enable the precise utilization or prevention of ferroptosis for therapeutic uses. In this review, we present an update of the mechanisms underlying diverse metabolic pathways that can regulate ferroptosis in cancer.

Original language	English
Article number	83
Pages (from-to)	1-21
Number of pages	21
Journal	Biology
Volume	10
Issue number	2
DOIs	https://doi.org/10.3390/biology10020083
Publication status	Published - 2021 Feb

Keywords

Cyst(e)ine metabolism
Ferroptosis
GPX4
Glutathione metabolism
Iron metabolism
Lipid peroxidation
Reactive oxygen species
SLC7A11

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/biology10020083

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title = "Metabolic regulation of ferroptosis in cancer",

abstract = "Ferroptosis is a unique cell death mechanism that is executed by the excessive accumulation of lipid peroxidation in cells. The relevance of ferroptosis in multiple human diseases such as neurodegeneration, organ damage, and cancer is becoming increasingly evident. As ferroptosis is deeply intertwined with metabolic pathways such as iron, cyst(e)ine, glutathione, and lipid metab-olism, a better understanding of how ferroptosis is regulated by these pathways will enable the precise utilization or prevention of ferroptosis for therapeutic uses. In this review, we present an update of the mechanisms underlying diverse metabolic pathways that can regulate ferroptosis in cancer.",

keywords = "Cyst(e)ine metabolism, Ferroptosis, GPX4, Glutathione metabolism, Iron metabolism, Lipid peroxidation, Reactive oxygen species, SLC7A11",

author = "Kim, {Min Ji} and Yun, {Greg Jiho} and Kim, {Sung Eun}",

note = "Funding Information: Funding: This work was supported by the Korean NRF Grant 2020R1C1C1013220 and Korea University Grant K1924741, K1926621, and K2007501 (S.E.K.). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = feb,

doi = "10.3390/biology10020083",

language = "English",

volume = "10",

pages = "1--21",

journal = "Biology",

issn = "2079-7737",

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TY - JOUR

T1 - Metabolic regulation of ferroptosis in cancer

AU - Kim, Min Ji

AU - Yun, Greg Jiho

AU - Kim, Sung Eun

N1 - Funding Information: Funding: This work was supported by the Korean NRF Grant 2020R1C1C1013220 and Korea University Grant K1924741, K1926621, and K2007501 (S.E.K.). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/2

Y1 - 2021/2

N2 - Ferroptosis is a unique cell death mechanism that is executed by the excessive accumulation of lipid peroxidation in cells. The relevance of ferroptosis in multiple human diseases such as neurodegeneration, organ damage, and cancer is becoming increasingly evident. As ferroptosis is deeply intertwined with metabolic pathways such as iron, cyst(e)ine, glutathione, and lipid metab-olism, a better understanding of how ferroptosis is regulated by these pathways will enable the precise utilization or prevention of ferroptosis for therapeutic uses. In this review, we present an update of the mechanisms underlying diverse metabolic pathways that can regulate ferroptosis in cancer.

AB - Ferroptosis is a unique cell death mechanism that is executed by the excessive accumulation of lipid peroxidation in cells. The relevance of ferroptosis in multiple human diseases such as neurodegeneration, organ damage, and cancer is becoming increasingly evident. As ferroptosis is deeply intertwined with metabolic pathways such as iron, cyst(e)ine, glutathione, and lipid metab-olism, a better understanding of how ferroptosis is regulated by these pathways will enable the precise utilization or prevention of ferroptosis for therapeutic uses. In this review, we present an update of the mechanisms underlying diverse metabolic pathways that can regulate ferroptosis in cancer.

KW - Cyst(e)ine metabolism

KW - Ferroptosis

KW - GPX4

KW - Glutathione metabolism

KW - Iron metabolism

KW - Lipid peroxidation

KW - Reactive oxygen species

KW - SLC7A11

UR - http://www.scopus.com/inward/record.url?scp=85099929675&partnerID=8YFLogxK

U2 - 10.3390/biology10020083

DO - 10.3390/biology10020083

M3 - Review article

AN - SCOPUS:85099929675

SN - 2079-7737

VL - 10

SP - 1

EP - 21

JO - Biology

JF - Biology

IS - 2

M1 - 83

ER -

Metabolic regulation of ferroptosis in cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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